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THOC5 THO complex subunit 5 [ Homo sapiens (human) ]

Gene ID: 8563, updated on 11-Apr-2024

Summary

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Official Symbol
THOC5provided by HGNC
Official Full Name
THO complex subunit 5provided by HGNC
Primary source
HGNC:HGNC:19074
See related
Ensembl:ENSG00000100296 MIM:612733; AllianceGenome:HGNC:19074
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Homo sapiens
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
Also known as
Fmip; PK1.3; fSAP79; C22orf19
Summary
Predicted to enable mRNA binding activity. Involved in several processes, including monocyte differentiation; negative regulation of DNA damage checkpoint; and viral mRNA export from host cell nucleus. Located in nucleoplasm. Part of THO complex part of transcription export complex. Colocalizes with chromosome, telomeric region. Implicated in breast carcinoma. [provided by Alliance of Genome Resources, Apr 2022]
Expression
Ubiquitous expression in testis (RPKM 10.3), endometrium (RPKM 6.9) and 25 other tissues See more
Orthologs
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Genomic context

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Location:
22q12.2
Exon count:
24
Annotation release Status Assembly Chr Location
RS_2023_10 current GRCh38.p14 (GCF_000001405.40) 22 NC_000022.11 (29505879..29553757, complement)
RS_2023_10 current T2T-CHM13v2.0 (GCF_009914755.1) 22 NC_060946.1 (29969253..30017117, complement)
105.20220307 previous assembly GRCh37.p13 (GCF_000001405.25) 22 NC_000022.10 (29901868..29949746, complement)

Chromosome 22 - NC_000022.11Genomic Context describing neighboring genes Neighboring gene uncharacterized LOC107985541 Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr22:29856012-29856563 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr22:29859341-29859868 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr22:29859869-29860396 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr22:29866133-29866633 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr22:29874167-29874668 Neighboring gene NANOG-H3K27ac-H3K4me1 hESC enhancer GRCh37_chr22:29877229-29878083 Neighboring gene neurofilament heavy chain Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr22:29947869-29948568 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 13592 Neighboring gene H3K27ac hESC enhancer GRCh37_chr22:29949966-29950663 Neighboring gene nipsnap homolog 1 Neighboring gene Sharpr-MPRA regulatory region 2653 Neighboring gene Sharpr-MPRA regulatory region 10387 Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr22:29976263-29976875 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 13593 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 13594 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 18817 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 13595 Neighboring gene NANOG-H3K27ac hESC enhancer GRCh37_chr22:30002345-30002866 Neighboring gene ribulose-5-phosphate-3-epimerase pseudogene 4 Neighboring gene NF2, moesin-ezrin-radixin like (MERLIN) tumor suppressor

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Expression

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  • Project title: HPA RNA-seq normal tissues
  • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
  • BioProject: PRJEB4337
  • Publication: PMID 24309898
  • Analysis date: Wed Apr 4 07:08:55 2018

Bibliography

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Related articles in PubMed

  1. THOC5 regulates human osteoclastogenesis. Mun SH, et al. Eur J Cell Biol, 2022 Jun-Aug. PMID 35688054
  2. Polymorphism of the THOC5 of the transcription/export multiprotein complex and its correlation with the lipid and metabolic profile in middle-aged women. Loja-Chango R, et al. Gynecol Endocrinol, 2020 Mar. PMID 31402763
  3. Human THO coordinates transcription termination and subsequent transcript release from the HSP70 locus. Katahira J, et al. Genes Cells, 2019 Apr. PMID 30721563
  4. Depletion of three combined THOC5 mRNA export protein target genes synergistically induces human hepatocellular carcinoma cell death. Saran S, et al. Oncogene, 2016 Jul 21. PMID 26549021
  5. Human TREX component Thoc5 affects alternative polyadenylation site choice by recruiting mammalian cleavage factor I. Katahira J, et al. Nucleic Acids Res, 2013 Aug. PMID 23685434, Free PMC Article

See all (85) citations in PubMed

GeneRIFs: Gene References Into Functions

What's a GeneRIF?
  1. THOC5 regulates human osteoclastogenesis.
    Title: THOC5 regulates human osteoclastogenesis.
  2. RNA editing enzyme APOBEC3A promotes pro-inflammatory M1 macrophage polarization.
    Title: RNA editing enzyme APOBEC3A promotes pro-inflammatory M1 macrophage polarization.
  3. Polymorphism of the THOC5 of the transcription/export multiprotein complex and its correlation with the lipid and metabolic profile in middle-aged women.
    Title: Polymorphism of the THOC5 of the transcription/export multiprotein complex and its correlation with the lipid and metabolic profile in middle-aged women.
  4. Human THO maintains the stability of repetitive DNA.
    Title: Human THO maintains the stability of repetitive DNA.
  5. THOC5 regulates transcription termination and subsequent transcript release from the HSPA1A locus.
    Title: Human THO coordinates transcription termination and subsequent transcript release from the HSP70 locus.
  6. Data suggest that the suppression of the multiple THOC5 target genes may represent a novel strategy for hepatocellular carcinoma (HCC) therapy.
    Title: Depletion of three combined THOC5 mRNA export protein target genes synergistically induces human hepatocellular carcinoma cell death.
  7. THOC5 to be a novel gene involved in the regulation of serum HDL-C levels
    Title: THOC5: a novel gene involved in HDL-cholesterol metabolism.
  8. Authors suggest a model in which human Thoc5 controls polyadenylation site choice through the co-transcriptional loading of CFIm68 onto target genes.
    Title: Human TREX component Thoc5 affects alternative polyadenylation site choice by recruiting mammalian cleavage factor I.
  9. show that THOC5 Y225 phosphorylation governs mRNA binding. In addition, CXCL12 is shown to induce THOC5 Y225 phosphorylation, and site-directed mutagenesis demonstrates that this modulates motile response
    Title: A pathway from leukemogenic oncogenes and stem cell chemokines to RNA processing via THOC5.
  10. show here that DNA damage drastically decreased the cytoplasmic pool of a set of THOC5-dependent mRNAs and impaired the THOC5/mRNA complex formation
    Title: An ataxia-telangiectasia-mutated (ATM) kinase mediated response to DNA damage down-regulates the mRNA-binding potential of THOC5.
Submit: New GeneRIF Correction See all GeneRIFs (13)

Phenotypes

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Find tests for this gene in the NIH Genetic Testing Registry (GTR)

Review eQTL and phenotype association data in this region using PheGenI

EBI GWAS Catalog

Description
A genome-wide association study of carotid atherosclerosis in HIV-infected men.
EBI GWAS Catalog
THOC5: a novel gene involved in HDL-cholesterol metabolism.
EBI GWAS Catalog

Variation

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See variants in ClinVar

See studies and variants in dbVar

See Variation Viewer (GRCh37.p13)

See Variation Viewer (GRCh38)

Genotypes

Pathways from PubChem

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Interactions

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Products Interactant Other Gene Complex Source Pubs Description

General gene information

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Markers

Homology

Gene Ontology Provided by GOA

Function Evidence Code Pubs
enables mRNA binding IBA
Inferred from Biological aspect of Ancestor
more info
  
enables protein binding IPI
Inferred from Physical Interaction
more info
 PubMed 
Process Evidence Code Pubs
involved_in RNA splicing IEA
Inferred from Electronic Annotation
more info
  
involved_in mRNA export from nucleus IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in mRNA export from nucleus IDA
Inferred from Direct Assay
more info
 PubMed 
involved_in mRNA export from nucleus IMP
Inferred from Mutant Phenotype
more info
 PubMed 
involved_in mRNA processing IEA
Inferred from Electronic Annotation
more info
  
involved_in monocyte differentiation IDA
Inferred from Direct Assay
more info
 PubMed 
involved_in primitive hemopoiesis ISS
Inferred from Sequence or Structural Similarity
more info
  
Component Evidence Code Pubs
part_of THO complex IDA
Inferred from Direct Assay
more info
 PubMed 
part_of THO complex part of transcription export complex IBA
Inferred from Biological aspect of Ancestor
more info
  
part_of THO complex part of transcription export complex IDA
Inferred from Direct Assay
more info
 PubMed 
colocalizes_with chromosome, telomeric region IDA
Inferred from Direct Assay
more info
 PubMed 
located_in cytoplasm IEA
Inferred from Electronic Annotation
more info
  
located_in nucleoplasm IDA
Inferred from Direct Assay
more info
  
located_in nucleoplasm TAS
Traceable Author Statement
more info
  
located_in nucleus IDA
Inferred from Direct Assay
more info
 PubMed 
part_of transcription export complex IDA
Inferred from Direct Assay
more info
 PubMed 

General protein information

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Preferred Names
THO complex subunit 5 homolog
Names
Fms-interacting protein
NF2/meningioma region protein pK1.3
PP39.2
THO complex 5
functional spliceosome-associated protein 79
hTREX90
placental protein 39.2

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001002877.2 → NP_001002877.1  THO complex subunit 5 homolog

    See identical proteins and their annotated locations for NP_001002877.1

    Status: VALIDATED

    Description
    Transcript Variant: This variant (3) differs in the 5' UTR compared to variant 1. All four variants encode the same protein.
    Source sequence(s)
    AB023200, AC005529, BQ184247, BX381026, BX400943, BX404329, CR456542
    Consensus CDS
    CCDS13859.1
    UniProtKB/Swiss-Prot
    O60839, Q13769, Q9UPZ5
    Related
    ENSP00000380971.2, ENST00000397873.6
    Conserved Domains (1) summary
    pfam09766
    Location:97 → 452
    FimP; Fms-interacting protein

  2. NM_001002878.1 → NP_001002878.1  THO complex subunit 5 homolog

    See identical proteins and their annotated locations for NP_001002878.1

    Status: VALIDATED

    Description
    Transcript Variant: This variant (1) represents the longest transcript. All four variants encode the same protein.
    Source sequence(s)
    AB023200, BQ184247, BX400943, BX404329, CN387648, CR456542
    Consensus CDS
    CCDS13859.1
    UniProtKB/Swiss-Prot
    O60839, Q13769, Q9UPZ5
    Related
    ENSP00000380970.1, ENST00000397872.5
    Conserved Domains (1) summary
    pfam09766
    Location:97 → 452
    FimP; Fms-interacting protein

  3. NM_001002879.1 → NP_001002879.1  THO complex subunit 5 homolog

    See identical proteins and their annotated locations for NP_001002879.1

    Status: VALIDATED

    Description
    Transcript Variant: This variant (2) differs in the 5' UTR compared to variant 1. All four variants encode the same protein.
    Source sequence(s)
    AB023200, BQ184247, BU187531, BX400943, BX404329, CR456542
    Consensus CDS
    CCDS13859.1
    UniProtKB/Swiss-Prot
    O60839, Q13769, Q9UPZ5
    Related
    ENSP00000380969.1, ENST00000397871.5
    Conserved Domains (1) summary
    pfam09766
    Location:97 → 452
    FimP; Fms-interacting protein

  4. NM_003678.5 → NP_003669.4  THO complex subunit 5 homolog

    See identical proteins and their annotated locations for NP_003669.4

    Status: VALIDATED

    Description
    Transcript Variant: This variant (4) differs in the 5' UTR compared to variant 1. All four variants encode the same protein.
    Source sequence(s)
    AB023200, AC005529, BQ184247, BX400943, BX404329, CR456542
    Consensus CDS
    CCDS13859.1
    UniProtKB/Swiss-Prot
    O60839, Q13769, Q9UPZ5
    Related
    ENSP00000420306.1, ENST00000490103.6
    Conserved Domains (1) summary
    pfam09766
    Location:97 → 452
    FimP; Fms-interacting protein

RefSeqs of Annotated Genomes: GCF_000001405.40-RS_2023_10

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCh38.p14 Primary Assembly

Genomic

  1. NC_000022.11 Reference GRCh38.p14 Primary Assembly

    Range
    29505879..29553757 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_005261797.2 → XP_005261854.1  THO complex subunit 5 homolog isoform X1

    See identical proteins and their annotated locations for XP_005261854.1

    Conserved Domains (1) summary
    pfam09766
    Location:97 → 463
    FimP; Fms-interacting protein

  2. XM_005261798.2 → XP_005261855.1  THO complex subunit 5 homolog isoform X1

    See identical proteins and their annotated locations for XP_005261855.1

    Conserved Domains (1) summary
    pfam09766
    Location:97 → 463
    FimP; Fms-interacting protein

  3. XM_005261799.2 → XP_005261856.1  THO complex subunit 5 homolog isoform X1

    See identical proteins and their annotated locations for XP_005261856.1

    Conserved Domains (1) summary
    pfam09766
    Location:97 → 463
    FimP; Fms-interacting protein

  4. XM_047441559.1 → XP_047297515.1  THO complex subunit 5 homolog isoform X2

    UniProtKB/Swiss-Prot
    O60839, Q13769, Q9UPZ5

  5. XM_047441558.1 → XP_047297514.1  THO complex subunit 5 homolog isoform X1

  6. XM_006724347.2 → XP_006724410.1  THO complex subunit 5 homolog isoform X1

    See identical proteins and their annotated locations for XP_006724410.1

    Conserved Domains (1) summary
    pfam09766
    Location:97 → 463
    FimP; Fms-interacting protein

  7. XM_005261801.5 → XP_005261858.1  THO complex subunit 5 homolog isoform X3

    Conserved Domains (1) summary
    pfam09766
    Location:1 → 113
    FimP; Fms-interacting protein

Alternate T2T-CHM13v2.0

Genomic

  1. NC_060946.1 Alternate T2T-CHM13v2.0

    Range
    29969253..30017117 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_054326071.1 → XP_054182046.1  THO complex subunit 5 homolog isoform X1

  2. XM_054326070.1 → XP_054182045.1  THO complex subunit 5 homolog isoform X1

  3. XM_054326073.1 → XP_054182048.1  THO complex subunit 5 homolog isoform X1

  4. XM_054326075.1 → XP_054182050.1  THO complex subunit 5 homolog isoform X2

    UniProtKB/Swiss-Prot
    O60839, Q13769, Q9UPZ5

  5. XM_054326074.1 → XP_054182049.1  THO complex subunit 5 homolog isoform X1

  6. XM_054326072.1 → XP_054182047.1  THO complex subunit 5 homolog isoform X1

  7. XM_054326076.1 → XP_054182051.1  THO complex subunit 5 homolog isoform X3

Nucleotide Protein
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
Q13769.2 GenPept UniProtKB/Swiss-Prot:Q13769

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