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[ Saccharomyces cerevisiae S288C ]

Gene ID: 856617, updated on 11-Sep-2024

Summary

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Primary source
SGD:S000001253
Locus tag
YHR210C
See related
AllianceGenome:SGD:S000001253; FungiDB:YHR210C; VEuPathDB:YHR210C
Gene type
protein coding
RefSeq status
REVIEWED
Organism
Saccharomyces cerevisiae S288C (strain: S288C)
Lineage
Eukaryota; Fungi; Dikarya; Ascomycota; Saccharomycotina; Saccharomycetes; Saccharomycetales; Saccharomycetaceae; Saccharomyces
Summary
Predicted to enable aldose 1-epimerase activity. Predicted to be involved in galactose catabolic process via UDP-galactose and glucose metabolic process. Human ortholog(s) of this gene implicated in galactosemia. Orthologous to human GALM (galactose mutarotase). [provided by Alliance of Genome Resources, Apr 2022]
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Genomic context

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Location:
chromosome: VIII
Exon count:
1
Sequence:
Chromosome: VIII; NC_001140.6 (520712..521737, complement)

Chromosome VIII - NC_001140.6Genomic Context describing neighboring genes Neighboring gene branched-chain-amino-acid transaminase BAT1 Neighboring gene S-adenosylmethionine-dependent methyltransferase Neighboring gene flocculin FLO5 Neighboring gene uncharacterized protein

Genomic regions, transcripts, and products

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Genomic Sequence:
NC_001140.6

Go to nucleotide: Graphics FASTA GenBank

Bibliography

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Related articles in PubMed

  1. UDPgalactose 4-epimerase from Saccharomyces cerevisiae. A bifunctional enzyme with aldose 1-epimerase activity. Majumdar S, et al. Eur J Biochem, 2004 Feb. PMID 14764091
  2. Investigation of the functional role of aldose 1-epimerase in engineered cellobiose utilization. Li S, et al. J Biotechnol, 2013 Oct 10. PMID 23954547
  3. Genome-wide transcriptional analysis of aerobic and anaerobic chemostat cultures of Saccharomyces cerevisiae. ter Linde JJ, et al. J Bacteriol, 1999 Dec. PMID 10601195, Free PMC Article
  4. Functional genetic discovery of enzymes using full-scan mass spectrometry metabolomics (1). Caudy AA, et al. Biochem Cell Biol, 2019 Feb. PMID 30001498
  5. Defining the specificity of cotranslationally acting chaperones by systematic analysis of mRNAs associated with ribosome-nascent chain complexes. del Alamo M, et al. PLoS Biol, 2011 Jul. PMID 21765803, Free PMC Article

See all (17) citations in PubMed

GeneRIFs: Gene References Into Functions

Interactions

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Products Interactant Other Gene Complex Source Pubs Description

General gene information

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Homology

Gene Ontology Provided by SGD

Function Evidence Code Pubs
enables aldose 1-epimerase activity IBA
Inferred from Biological aspect of Ancestor
more info
  
enables carbohydrate binding IEA
Inferred from Electronic Annotation
more info
  
enables isomerase activity IEA
Inferred from Electronic Annotation
more info
  
enables molecular_function ND
No biological Data available
more info
  
Process Evidence Code Pubs
involved_in biological_process ND
No biological Data available
more info
  
involved_in carbohydrate metabolic process IEA
Inferred from Electronic Annotation
more info
  
involved_in galactose catabolic process via UDP-galactose IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in glucose metabolic process IBA
Inferred from Biological aspect of Ancestor
more info
  
Component Evidence Code Pubs
is_active_in cellular_component ND
No biological Data available
more info
  

General protein information

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Preferred Names
aldose 1-epimerase superfamily protein
NP_012080.3
  • Putative aldose 1-epimerase superfamily protein; non-essential gene; highly expressed under anaeorbic conditions

NCBI Reference Sequences (RefSeq)

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Genome Annotation

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference assembly

Genomic

  1. NC_001140.6 Reference assembly

    Range
    520712..521737 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. NM_001179341.3 → NP_012080.3  TPA: aldose 1-epimerase superfamily protein [Saccharomyces cerevisiae S288C]

    Status: REVIEWED

    UniProtKB/Swiss-Prot
    D3DLF9, P38893
    UniProtKB/TrEMBL
    A6ZTB7, B3LSX1, C7GN95, N1P9J1
    Conserved Domains (1) summary
    cd09019
    Location:13 → 339
    galactose_mutarotase_like; galactose mutarotase_like
Nucleotide Protein
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
P38893.1

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