U.S. flag

An official website of the United States government

Format

Send to:

Choose Destination

LEC1 [ Saccharomyces cerevisiae S288C ]

Gene ID: 856212, updated on 11-Sep-2024

Summary

Go to the top of the page Help
Official Symbol
LEC1
Primary source
SGD:S000006301
Locus tag
YPR097W
See related
AllianceGenome:SGD:S000006301; FungiDB:YPR097W; VEuPathDB:YPR097W
Gene type
protein coding
RefSeq status
REVIEWED
Organism
Saccharomyces cerevisiae S288C (strain: S288C)
Lineage
Eukaryota; Fungi; Dikarya; Ascomycota; Saccharomycotina; Saccharomycetes; Saccharomycetales; Saccharomycetaceae; Saccharomyces
Summary
Enables phosphatidylinositol binding activity. Located in mitochondrion. [provided by Alliance of Genome Resources, Apr 2022]
NEW
Try the new Gene table
Try the new Transcript table

Genomic context

Go to the top of the page Help
Location:
chromosome: XVI
Exon count:
1
Sequence:
Chromosome: XVI; NC_001148.4 (725394..728615)

Chromosome XVI - NC_001148.4Genomic Context describing neighboring genes Neighboring gene Arf family guanine nucleotide exchange factor SYT1 Neighboring gene uncharacterized protein Neighboring gene Tmh18p Neighboring gene uncharacterized protein Neighboring gene mitochondrial 54S ribosomal protein MRPL51

Genomic regions, transcripts, and products

Go to the top of the page Help
Genomic Sequence:
NC_001148.4

Go to nucleotide: Graphics FASTA GenBank

Bibliography

Go to the top of the pageHelp

Related articles in PubMed

  1. All phox homology (PX) domains from Saccharomyces cerevisiae specifically recognize phosphatidylinositol 3-phosphate. Yu JW, et al. J Biol Chem, 2001 Nov 23. PMID 11557775
  2. The phosphoinositide 3-kinase Vps34p is required for pexophagy in Saccharomyces cerevisiae. Grunau S, et al. Biochem J, 2011 Feb 15. PMID 21121900
  3. Loss of Cardiolipin Leads to Perturbation of Acetyl-CoA Synthesis. Raja V, et al. J Biol Chem, 2017 Jan 20. PMID 27941023, Free PMC Article
  4. Effect of Sec61 interaction with Mpd1 on endoplasmic reticulum-associated degradation. Pereira F, et al. PLoS One, 2019. PMID 30682149, Free PMC Article
  5. Bayesian modeling of the yeast SH3 domain interactome predicts spatiotemporal dynamics of endocytosis proteins. Tonikian R, et al. PLoS Biol, 2009 Oct. PMID 19841731, Free PMC Article

See all (22) citations in PubMed

GeneRIFs: Gene References Into Functions

Interactions

Go to the top of the page Help
Products Interactant Other Gene Complex Source Pubs Description

General gene information

Go to the top of the page Help

Homology

Gene Ontology Provided by SGD

Function Evidence Code Pubs
enables phosphatidylinositol binding IBA
Inferred from Biological aspect of Ancestor
more info
  
enables phosphatidylinositol binding IDA
Inferred from Direct Assay
more info
 PubMed 
enables phosphatidylinositol binding IEA
Inferred from Electronic Annotation
more info
  
Process Evidence Code Pubs
involved_in biological_process ND
No biological Data available
more info
  
Component Evidence Code Pubs
located_in membrane IEA
Inferred from Electronic Annotation
more info
  
located_in mitochondrial membrane IEA
Inferred from Electronic Annotation
more info
  
located_in mitochondrion HDA PubMed 
located_in mitochondrion IEA
Inferred from Electronic Annotation
more info
  

General protein information

Go to the top of the page Help
Preferred Names
Lec1p
NP_015422.2
  • Phosphoinositide-binding regulator of ergosterol distribution; contains PX (Phox homology) domain; associated with ER-lipid droplet contact site; may facilitate ergosterol transport between plasma membrane and lipid droplets

NCBI Reference Sequences (RefSeq)

Go to the top of the page Help

NEW Try the new Transcript table

Genome Annotation

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference assembly

Genomic

  1. NC_001148.4 Reference assembly

    Range
    725394..728615
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. NM_001184194.2 → NP_015422.2  TPA: Lec1p [Saccharomyces cerevisiae S288C]

    See identical proteins and their annotated locations for NP_015422.2

    Status: REVIEWED

    UniProtKB/Swiss-Prot
    D6W496, Q06839
    UniProtKB/TrEMBL
    C8ZJB9, N1P295
    Conserved Domains (3) summary
    cd06869
    Location:201 → 502
    PX_UP2_fungi; The phosphoinositide binding Phox Homology domain of uncharacterized fungal proteins
    pfam12825
    Location:567 → 917
    DUF3818; Domain of unknown function in PX-proteins (DUF3818)
    pfam12828
    Location:6 → 149
    PXB; PX-associated
Nucleotide Protein
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
Q06839.2

Gene LinkOut

The following LinkOut resources are supplied by external providers. These providers are responsible for maintaining the links.

Other Literature Sources
Molecular Biology Databases
Research Materials
Tools