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RPL27A [ Saccharomyces cerevisiae S288C ]

Gene ID: 856401, updated on 11-Sep-2024

Summary

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Official Symbol
RPL27A
Primary source
SGD:S000001052
Locus tag
YHR010W
See related
AllianceGenome:SGD:S000001052; FungiDB:YHR010W; VEuPathDB:YHR010W
Gene type
protein coding
RefSeq status
REVIEWED
Organism
Saccharomyces cerevisiae S288C (strain: S288C)
Lineage
Eukaryota; Fungi; Dikarya; Ascomycota; Saccharomycotina; Saccharomycetes; Saccharomycetales; Saccharomycetaceae; Saccharomyces
Also known as
RPL27
Summary
Predicted to be a structural constituent of ribosome. Predicted to be involved in cytoplasmic translation. Part of cytosolic large ribosomal subunit. Human ortholog(s) of this gene implicated in Diamond-Blackfan anemia 16. Orthologous to human RPL27 (ribosomal protein L27). [provided by Alliance of Genome Resources, Apr 2022]
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Genomic context

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Location:
chromosome: VIII
Exon count:
2
Sequence:
Chromosome: VIII; NC_001140.6 (126521..127492)

Chromosome VIII - NC_001140.6Genomic Context describing neighboring genes Neighboring gene superoxide dismutase SOD2 Neighboring gene Tda3p Neighboring gene putative serine--tRNA ligase DIA4 Neighboring gene retromer subunit VPS29

Genomic regions, transcripts, and products

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Genomic Sequence:
NC_001140.6

Go to nucleotide: Graphics FASTA GenBank

Bibliography

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Related articles in PubMed

  1. Pol5 is an essential ribosome biogenesis factor required for 60S ribosomal subunit maturation in Saccharomyces cerevisiae. Ramos-Sáenz A, et al. RNA, 2019 Nov. PMID 31413149, Free PMC Article
  2. Drug-induced phenotypes provide a tool for the functional analysis of yeast genes. Launhardt H, et al. Yeast, 1998 Jul. PMID 9717239
  3. Structural transitions during large ribosomal subunit maturation analyzed by tethered nuclease structure probing in S. cerevisiae. Pöll G, et al. PLoS One, 2017. PMID 28686620, Free PMC Article
  4. Respiratory metabolism and calorie restriction relieve persistent endoplasmic reticulum stress induced by calcium shortage in yeast. Busti S, et al. Sci Rep, 2016 Jun 16. PMID 27305947, Free PMC Article
  5. Stm1p, a G4 quadruplex and purine motif triplex nucleic acid-binding protein, interacts with ribosomes and subtelomeric Y' DNA in Saccharomyces cerevisiae. Van Dyke MW, et al. J Biol Chem, 2004 Jun 4. PMID 15044472

See all (97) citations in PubMed

GeneRIFs: Gene References Into Functions

Pathways from PubChem

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Interactions

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Products Interactant Other Gene Complex Source Pubs Description

General gene information

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Homology

Gene Ontology Provided by SGD

Function Evidence Code Pubs
enables structural constituent of ribosome IBA
Inferred from Biological aspect of Ancestor
more info
  
enables structural constituent of ribosome IC
Inferred by Curator
more info
 PubMed 
enables structural constituent of ribosome IEA
Inferred from Electronic Annotation
more info
  
Process Evidence Code Pubs
involved_in cytoplasmic translation IC
Inferred by Curator
more info
 PubMed 
involved_in translation IEA
Inferred from Electronic Annotation
more info
  
Component Evidence Code Pubs
located_in cytoplasm IEA
Inferred from Electronic Annotation
more info
  
part_of cytosolic large ribosomal subunit IBA
Inferred from Biological aspect of Ancestor
more info
  
part_of cytosolic large ribosomal subunit IDA
Inferred from Direct Assay
more info
 PubMed 
part_of ribonucleoprotein complex IEA
Inferred from Electronic Annotation
more info
  
located_in ribosome IEA
Inferred from Electronic Annotation
more info
  

General protein information

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Preferred Names
ribosomal 60S subunit protein L27A
NP_011874.1
  • Ribosomal 60S subunit protein L27A; homologous to mammalian ribosomal protein L27, no bacterial homolog; RPL27A has a paralog, RPL27B, that arose from the whole genome duplication

NCBI Reference Sequences (RefSeq)

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Genome Annotation

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference assembly

Genomic

  1. NC_001140.6 Reference assembly

    Range
    126521..127492
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. NM_001179140.1 → NP_011874.1  TPA: ribosomal 60S subunit protein L27A [Saccharomyces cerevisiae S288C]

    See identical proteins and their annotated locations for NP_011874.1

    Status: REVIEWED

    UniProtKB/Swiss-Prot
    D3DKV5, P0C2H6, P38706
    UniProtKB/TrEMBL
    A6ZSR4, B3LFJ4, C7GMQ1, C8Z630, G2WF78, N1PAK8
    Conserved Domains (1) summary
    cl00354
    Location:1 → 136
    KOW; an acronym for the authors' surnames (Kyrpides, Ouzounis and Woese)
Nucleotide Protein
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
P0C2H6.1

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