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THO1 Tho1p [ Saccharomyces cerevisiae S288C ]

Gene ID: 856792, updated on 2-Nov-2024

Summary

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Official Symbol
THO1
Official Full Name
Tho1p
Primary source
SGD:S000000865
Locus tag
YER063W
See related
AllianceGenome:SGD:S000000865; FungiDB:YER063W; VEuPathDB:YER063W
Gene type
protein coding
RefSeq status
REVIEWED
Organism
Saccharomyces cerevisiae S288C (strain: S288C)
Lineage
Eukaryota; Fungi; Dikarya; Ascomycota; Saccharomycotina; Saccharomycetes; Saccharomycetales; Saccharomycetaceae; Saccharomyces
Summary
Enables RNA binding activity; chromatin binding activity; and double-stranded DNA binding activity. Involved in poly(A)+ mRNA export from nucleus; protein-RNA complex assembly; and transcription elongation by RNA polymerase II. Located in nucleus. [provided by Alliance of Genome Resources, Nov 2024]
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Genomic context

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See THO1 in Genome Data Viewer
Location:
chromosome: V
Exon count:
1
Sequence:
Chromosome: V; NC_001137.3 (281710..282366)

Chromosome V - NC_001137.3Genomic Context describing neighboring genes Neighboring gene fatty acid synthase CEM1 Neighboring gene glycerol-1-phosphatase HOR2 Neighboring gene Vhr2p Neighboring gene isocitrate lyase 1

Genomic regions, transcripts, and products

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Genomic Sequence:
NC_001137.3

Go to nucleotide: Graphics FASTA GenBank

Bibliography

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Related articles in PubMed

  1. High-resolution NMR structures of the domains of Saccharomyces cerevisiae Tho1. Jacobsen JO, et al. Acta Crystallogr F Struct Biol Commun, 2016 Jun. PMID 27303905, Free PMC Article
  2. Engineering a two-helix bundle protein for folding studies. Dodson CA, et al. Protein Eng Des Sel, 2010 May. PMID 20130106, Free PMC Article
  3. Structural basis for high-order complex of SARNP and DDX39B to facilitate mRNP assembly. Xie Y, et al. Cell Rep, 2023 Aug 29. PMID 37578863, Free PMC Article
  4. A novel yeast gene, THO2, is involved in RNA pol II transcription and provides new evidence for transcriptional elongation-associated recombination. Piruat JI, et al. EMBO J, 1998 Aug 17. PMID 9707445, Free PMC Article
  5. Tho1, a novel hnRNP, and Sub2 provide alternative pathways for mRNP biogenesis in yeast THO mutants. Jimeno S, et al. Mol Cell Biol, 2006 Jun. PMID 16738307, Free PMC Article

See all (38) citations in PubMed

GeneRIFs: Gene References Into Functions

What's a GeneRIF?
  1. Overexpression of Tho1 or Sub2 may provide alternative ways for mRNP formation and export in the absence of a functional THO complex.
    Title: Tho1, a novel hnRNP, and Sub2 provide alternative pathways for mRNP biogenesis in yeast THO mutants.
Submit: New GeneRIF Correction

Interactions

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Products Interactant Other Gene Complex Source Pubs Description

General gene information

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Homology

Gene Ontology Provided by SGD

Function Evidence Code Pubs
enables RNA binding IDA
Inferred from Direct Assay
more info
 PubMed 
enables chromatin binding IDA
Inferred from Direct Assay
more info
 PubMed 
enables double-stranded DNA binding IDA
Inferred from Direct Assay
more info
 PubMed 
Process Evidence Code Pubs
involved_in poly(A)+ mRNA export from nucleus IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in poly(A)+ mRNA export from nucleus IGI
Inferred from Genetic Interaction
more info
 PubMed 
involved_in protein-RNA complex assembly IMP
Inferred from Mutant Phenotype
more info
 PubMed 
involved_in transcription elongation by RNA polymerase II IGI
Inferred from Genetic Interaction
more info
 PubMed 
Component Evidence Code Pubs
located_in nucleus HDA PubMed 
is_active_in nucleus IBA
Inferred from Biological aspect of Ancestor
more info
  

General protein information

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Preferred Names
Tho1p
NP_010985.1
  • Conserved nuclear RNA-binding protein; specifically binds to transcribed chromatin in a THO- and RNA-dependent manner, genetically interacts with shuttling hnRNP NAB2; overproduction suppresses transcriptional defect caused by hpr1 mutation

NCBI Reference Sequences (RefSeq)

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Genome Annotation

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference assembly

Genomic

  1. NC_001137.3 Reference assembly

    Range
    281710..282366
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. NM_001178954.1 → NP_010985.1  TPA: Tho1p [Saccharomyces cerevisiae S288C]

    See identical proteins and their annotated locations for NP_010985.1

    Status: REVIEWED

    UniProtKB/Swiss-Prot
    D3DLW8, P40040
    UniProtKB/TrEMBL
    A6ZR17, B3LS77, C7GTD1, C8Z769, N1P6Y8
    Conserved Domains (3) summary
    PRK13108
    Location:39 → 109
    PRK13108; prolipoprotein diacylglyceryl transferase; Reviewed
    pfam02037
    Location:4 → 38
    SAP; SAP domain
    pfam18592
    Location:127 → 164
    Tho1_MOS11_C; Tho1/MOS11 C-terminal domain
Nucleotide Protein
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
P40040.1

Gene LinkOut

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