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ECM14 [ Saccharomyces cerevisiae S288C ]

Gene ID: 856533, updated on 22-Aug-2024

Summary

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Official Symbol
ECM14
Primary source
FungiDB:YHR132C
Locus tag
YHR132C
See related
SGD:S000001174; AllianceGenome:SGD:S000001174; VEuPathDB:YHR132C
Gene type
protein coding
RefSeq status
REVIEWED
Organism
Saccharomyces cerevisiae S288C (strain: S288C)
Lineage
Eukaryota; Fungi; Dikarya; Ascomycota; Saccharomycotina; Saccharomycetes; Saccharomycetales; Saccharomycetaceae; Saccharomyces
Summary
Predicted to enable metallocarboxypeptidase activity. Predicted to be involved in proteolysis. Predicted to be located in extracellular region and vacuole. Predicted to be active in extracellular space. Human ortholog(s) of this gene implicated in chronic kidney disease; familial febrile seizures 11; and familial temporal lobe epilepsy 5. Orthologous to several human genes including CPA4 (carboxypeptidase A4). [provided by Alliance of Genome Resources, Apr 2022]
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Genomic context

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Location:
chromosome: VIII
Exon count:
1
Sequence:
Chromosome: VIII; NC_001140.6 (368502..369794, complement)

Chromosome VIII - NC_001140.6Genomic Context describing neighboring genes Neighboring gene uncharacterized protein Neighboring gene uncharacterized protein Neighboring gene phosphatase regulator Neighboring gene Nsg1p

Genomic regions, transcripts, and products

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Genomic Sequence:
NC_001140.6

Go to nucleotide: Graphics FASTA GenBank

Bibliography

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Related articles in PubMed

  1. Biochemical and genetic analysis of Ecm14, a conserved fungal pseudopeptidase. McDonald RC, et al. BMC Mol Cell Biol, 2020 Nov 30. PMID 33256608, Free PMC Article
  2. Enhanced peptide secretion by gene disruption of CYM1, a novel protease in Saccharomyces cerevisiae. Jønson L, et al. Eur J Biochem, 2004 Dec. PMID 15606766
  3. Large scale identification of genes involved in cell surface biosynthesis and architecture in Saccharomyces cerevisiae. Lussier M, et al. Genetics, 1997 Oct. PMID 9335584, Free PMC Article
  4. The yeast vacuolar membrane proteome. Wiederhold E, et al. Mol Cell Proteomics, 2009 Feb. PMID 19001347
  5. Identifying Interaction Partners of Yeast Protein Disulfide Isomerases Using a Small Thiol-Reactive Cross-Linker: Implications for Secretory Pathway Proteostasis. Freije BJ, et al. Chem Res Toxicol, 2022 Feb 21. PMID 35084835, Free PMC Article

See all (25) citations in PubMed

GeneRIFs: Gene References Into Functions

Interactions

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Products Interactant Other Gene Complex Source Pubs Description

General gene information

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Homology

Gene Ontology Provided by SGD

Function Evidence Code Pubs
enables metal ion binding IEA
Inferred from Electronic Annotation
more info
  
NOT enables metallocarboxypeptidase activity IBA
Inferred from Biological aspect of Ancestor
more info
  
enables zinc ion binding IEA
Inferred from Electronic Annotation
more info
  
enables zinc ion binding RCA
inferred from Reviewed Computational Analysis
more info
 PubMed 
Process Evidence Code Pubs
involved_in cell wall organization IEA
Inferred from Electronic Annotation
more info
  
NOT involved_in proteolysis IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in proteolysis ISS
Inferred from Sequence or Structural Similarity
more info
 PubMed 
Component Evidence Code Pubs
located_in extracellular region IEA
Inferred from Electronic Annotation
more info
  
is_active_in extracellular space IBA
Inferred from Biological aspect of Ancestor
more info
  
is_active_in fungal-type vacuole HDA PubMed 
located_in vacuole IEA
Inferred from Electronic Annotation
more info
  

General protein information

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Preferred Names
putative metallocarboxypeptidase
NP_012000.1
  • Conserved fungal protein with similarity to zinc carboxypeptidases; in some strains required for normal cell wall assembly

NCBI Reference Sequences (RefSeq)

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Genome Annotation

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference assembly

Genomic

  1. NC_001140.6 Reference assembly

    Range
    368502..369794 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. NM_001179262.1 → NP_012000.1  TPA: putative metallocarboxypeptidase [Saccharomyces cerevisiae S288C]

    See identical proteins and their annotated locations for NP_012000.1

    Status: REVIEWED

    UniProtKB/Swiss-Prot
    D3DL80, P38836
    UniProtKB/TrEMBL
    A6ZT39, B3LSP5, C7GR75, C8Z9S6, G2WFK4, N1P2B0
    Conserved Domains (1) summary
    cd03860
    Location:121 → 425
    M14_CP_A-B_like; Peptidase M14 carboxypeptidase subfamily A/B-like
Nucleotide Protein
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
P38836.1

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