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SPC25 [ Saccharomyces cerevisiae S288C ]

Gene ID: 856738, updated on 22-Aug-2024

Summary

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Official Symbol
SPC25
Primary source
FungiDB:YER018C
Locus tag
YER018C
See related
SGD:S000000820; AllianceGenome:SGD:S000000820; VEuPathDB:YER018C
Gene type
protein coding
RefSeq status
REVIEWED
Organism
Saccharomyces cerevisiae S288C (strain: S288C)
Lineage
Eukaryota; Fungi; Dikarya; Ascomycota; Saccharomycotina; Saccharomycetes; Saccharomycetales; Saccharomycetaceae; Saccharomyces
Summary
Involved in centromere clustering and chromosome segregation. Located in kinetochore. Part of Ndc80 complex. [provided by Alliance of Genome Resources, Apr 2022]
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Genomic context

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Location:
chromosome: V
Exon count:
1
Sequence:
Chromosome: V; NC_001137.3 (191959..192624, complement)

Chromosome V - NC_001137.3Genomic Context describing neighboring genes Neighboring gene microtubule-binding protein BIM1 Neighboring gene AAA family ATPase AFG3 Neighboring gene inositol phosphosphingolipid phospholipase Neighboring gene Arf family guanine nucleotide exchange factor SBH2

Genomic regions, transcripts, and products

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Genomic Sequence:
NC_001137.3

Go to nucleotide: Graphics FASTA GenBank

Bibliography

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Related articles in PubMed

  1. Structure of a central component of the yeast kinetochore: the Spc24p/Spc25p globular domain. Wei RR, et al. Structure, 2006 Jun. PMID 16765893
  2. Methylation of CENP-A/Cse4 on arginine 143 and lysine 131 regulates kinetochore stability in yeast. Tran Nguyen TM, et al. Genetics, 2023 Apr 6. PMID 36810679, Free PMC Article
  3. RWD domain: a recurring module in kinetochore architecture shown by a Ctf19-Mcm21 complex structure. Schmitzberger F, et al. EMBO Rep, 2012 Mar 1. PMID 22322944, Free PMC Article
  4. Tight bending of the Ndc80 complex provides intrinsic regulation of its binding to microtubules. Scarborough EA, et al. Elife, 2019 May 2. PMID 31045495, Free PMC Article
  5. Conserved Tetramer Junction in the Kinetochore Ndc80 Complex. Valverde R, et al. Cell Rep, 2016 Nov 15. PMID 27851957, Free PMC Article

See all (61) citations in PubMed

GeneRIFs: Gene References Into Functions

Interactions

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Products Interactant Other Gene Complex Source Pubs Description

General gene information

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Homology

Gene Ontology Provided by SGD

Function Evidence Code Pubs
enables molecular_function ND
No biological Data available
more info
  
Process Evidence Code Pubs
involved_in cell division IEA
Inferred from Electronic Annotation
more info
  
involved_in centromere clustering IMP
Inferred from Mutant Phenotype
more info
 PubMed 
involved_in chromosome segregation IMP
Inferred from Mutant Phenotype
more info
 PubMed 
Component Evidence Code Pubs
part_of Ndc80 complex IDA
Inferred from Direct Assay
more info
 PubMed 
part_of Ndc80 complex IPI
Inferred from Physical Interaction
more info
 PubMed 
located_in chromosome IEA
Inferred from Electronic Annotation
more info
  
located_in chromosome, centromeric region IEA
Inferred from Electronic Annotation
more info
  
located_in kinetochore IDA
Inferred from Direct Assay
more info
 PubMed 
located_in kinetochore IEA
Inferred from Electronic Annotation
more info
  
located_in kinetochore IMP
Inferred from Mutant Phenotype
more info
 PubMed 
located_in nucleus IEA
Inferred from Electronic Annotation
more info
  

General protein information

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Preferred Names
kinetochore-associated Ndc80 complex subunit SPC25
NP_010934.3
  • Component of the kinetochore-associated Ndc80 complex; involved in chromosome segregation, spindle checkpoint activity, and kinetochore clustering; evolutionarily conserved; other members include Ndc80p, Nuf2p, Spc24p, and Spc25p

NCBI Reference Sequences (RefSeq)

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Genome Annotation

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference assembly

Genomic

  1. NC_001137.3 Reference assembly

    Range
    191959..192624 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. NM_001178909.3 → NP_010934.3  TPA: kinetochore-associated Ndc80 complex subunit SPC25 [Saccharomyces cerevisiae S288C]

    See identical proteins and their annotated locations for NP_010934.3

    Status: REVIEWED

    UniProtKB/Swiss-Prot
    D3DLR6, P40014
    UniProtKB/TrEMBL
    A6ZQW6, G2WCQ0, N1P5R5
    Conserved Domains (1) summary
    PRK00286
    Location:8 → 131
    xseA; exodeoxyribonuclease VII large subunit; Reviewed
Nucleotide Protein
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
P40014.1

Gene LinkOut

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