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SAH1 adenosylhomocysteinase [ Saccharomyces cerevisiae S288C ]

Gene ID: 856766, updated on 28-Oct-2024

Summary

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Official Symbol
SAH1
Official Full Name
adenosylhomocysteinase
Primary source
SGD:S000000845
Locus tag
YER043C
See related
AllianceGenome:SGD:S000000845; FungiDB:YER043C; VEuPathDB:YER043C
Gene type
protein coding
RefSeq status
REVIEWED
Organism
Saccharomyces cerevisiae S288C (strain: S288C)
Lineage
Eukaryota; Fungi; Dikarya; Ascomycota; Saccharomycotina; Saccharomycetes; Saccharomycetales; Saccharomycetaceae; Saccharomyces
Summary
Enables adenosylhomocysteinase activity. Involved in S-adenosylhomocysteine catabolic process; phosphatidylcholine biosynthetic process; and triglyceride metabolic process. Located in cytoplasm. Used to study hyperhomocysteinemia. Human ortholog(s) of this gene implicated in abdominal aortic aneurysm; hyperhomocysteinemia; and hypermethioninemia with deficiency of S-adenosylhomocysteine hydrolase. Orthologous to human AHCY (adenosylhomocysteinase). [provided by Alliance of Genome Resources, Oct 2024]
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Genomic context

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See SAH1 in Genome Data Viewer
Location:
chromosome: V
Exon count:
1
Sequence:
Chromosome: V; NC_001137.3 (235770..237119, complement)

Chromosome V - NC_001137.3Genomic Context describing neighboring genes Neighboring gene crossover junction endodeoxyribonuclease Neighboring gene peptide-methionine-S-sulfoxide reductase Neighboring gene Erg28p Neighboring gene Mei4p

Genomic regions, transcripts, and products

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Genomic Sequence:
NC_001137.3

Go to nucleotide: Graphics FASTA GenBank

Bibliography

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Related articles in PubMed

  1. Involvement of S-adenosylmethionine in G1 cell-cycle regulation in Saccharomyces cerevisiae. Mizunuma M, et al. Proc Natl Acad Sci U S A, 2004 Apr 20. PMID 15073333, Free PMC Article
  2. S-adenosyl-L-homocysteine hydrolase in yeast: key enzyme of methylation metabolism and coordinated regulation with phospholipid synthesis. Tehlivets O, et al. FEBS Lett, 2004 Nov 19. PMID 15556636
  3. Homocysteine regulates fatty acid and lipid metabolism in yeast. Visram M, et al. J Biol Chem, 2018 Apr 13. PMID 29414770, Free PMC Article
  4. Linking genome and proteome by mass spectrometry: large-scale identification of yeast proteins from two dimensional gels. Shevchenko A, et al. Proc Natl Acad Sci U S A, 1996 Dec 10. PMID 8962070, Free PMC Article
  5. S-adenosyl-L-homocysteine hydrolase, key enzyme of methylation metabolism, regulates phosphatidylcholine synthesis and triacylglycerol homeostasis in yeast: implications for homocysteine as a risk factor of atherosclerosis. Malanovic N, et al. J Biol Chem, 2008 Aug 29. PMID 18591246, Free PMC Article

See all (59) citations in PubMed

GeneRIFs: Gene References Into Functions

What's a GeneRIF?
  1. cells with down-regulated Sah1 activity major alterations in the expression of the INO1 gene as well as in the localization of Opi1, a negative regulatory factor of phospholipid synthesis
    Title: S-adenosyl-L-homocysteine hydrolase, key enzyme of methylation metabolism, regulates phosphatidylcholine synthesis and triacylglycerol homeostasis in yeast: implications for homocysteine as a risk factor of atherosclerosis.
Submit: New GeneRIF Correction

Pathways from PubChem

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Interactions

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Products Interactant Other Gene Complex Source Pubs Description

General gene information

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Homology

Gene Ontology Provided by SGD

Function Evidence Code Pubs
enables adenosylhomocysteinase activity IBA
Inferred from Biological aspect of Ancestor
more info
  
enables adenosylhomocysteinase activity IEA
Inferred from Electronic Annotation
more info
  
enables adenosylhomocysteinase activity IMP
Inferred from Mutant Phenotype
more info
 PubMed 
enables hydrolase activity IEA
Inferred from Electronic Annotation
more info
  
Process Evidence Code Pubs
involved_in S-adenosylhomocysteine catabolic process IMP
Inferred from Mutant Phenotype
more info
 PubMed 
involved_in S-adenosylmethionine cycle IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in one-carbon metabolic process IEA
Inferred from Electronic Annotation
more info
  
involved_in phosphatidylcholine biosynthetic process IMP
Inferred from Mutant Phenotype
more info
 PubMed 
involved_in triglyceride metabolic process IMP
Inferred from Mutant Phenotype
more info
 PubMed 
Component Evidence Code Pubs
located_in cytoplasm HDA PubMed 
is_active_in cytosol IBA
Inferred from Biological aspect of Ancestor
more info
  

General protein information

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Preferred Names
adenosylhomocysteinase
NP_010961.3
  • S-adenosyl-L-homocysteine hydrolase; catabolizes S-adenosyl-L-homocysteine which is formed after donation of the activated methyl group of S-adenosyl-L-methionine (AdoMet) to an acceptor; regulates cellular lipid homoeostasis by regulating phosphatidylcholine(PC)synthesis and triacylglycerol (TG) levels

NCBI Reference Sequences (RefSeq)

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Genome Annotation

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference assembly

Genomic

  1. NC_001137.3 Reference assembly

    Range
    235770..237119 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. NM_001178934.3 → NP_010961.3  TPA: adenosylhomocysteinase [Saccharomyces cerevisiae S288C]

    See identical proteins and their annotated locations for NP_010961.3

    Status: REVIEWED

    UniProtKB/Swiss-Prot
    D3DLU3, P39954
    UniProtKB/TrEMBL
    A6ZQZ2, B3LS56, B5VHH7, C7GSJ0, C8Z746, G2WCS6, N1P540
    Conserved Domains (1) summary
    smart00996
    Location:9 → 448
    AdoHcyase; S-adenosyl-L-homocysteine hydrolase
Nucleotide Protein
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
P39954.1

Gene LinkOut

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