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PET117 Pet117p [ Saccharomyces cerevisiae S288C ]

Gene ID: 856786, updated on 28-Oct-2024

Summary

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Official Symbol
PET117
Official Full Name
Pet117p
Primary source
SGD:S000000860
Locus tag
YER058W
See related
AllianceGenome:SGD:S000000860; FungiDB:YER058W; VEuPathDB:YER058W
Gene type
protein coding
RefSeq status
REVIEWED
Organism
Saccharomyces cerevisiae S288C (strain: S288C)
Lineage
Eukaryota; Fungi; Dikarya; Ascomycota; Saccharomycotina; Saccharomycetes; Saccharomycetales; Saccharomycetaceae; Saccharomyces
Summary
Involved in mitochondrial cytochrome c oxidase assembly. Located in mitochondrion. Human ortholog(s) of this gene implicated in mitochondrial complex IV deficiency nuclear type 19. Orthologous to human PET117 (PET117 cytochrome c oxidase chaperone). [provided by Alliance of Genome Resources, Oct 2024]
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Genomic context

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See PET117 in Genome Data Viewer
Location:
chromosome: V
Exon count:
1
Sequence:
Chromosome: V; NC_001137.3 (271768..272091)

Chromosome V - NC_001137.3Genomic Context describing neighboring genes Neighboring gene ribosomal 60S subunit protein L34A Neighboring gene putative isoleucine biosynthesis protein HMF1 Neighboring gene Pcl6p Neighboring gene purine-cytosine permease

Genomic regions, transcripts, and products

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Genomic Sequence:
NC_001137.3

Go to nucleotide: Graphics FASTA GenBank

Bibliography

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Related articles in PubMed

  1. Evidence that the catalytic mechanism of heme a synthase involves the formation of a carbocation stabilized by a conserved glutamate. Rivett ED, et al. Arch Biochem Biophys, 2023 Aug. PMID 37348627, Free PMC Article
  2. Sequence and chromosomal localization of two PET genes required for cytochrome c oxidase assembly in Saccharomyces cerevisiae. McEwen JE, et al. Curr Genet, 1993 Jan. PMID 8381337
  3. Inhibition of electron transport chain assembly and function promotes photodynamic killing of Candida. Chabrier-Roselló Y, et al. J Photochem Photobiol B, 2010 Jun 1. PMID 20381373, Free PMC Article
  4. The Assembly Factor Pet117 Couples Heme a Synthase Activity to Cytochrome Oxidase Assembly. Taylor NG, et al. J Biol Chem, 2017 Feb 3. PMID 27998984, Free PMC Article
  5. Identification of respiratory chain gene mutations that shorten replicative life span in yeast. Hacioglu E, et al. Exp Gerontol, 2012 Feb. PMID 22137892

See all (32) citations in PubMed

GeneRIFs: Gene References Into Functions

Interactions

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Products Interactant Other Gene Complex Source Pubs Description

General gene information

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Homology

Gene Ontology Provided by SGD

Function Evidence Code Pubs
enables molecular_function ND
No biological Data available
more info
  
Process Evidence Code Pubs
involved_in mitochondrial cytochrome c oxidase assembly IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in mitochondrial cytochrome c oxidase assembly IMP
Inferred from Mutant Phenotype
more info
 PubMed 
Component Evidence Code Pubs
located_in mitochondrion HDA PubMed 
is_active_in mitochondrion IBA
Inferred from Biological aspect of Ancestor
more info
  
located_in mitochondrion IEA
Inferred from Electronic Annotation
more info
  

General protein information

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Preferred Names
Pet117p
NP_010979.1
  • Assembly factor that couples heme a synthesis to complex IV assembly; regulates the oligomerization state of the Cox15p heme a synthase, and couples this to the assembly of the cytochrome C oxidase complex (complex IV)

NCBI Reference Sequences (RefSeq)

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Genome Annotation

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference assembly

Genomic

  1. NC_001137.3 Reference assembly

    Range
    271768..272091
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. NM_001178949.1 → NP_010979.1  TPA: Pet117p [Saccharomyces cerevisiae S288C]

    See identical proteins and their annotated locations for NP_010979.1

    Status: REVIEWED

    UniProtKB/Swiss-Prot
    D3DLW2, Q02771
    UniProtKB/TrEMBL
    A6ZR11, B3LS73, C7GWI9, C8Z764, G2WCU5, N1P556
    Conserved Domains (1) summary
    pfam15786
    Location:5 → 88
    PET117; PET assembly of cytochrome c oxidase, mitochondrial
Nucleotide Protein
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
Q02771.1

Gene LinkOut

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