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SOL3 6-phosphogluconolactonase SOL3 [ Saccharomyces cerevisiae S288C ]

Gene ID: 856568, updated on 2-Nov-2024

Summary

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Official Symbol
SOL3
Official Full Name
6-phosphogluconolactonase SOL3
Primary source
SGD:S000001206
Locus tag
YHR163W
See related
AllianceGenome:SGD:S000001206; FungiDB:YHR163W; VEuPathDB:YHR163W
Gene type
protein coding
RefSeq status
REVIEWED
Organism
Saccharomyces cerevisiae S288C (strain: S288C)
Lineage
Eukaryota; Fungi; Dikarya; Ascomycota; Saccharomycotina; Saccharomycetes; Saccharomycetales; Saccharomycetaceae; Saccharomyces
Summary
Enables 6-phosphogluconolactonase activity. Predicted to be involved in pentose-phosphate shunt, oxidative branch. Located in cytoplasm and nucleus. Orthologous to human PGLS (6-phosphogluconolactonase). [provided by Alliance of Genome Resources, Nov 2024]
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Genomic context

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See SOL3 in Genome Data Viewer
Location:
chromosome: VIII
Exon count:
1
Sequence:
Chromosome: VIII; NC_001140.6 (423724..424473)

Chromosome VIII - NC_001140.6Genomic Context describing neighboring genes Neighboring gene Yap1801p Neighboring gene mitochondrial pyruvate carrier Neighboring gene bifunctional ATP-dependent DNA helicase/ssDNA endodeoxyribonuclease DNA2 Neighboring gene U4/U6-U5 snRNP complex subunit PRP8

Genomic regions, transcripts, and products

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Genomic Sequence:
NC_001140.6

Go to nucleotide: Graphics FASTA GenBank

Bibliography

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Related articles in PubMed

  1. Molecular analysis of a Saccharomyces cerevisiae mutant with improved ability to utilize xylose shows enhanced expression of proteins involved in transport, initial xylose metabolism, and the pentose phosphate pathway. Wahlbom CF, et al. Appl Environ Microbiol, 2003 Feb. PMID 12570990, Free PMC Article
  2. Los1p, involved in yeast pre-tRNA splicing, positively regulates members of the SOL gene family. Shen WC, et al. Genetics, 1996 Jun. PMID 8725220, Free PMC Article
  3. Division of labor among the yeast Sol proteins implicated in tRNA nuclear export and carbohydrate metabolism. Stanford DR, et al. Genetics, 2004 Sep. PMID 15454531, Free PMC Article
  4. Identification of common traits in improved xylose-growing Saccharomyces cerevisiae for inverse metabolic engineering. Bengtsson O, et al. Yeast, 2008 Nov. PMID 19061191
  5. Inhibition of triosephosphate isomerase by phosphoenolpyruvate in the feedback-regulation of glycolysis. Grüning NM, et al. Open Biol, 2014 Mar 5. PMID 24598263, Free PMC Article

See all (29) citations in PubMed

GeneRIFs: Gene References Into Functions

Pathways from PubChem

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Interactions

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Products Interactant Other Gene Complex Source Pubs Description

General gene information

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Homology

Gene Ontology Provided by SGD

Function Evidence Code Pubs
enables 6-phosphogluconolactonase activity IBA
Inferred from Biological aspect of Ancestor
more info
  
enables 6-phosphogluconolactonase activity IEA
Inferred from Electronic Annotation
more info
  
enables 6-phosphogluconolactonase activity IGI
Inferred from Genetic Interaction
more info
 PubMed 
enables hydrolase activity IEA
Inferred from Electronic Annotation
more info
  
Process Evidence Code Pubs
involved_in carbohydrate metabolic process IEA
Inferred from Electronic Annotation
more info
  
involved_in pentose-phosphate shunt IEA
Inferred from Electronic Annotation
more info
  
involved_in pentose-phosphate shunt, oxidative branch IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in pentose-phosphate shunt, oxidative branch IC
Inferred by Curator
more info
 PubMed 
Component Evidence Code Pubs
located_in cytoplasm HDA PubMed 
located_in cytoplasm IEA
Inferred from Electronic Annotation
more info
  
is_active_in cytosol IBA
Inferred from Biological aspect of Ancestor
more info
  
located_in nucleus HDA PubMed 
located_in nucleus IEA
Inferred from Electronic Annotation
more info
  

General protein information

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Preferred Names
6-phosphogluconolactonase SOL3
NP_012033.2
  • 6-phosphogluconolactonase; catalyzes the second step of the pentose phosphate pathway; weak multicopy suppressor of los1-1 mutation; homologous to Sol2p and Sol1p; SOL3 has a paralog, SOL4, that arose from the whole genome duplication

NCBI Reference Sequences (RefSeq)

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Genome Annotation

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference assembly

Genomic

  1. NC_001140.6 Reference assembly

    Range
    423724..424473
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. NM_001179294.1 → NP_012033.2  TPA: 6-phosphogluconolactonase SOL3 [Saccharomyces cerevisiae S288C]

    See identical proteins and their annotated locations for NP_012033.2

    Status: REVIEWED

    UniProtKB/Swiss-Prot
    A6ZT71, B3LSS7, B5VK90, D3DLB2, P38858
    UniProtKB/TrEMBL
    C8Z9W0, G2WFN7, N1P192
    Conserved Domains (1) summary
    TIGR01198
    Location:6 → 244
    pgl; 6-phosphogluconolactonase
Nucleotide Protein
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
P38858.2

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