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CHZ1 Chz1p [ Saccharomyces cerevisiae S288C ]

Gene ID: 856752, updated on 2-Nov-2024

Summary

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Official Symbol
CHZ1
Official Full Name
Chz1p
Primary source
SGD:S000000832
Locus tag
YER030W
See related
AllianceGenome:SGD:S000000832; FungiDB:YER030W; VEuPathDB:YER030W
Gene type
protein coding
RefSeq status
REVIEWED
Organism
Saccharomyces cerevisiae S288C (strain: S288C)
Lineage
Eukaryota; Fungi; Dikarya; Ascomycota; Saccharomycotina; Saccharomycetes; Saccharomycetales; Saccharomycetaceae; Saccharomyces
Summary
Enables histone binding activity. Involved in chromatin remodeling. Is active in nucleus. [provided by Alliance of Genome Resources, Nov 2024]
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Genomic context

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See CHZ1 in Genome Data Viewer
Location:
chromosome: V
Exon count:
1
Sequence:
Chromosome: V; NC_001137.3 (213437..213898)

Chromosome V - NC_001137.3Genomic Context describing neighboring genes Neighboring gene Mig3p Neighboring gene mRNA splicing protein SMB1 Neighboring gene Rab family GTPase YPT31 Neighboring gene Fir1p

Genomic regions, transcripts, and products

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Genomic Sequence:
NC_001137.3

Go to nucleotide: Graphics FASTA GenBank

Bibliography

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Related articles in PubMed

  1. Damage recovery pathways in Saccharomyces cerevisiae revealed by genomic phenotyping and interactome mapping. Begley TJ, et al. Mol Cancer Res, 2002 Dec. PMID 12496357
  2. Histone chaperone Chz1 facilitates the disfavouring property of Spt16 to H2A.Z-containing genes in Saccharomyces cerevisiae. Liu H, et al. Biochem J, 2014 Jun 15. PMID 24707933
  3. Distinct roles for histone chaperones in the deposition of Htz1 in chromatin. Liu H, et al. Biosci Rep, 2014 Sep 19. PMID 25338502, Free PMC Article
  4. NMR structure of chaperone Chz1 complexed with histones H2A.Z-H2B. Zhou Z, et al. Nat Struct Mol Biol, 2008 Aug. PMID 18641662, Free PMC Article
  5. Binding kinetics of histone chaperone Chz1 and variant histone H2A.Z-H2B by relaxation dispersion NMR spectroscopy. Hansen DF, et al. J Mol Biol, 2009 Mar 20. PMID 19385041, Free PMC Article

See all (44) citations in PubMed

GeneRIFs: Gene References Into Functions

What's a GeneRIF?
  1. these results define the distinct roles for histone chaperones Chz1 and Nap1 to regulate Htz1 incorporation into chromatin.
    Title: Distinct roles for histone chaperones in the deposition of Htz1 in chromatin.
  2. results suggest that the discrimination of Spt16 to Htz1-bound genes is due to the priority of Chz1 over Spt16 in binding to the Htz1-bound genomic regions; Chz1-escorted Htz1 therefore impairs Spt16 binding at chromatin
    Title: Histone chaperone Chz1 facilitates the disfavouring property of Spt16 to H2A.Z-containing genes in Saccharomyces cerevisiae.
  3. the histone chaperones Nap1 and Chz1 have separate Htz1-dependent and -independent functions
    Title: Nap1 and Chz1 have separate Htz1 nuclear import and assembly functions.
  4. analysis of the NMR structure of budding yeast chaperone Chz1 complexed with histones H2A.Z-H2B
    Title: NMR structure of chaperone Chz1 complexed with histones H2A.Z-H2B.
  5. Chz1 is a histone chaperone protein that has preference for histone H2AZ.
    Title: Chz1, a nuclear chaperone for histone H2AZ.
Submit: New GeneRIF Correction

Interactions

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Products Interactant Other Gene Complex Source Pubs Description

General gene information

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Homology

Gene Ontology Provided by SGD

Function Evidence Code Pubs
enables histone binding IPI
Inferred from Physical Interaction
more info
 PubMed 
Process Evidence Code Pubs
involved_in chromatin remodeling IPI
Inferred from Physical Interaction
more info
 PubMed 
Component Evidence Code Pubs
is_active_in nucleus HDA PubMed 
is_active_in nucleus IDA
Inferred from Direct Assay
more info
 PubMed 
located_in nucleus IEA
Inferred from Electronic Annotation
more info
  

General protein information

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Preferred Names
Chz1p
NP_010947.2
  • Histone chaperone for Htz1p/H2A-H2B dimer; required for the stabilization of the Chz1p-Htz1-H2B complex; has overlapping function with Nap1p; null mutant displays weak sensitivity to MMS and benomyl; contains a highly conserved CHZ motif; protein abundance increases in response to DNA replication stress

NCBI Reference Sequences (RefSeq)

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Genome Annotation

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference assembly

Genomic

  1. NC_001137.3 Reference assembly

    Range
    213437..213898
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. NM_001178921.1 → NP_010947.2  TPA: Chz1p [Saccharomyces cerevisiae S288C]

    See identical proteins and their annotated locations for NP_010947.2

    Status: REVIEWED

    UniProtKB/Swiss-Prot
    D3DLS9, P40019
    UniProtKB/TrEMBL
    G2WCR3, N1P6V3
    Conserved Domains (1) summary
    pfam09649
    Location:97 → 120
    CHZ; Histone chaperone domain CHZ
Nucleotide Protein
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
P40019.2

Gene LinkOut

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