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EGD2 Egd2p [ Saccharomyces cerevisiae S288C ]

Gene ID: 856600, updated on 3-Nov-2024

Summary

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Official Symbol
EGD2
Official Full Name
Egd2p
Primary source
SGD:S000001236
Locus tag
YHR193C
See related
AllianceGenome:SGD:S000001236; FungiDB:YHR193C; VEuPathDB:YHR193C
Gene type
protein coding
RefSeq status
REVIEWED
Organism
Saccharomyces cerevisiae S288C (strain: S288C)
Lineage
Eukaryota; Fungi; Dikarya; Ascomycota; Saccharomycotina; Saccharomycetes; Saccharomycetales; Saccharomycetaceae; Saccharomyces
Summary
Enables phospholipid binding activity and unfolded protein binding activity. Involved in cotranslational protein targeting to membrane. Part of nascent polypeptide-associated complex. Orthologous to several human genes including NACA2 (nascent polypeptide associated complex subunit alpha 2). [provided by Alliance of Genome Resources, Nov 2024]
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Genomic context

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See EGD2 in Genome Data Viewer
Location:
chromosome: VIII
Exon count:
1
Sequence:
Chromosome: VIII; NC_001140.6 (487712..488236, complement)

Chromosome VIII - NC_001140.6Genomic Context describing neighboring genes Neighboring gene Ctf8p Neighboring gene Lnp1p Neighboring gene Mdm31p Neighboring gene Nvj1p

Genomic regions, transcripts, and products

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Genomic Sequence:
NC_001140.6

Go to nucleotide: Graphics FASTA GenBank

Bibliography

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Related articles in PubMed

  1. The yeast EGD2 gene encodes a homologue of the alpha NAC subunit of the human nascent-polypeptide-associated complex. Shi X, et al. Gene, 1995 Nov 20. PMID 8522175
  2. Evidence for a nuclear passage of nascent polypeptide-associated complex subunits in yeast. Franke J, et al. J Cell Sci, 2001 Jul. PMID 11683391
  3. OM14 is a mitochondrial receptor for cytosolic ribosomes that supports co-translational import into mitochondria. Lesnik C, et al. Nat Commun, 2014 Dec 9. PMID 25487825, Free PMC Article
  4. Dysfunctional nascent polypeptide-associated complex (NAC) activity in ribosomes enhances adriamycin toxicity in budding yeast. Takahashi T, et al. J Toxicol Sci, 2009 Dec. PMID 19952507
  5. The yeast nascent polypeptide-associated complex initiates protein targeting to mitochondria in vivo. George R, et al. Proc Natl Acad Sci U S A, 1998 Mar 3. PMID 9482879, Free PMC Article

See all (95) citations in PubMed

GeneRIFs: Gene References Into Functions

What's a GeneRIF?
  1. Dysfunctional nascent polypeptide-associated complex (NAC) activity in ribosomes enhances adriamycin toxicity in budding yeast.
    Title: Dysfunctional nascent polypeptide-associated complex (NAC) activity in ribosomes enhances adriamycin toxicity in budding yeast.
Submit: New GeneRIF Correction

Interactions

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Products Interactant Other Gene Complex Source Pubs Description

General gene information

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Homology

Gene Ontology Provided by SGD

Function Evidence Code Pubs
enables phosphatidic acid binding IDA
Inferred from Direct Assay
more info
 PubMed 
enables phosphatidylinositol-3,5-bisphosphate binding IDA
Inferred from Direct Assay
more info
 PubMed 
enables phosphatidylinositol-3-phosphate binding IDA
Inferred from Direct Assay
more info
 PubMed 
enables phosphatidylinositol-4-phosphate binding IDA
Inferred from Direct Assay
more info
 PubMed 
enables unfolded protein binding IBA
Inferred from Biological aspect of Ancestor
more info
  
enables unfolded protein binding IMP
Inferred from Mutant Phenotype
more info
 PubMed 
Process Evidence Code Pubs
involved_in cotranslational protein targeting to membrane IGI
Inferred from Genetic Interaction
more info
 PubMed 
involved_in protein targeting to membrane IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in protein transport IEA
Inferred from Electronic Annotation
more info
  
Component Evidence Code Pubs
is_active_in cytoplasm IBA
Inferred from Biological aspect of Ancestor
more info
  
located_in cytoplasm IEA
Inferred from Electronic Annotation
more info
  
part_of nascent polypeptide-associated complex IDA
Inferred from Direct Assay
more info
 PubMed 
part_of nascent polypeptide-associated complex IEA
Inferred from Electronic Annotation
more info
  
located_in nucleus IEA
Inferred from Electronic Annotation
more info
  

General protein information

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Preferred Names
Egd2p
NP_012063.3
  • Alpha subunit of the nascent polypeptide-associated complex (NAC); involved in protein sorting and translocation; associated with cytoplasmic ribosomes

NCBI Reference Sequences (RefSeq)

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Genome Annotation

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference assembly

Genomic

  1. NC_001140.6 Reference assembly

    Range
    487712..488236 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. NM_001179324.3 → NP_012063.3  TPA: Egd2p [Saccharomyces cerevisiae S288C]

    See identical proteins and their annotated locations for NP_012063.3

    Status: REVIEWED

    UniProtKB/Swiss-Prot
    A6ZT99, D3DLE1, P38879
    UniProtKB/TrEMBL
    B3LSV4, B5VKC1, C7GRL5, C8Z9Z2, G2WFR6, N1P9I5
    Conserved Domains (1) summary
    COG1308
    Location:3 → 174
    EGD2; Transcription factor homologous to NACalpha-BTF3 [Transcription]
Nucleotide Protein
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
P38879.3

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