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BOI2 Boi2p [ Saccharomyces cerevisiae S288C ]

Gene ID: 856850, updated on 18-Sep-2024

Summary

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Official Symbol
BOI2
Official Full Name
Boi2p
Primary source
SGD:S000000916
Locus tag
YER114C
See related
AllianceGenome:SGD:S000000916; FungiDB:YER114C; VEuPathDB:YER114C
Gene type
protein coding
RefSeq status
REVIEWED
Organism
Saccharomyces cerevisiae S288C (strain: S288C)
Lineage
Eukaryota; Fungi; Dikarya; Ascomycota; Saccharomycotina; Saccharomycetes; Saccharomycetales; Saccharomycetaceae; Saccharomyces
Also known as
BEB1
Summary
Enables phospholipid binding activity. Involved in several processes, including budding cell apical bud growth; septum digestion after cytokinesis; and vesicle fusion to plasma membrane. Located in cellular bud neck. Orthologous to human PLEKHA7 (pleckstrin homology domain containing A7). [provided by Alliance of Genome Resources, Apr 2022]
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Genomic context

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See BOI2 in Genome Data Viewer
Location:
chromosome: V
Exon count:
1
Sequence:
Chromosome: V; NC_001137.3 (390590..393712, complement)

Chromosome V - NC_001137.3Genomic Context describing neighboring genes Neighboring gene U6 snRNA complex subunit LSM4 Neighboring gene Tmn3p Neighboring gene Spr6p Neighboring gene SUMO-targeted ubiquitin ligase complex subunit SLX8

Genomic regions, transcripts, and products

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Genomic Sequence:
NC_001137.3

Go to nucleotide: Graphics FASTA GenBank

Bibliography

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Related articles in PubMed

  1. Probing the importance and potential roles of the binding of the PH-domain protein Boi1 to acidic phospholipids. Hallett MA, et al. BMC Cell Biol, 2002 Jun 27. PMID 12097146, Free PMC Article
  2. Multiple proteins and phosphorylations regulate Saccharomyces cerevisiae Cdc24p localization. Cole KC, et al. FEBS Lett, 2009 Oct 20. PMID 19782078
  3. Yeast src homology region 3 domain-binding proteins involved in bud formation. Matsui Y, et al. J Cell Biol, 1996 May. PMID 8666671, Free PMC Article
  4. The conserved histone deacetylase Rpd3 and the DNA binding regulator Ume6 repress BOI1's meiotic transcript isoform during vegetative growth in Saccharomyces cerevisiae. Liu Y, et al. Mol Microbiol, 2015 May. PMID 25708805
  5. Associations among PH and SH3 domain-containing proteins and Rho-type GTPases in Yeast. Bender L, et al. J Cell Biol, 1996 May. PMID 8666672, Free PMC Article

See all (65) citations in PubMed

GeneRIFs: Gene References Into Functions

What's a GeneRIF?
  1. Generation and characterization of conditional yeast mutants affecting each of the 2 essential functions of the scaffolding proteins Boi1/2 and Bem1.
    Title: Generation and characterization of conditional yeast mutants affecting each of the 2 essential functions of the scaffolding proteins Boi1/2 and Bem1.
  2. The Sur7/PalI family transmembrane protein Tos7 (Yol019w) plays a role in secretion in budding yeast.
    Title: The Sur7/PalI family transmembrane protein Tos7 (Yol019w) plays a role in secretion in budding yeast.
  3. Roles of the PH, coiled-coil and SAM domains of the yeast polarity protein Boi2 in polarity-site localization and function in polarized growth.
    Title: Roles of the PH, coiled-coil and SAM domains of the yeast polarity protein Boi2 in polarity-site localization and function in polarized growth.
Submit: New GeneRIF Correction

Interactions

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Products Interactant Other Gene Complex Source Pubs Description

General gene information

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Homology

Gene Ontology Provided by SGD

Function Evidence Code Pubs
enables phospholipid binding IDA
Inferred from Direct Assay
more info
 PubMed 
enables phospholipid binding ISS
Inferred from Sequence or Structural Similarity
more info
 PubMed 
Process Evidence Code Pubs
involved_in actin filament organization IGI
Inferred from Genetic Interaction
more info
 PubMed 
involved_in budding cell apical bud growth IGI
Inferred from Genetic Interaction
more info
 PubMed 
involved_in endosome organization IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in receptor recycling IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in retrograde transport, endosome to Golgi IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in septum digestion after cytokinesis IGI
Inferred from Genetic Interaction
more info
 PubMed 
involved_in vesicle fusion to plasma membrane IMP
Inferred from Mutant Phenotype
more info
 PubMed 
Component Evidence Code Pubs
is_active_in cellular bud IDA
Inferred from Direct Assay
more info
 PubMed 
located_in cellular bud IDA
Inferred from Direct Assay
more info
 PubMed 
located_in cellular bud neck IDA
Inferred from Direct Assay
more info
 PubMed 
located_in cytoplasm IEA
Inferred from Electronic Annotation
more info
  
located_in cytoskeleton IEA
Inferred from Electronic Annotation
more info
  
located_in cytosol IEA
Inferred from Electronic Annotation
more info
  
is_active_in early endosome IBA
Inferred from Biological aspect of Ancestor
more info
  
is_active_in recycling endosome IBA
Inferred from Biological aspect of Ancestor
more info
  
located_in site of polarized growth IDA
Inferred from Direct Assay
more info
 PubMed 
is_active_in trans-Golgi network IBA
Inferred from Biological aspect of Ancestor
more info
  

General protein information

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Preferred Names
Boi2p
NP_011039.1
  • Protein involved in polar growth; functionally redundant with Boi1p; required for fusion of secretory vesicles with plasma membrane at sites of polarized growth and for inhibition of membrane abscission until the end of cytokinesis; interacts with bud-emergence protein Bem1p; contains an SH3 (src homology 3) domain and a PH (pleckstrin homology) domain; relocalizes from bud neck to cytoplasm upon DNA replication stress; BOI2 has a paralog, BOI1, that arose from the whole genome duplication

NCBI Reference Sequences (RefSeq)

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Genome Annotation

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference assembly

Genomic

  1. NC_001137.3 Reference assembly

    Range
    390590..393712 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. NM_001179004.1 → NP_011039.1  TPA: Boi2p [Saccharomyces cerevisiae S288C]

    See identical proteins and their annotated locations for NP_011039.1

    Status: REVIEWED

    UniProtKB/Swiss-Prot
    D3DM20, P39969
    UniProtKB/TrEMBL
    B5VHP0
    Conserved Domains (3) summary
    cd09535
    Location:264 → 328
    SAM_BOI-like_fungal; SAM domain of BOI-like fungal subfamily
    cd11886
    Location:47 → 101
    SH3_BOI; Src Homology 3 domain of fungal BOI-like proteins
    cd13316
    Location:770 → 886
    PH_Boi; Boi family Pleckstrin homology domain
Nucleotide Protein
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
P39969.1

Gene LinkOut

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