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CIC1 Cic1p [ Saccharomyces cerevisiae S288C ]

Gene ID: 856449, updated on 18-Sep-2024

Summary

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Official Symbol
CIC1
Official Full Name
Cic1p
Primary source
SGD:S000001094
Locus tag
YHR052W
See related
AllianceGenome:SGD:S000001094; FungiDB:YHR052W; VEuPathDB:YHR052W
Gene type
protein coding
RefSeq status
REVIEWED
Organism
Saccharomyces cerevisiae S288C (strain: S288C)
Lineage
Eukaryota; Fungi; Dikarya; Ascomycota; Saccharomycotina; Saccharomycetes; Saccharomycetales; Saccharomycetaceae; Saccharomyces
Also known as
NSA3
Summary
Enables large ribosomal subunit rRNA binding activity; proteasome binding activity; and protein-macromolecule adaptor activity. Involved in maturation of 5.8S rRNA from tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA); maturation of LSU-rRNA from tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA); and protein catabolic process. Located in nucleolus. Part of preribosome, large subunit precursor. Orthologous to human RSL1D1 (ribosomal L1 domain containing 1). [provided by Alliance of Genome Resources, Apr 2022]
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Genomic context

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See CIC1 in Genome Data Viewer
Location:
chromosome: VIII
Exon count:
1
Sequence:
Chromosome: VIII; NC_001140.6 (210848..211978)

Chromosome VIII - NC_001140.6Genomic Context describing neighboring genes Neighboring gene uncharacterized protein Neighboring gene cytochrome c oxidase subunit VI Neighboring gene uncharacterized protein Neighboring gene ncRNA Neighboring gene metallothionein CUP1 Neighboring gene uncharacterized protein

Genomic regions, transcripts, and products

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Genomic Sequence:
NC_001140.6

Go to nucleotide: Graphics FASTA GenBank

Bibliography

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Related articles in PubMed

  1. Cic1p/Nsa3p is required for synthesis and nuclear export of 60S ribosomal subunits. Fatica A, et al. RNA, 2003 Dec. PMID 14623999, Free PMC Article
  2. Structure and RNA recognition of ribosome assembly factor Utp30. Hu J, et al. RNA, 2017 Dec. PMID 28951391, Free PMC Article
  3. Structures of naturally evolved CUP1 tandem arrays in yeast indicate that these arrays are generated by unequal nonhomologous recombination. Zhao Y, et al. G3 (Bethesda), 2014 Sep 17. PMID 25236733, Free PMC Article
  4. Cic1, an adaptor protein specifically linking the 26S proteasome to its substrate, the SCF component Cdc4. Jäger S, et al. EMBO J, 2001 Aug 15. PMID 11500370, Free PMC Article
  5. Multicopy suppression screen in the msb3 msb4 Saccharomyces cerevisiae double mutant, affected in Ypt/RabGAP activity. Dechamps C, et al. Biotechnol Lett, 2005 Oct. PMID 16231214

See all (111) citations in PubMed

GeneRIFs: Gene References Into Functions

Interactions

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Products Interactant Other Gene Complex Source Pubs Description

General gene information

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Homology

Gene Ontology Provided by SGD

Function Evidence Code Pubs
enables RNA binding IBA
Inferred from Biological aspect of Ancestor
more info
  
enables proteasome binding IDA
Inferred from Direct Assay
more info
 PubMed 
enables protein-macromolecule adaptor activity IMP
Inferred from Mutant Phenotype
more info
 PubMed 
Process Evidence Code Pubs
involved_in protein catabolic process IDA
Inferred from Direct Assay
more info
 PubMed 
involved_in protein catabolic process IMP
Inferred from Mutant Phenotype
more info
 PubMed 
involved_in ribosome biogenesis IEA
Inferred from Electronic Annotation
more info
  
Component Evidence Code Pubs
is_active_in nucleolus IBA
Inferred from Biological aspect of Ancestor
more info
  
located_in nucleolus IDA
Inferred from Direct Assay
more info
 PubMed 
located_in nucleolus IEA
Inferred from Electronic Annotation
more info
  
located_in nucleus IEA
Inferred from Electronic Annotation
more info
  
part_of preribosome, large subunit precursor HDA PubMed 
part_of preribosome, large subunit precursor IDA
Inferred from Direct Assay
more info
 PubMed 
part_of proteasome complex IEA
Inferred from Electronic Annotation
more info
  
part_of ribonucleoprotein complex IEA
Inferred from Electronic Annotation
more info
  

General protein information

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Preferred Names
Cic1p
NP_011919.1
  • Essential protein that interacts with proteasome components; has a potential role in proteasome substrate specificity; also copurifies with 66S pre-ribosomal particles

NCBI Reference Sequences (RefSeq)

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Genome Annotation

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference assembly

Genomic

  1. NC_001140.6 Reference assembly

    Range
    210848..211978
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. NM_001179182.1 → NP_011919.1  TPA: Cic1p [Saccharomyces cerevisiae S288C]

    See identical proteins and their annotated locations for NP_011919.1

    Status: REVIEWED

    UniProtKB/Swiss-Prot
    D3DL01, P38779
    UniProtKB/TrEMBL
    A6ZSW0, C7GT92, G2WFC6, N1P226
    Conserved Domains (1) summary
    pfam00687
    Location:77 → 287
    Ribosomal_L1; Ribosomal protein L1p/L10e family
Nucleotide Protein
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
P38779.1

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