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YPT35 Ypt35p [ Saccharomyces cerevisiae S288C ]

Gene ID: 856505, updated on 18-Sep-2024

Summary

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Official Symbol
YPT35
Official Full Name
Ypt35p
Primary source
SGD:S000001147
Locus tag
YHR105W
See related
AllianceGenome:SGD:S000001147; FungiDB:YHR105W; VEuPathDB:YHR105W
Gene type
protein coding
RefSeq status
REVIEWED
Organism
Saccharomyces cerevisiae S288C (strain: S288C)
Lineage
Eukaryota; Fungi; Dikarya; Ascomycota; Saccharomycotina; Saccharomycetes; Saccharomycetales; Saccharomycetaceae; Saccharomyces
Summary
Enables phosphatidylinositol-3-phosphate binding activity. Located in endosome. Orthologous to human SNX16 (sorting nexin 16). [provided by Alliance of Genome Resources, Apr 2022]
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Genomic context

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See YPT35 in Genome Data Viewer
Location:
chromosome: VIII
Exon count:
1
Sequence:
Chromosome: VIII; NC_001140.6 (324766..325410)

Chromosome VIII - NC_001140.6Genomic Context describing neighboring genes Neighboring gene Sbe22p Neighboring gene trifunctional aldehyde reductase/xylose reductase/glucose 1-dehydrogenase (NADP(+)) Neighboring gene thioredoxin-disulfide reductase TRR2 Neighboring gene septin CDC12

Genomic regions, transcripts, and products

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Genomic Sequence:
NC_001140.6

Go to nucleotide: Graphics FASTA GenBank

Bibliography

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Related articles in PubMed

  1. Genetic Dissection of Vps13 Regulation in Yeast Using Disease Mutations from Human Orthologs. Park JS, et al. Int J Mol Sci, 2021 Jun 8. PMID 34201352, Free PMC Article
  2. A VPS13D spastic ataxia mutation disrupts the conserved adaptor-binding site in yeast Vps13. Dziurdzik SK, et al. Hum Mol Genet, 2020 Mar 13. PMID 31943017, Free PMC Article
  3. Competitive organelle-specific adaptors recruit Vps13 to membrane contact sites. Bean BDM, et al. J Cell Biol, 2018 Oct 1. PMID 30018089, Free PMC Article
  4. All phox homology (PX) domains from Saccharomyces cerevisiae specifically recognize phosphatidylinositol 3-phosphate. Yu JW, et al. J Biol Chem, 2001 Nov 23. PMID 11557775
  5. The phosphoinositide 3-kinase Vps34p is required for pexophagy in Saccharomyces cerevisiae. Grunau S, et al. Biochem J, 2011 Feb 15. PMID 21121900

See all (27) citations in PubMed

GeneRIFs: Gene References Into Functions

Interactions

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Products Interactant Other Gene Complex Source Pubs Description

General gene information

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Homology

Gene Ontology Provided by SGD

Function Evidence Code Pubs
enables phosphatidylinositol binding IEA
Inferred from Electronic Annotation
more info
  
enables phosphatidylinositol-3-phosphate binding IDA
Inferred from Direct Assay
more info
 PubMed 
enables phosphatidylinositol-3-phosphate binding IEA
Inferred from Electronic Annotation
more info
  
Process Evidence Code Pubs
involved_in biological_process ND
No biological Data available
more info
  
Component Evidence Code Pubs
located_in endosome HDA PubMed 
located_in endosome IEA
Inferred from Electronic Annotation
more info
  
located_in endosome membrane IEA
Inferred from Electronic Annotation
more info
  
located_in membrane IEA
Inferred from Electronic Annotation
more info
  
located_in vacuolar membrane IEA
Inferred from Electronic Annotation
more info
  
located_in vacuole IEA
Inferred from Electronic Annotation
more info
  

General protein information

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Preferred Names
Ypt35p
NP_011973.1
  • Endosomal hypothetical protein; contains a phox (PX) homology domain; binds to both phosphatidylinositol-3-phosphate (PtdIns(3)P) and proteins involved in ER-Golgi or vesicular transport

NCBI Reference Sequences (RefSeq)

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Genome Annotation

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference assembly

Genomic

  1. NC_001140.6 Reference assembly

    Range
    324766..325410
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. NM_001179235.1 → NP_011973.1  TPA: Ypt35p [Saccharomyces cerevisiae S288C]

    See identical proteins and their annotated locations for NP_011973.1

    Status: REVIEWED

    UniProtKB/Swiss-Prot
    A6ZT13, D3DL55, P38815
    UniProtKB/TrEMBL
    B3LSM0, B5VK40, C7GLZ1, C8Z9P8, G2WFH9, N1P9E9
    Conserved Domains (1) summary
    cd07280
    Location:73 → 209
    PX_YPT35; The phosphoinositide binding Phox Homology domain of the fungal protein YPT35
Nucleotide Protein
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
P38815.1

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