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LSP1 lipid-binding protein LSP1 [ Saccharomyces cerevisiae S288C ]

Gene ID: 856103, updated on 18-Sep-2024

Summary

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Official Symbol
LSP1
Official Full Name
lipid-binding protein LSP1
Primary source
SGD:S000005925
Locus tag
YPL004C
See related
AllianceGenome:SGD:S000005925; FungiDB:YPL004C; VEuPathDB:YPL004C
Gene type
protein coding
RefSeq status
REVIEWED
Organism
Saccharomyces cerevisiae S288C (strain: S288C)
Lineage
Eukaryota; Fungi; Dikarya; Ascomycota; Saccharomycotina; Saccharomycetes; Saccharomycetales; Saccharomycetaceae; Saccharomyces
Summary
Enables lipid binding activity. Involved in endocytosis; negative regulation of protein kinase activity; and response to heat. Located in eisosome. [provided by Alliance of Genome Resources, Apr 2022]
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Genomic context

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See LSP1 in Genome Data Viewer
Location:
chromosome: XVI
Exon count:
1
Sequence:
Chromosome: XVI; NC_001148.4 (550632..551657, complement)

Chromosome XVI - NC_001148.4Genomic Context describing neighboring genes Neighboring gene sphingolipid transporter Neighboring gene Aep3p Neighboring gene Ula1p Neighboring gene ESCRT-II subunit protein SNF8

Genomic regions, transcripts, and products

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Genomic Sequence:
NC_001148.4

Go to nucleotide: Graphics FASTA GenBank

Bibliography

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Related articles in PubMed

  1. Lsp1 partially substitutes for Pil1 function in eisosome assembly under stress conditions. Vesela P, et al. J Cell Sci, 2023 Feb 1. PMID 36601791
  2. Eisosomes are dynamic plasma membrane domains showing pil1-lsp1 heteroligomer binding equilibrium. Olivera-Couto A, et al. Biophys J, 2015 Apr 7. PMID 25863055, Free PMC Article
  3. Eisosome proteins assemble into a membrane scaffold. Karotki L, et al. J Cell Biol, 2011 Nov 28. PMID 22123866, Free PMC Article
  4. Eisosome-driven plasma membrane organization is mediated by BAR domains. Ziółkowska NE, et al. Nat Struct Mol Biol, 2011 Jun 19. PMID 21685922
  5. Phosphoproteomic analysis of protein kinase C signaling in Saccharomyces cerevisiae reveals Slt2 mitogen-activated protein kinase (MAPK)-dependent phosphorylation of eisosome core components. Mascaraque V, et al. Mol Cell Proteomics, 2013 Mar. PMID 23221999, Free PMC Article

See all (98) citations in PubMed

GeneRIFs: Gene References Into Functions

What's a GeneRIF?
  1. Lsp1 partially substitutes for Pil1 function in eisosome assembly under stress conditions.
    Title: Lsp1 partially substitutes for Pil1 function in eisosome assembly under stress conditions.
  2. This probably is the first report showing that the transcription factor Bdf1p regulates endocytosis under salt stress via LSP1, a major component of eisosomes that regulate the sites of endocytosis.
    Title: The yeast BDF1 regulates endocytosis via LSP1 under salt stress.
  3. Data indicate that Pkc1-induced phosphorylation of the eisosome core components Pil1 and Lsp1 was not exerted directly by Pkc1, but involved signaling through the Slt2 MAPK module.
    Title: Phosphoproteomic analysis of protein kinase C signaling in Saccharomyces cerevisiae reveals Slt2 mitogen-activated protein kinase (MAPK)-dependent phosphorylation of eisosome core components.
  4. Seg1/Sle1 controls eisosome assembly and shape, which also involves Pil1 and Lsp1
    Title: Seg1 controls eisosome assembly and shape.
  5. Pil1 and Lsp1 self-assemble into higher-order structures and bind preferentially to phosphoinositide-containing membranes.
    Title: Eisosome proteins assemble into a membrane scaffold.
  6. large immobile protein assemblies at the plasma membrane in the yeast Saccharomyces cerevisiae that mark endocytic sites, termed eisosomes, are composed primarily of two cytoplasmic proteins, Pil1 and Lsp1
    Title: Eisosomes mark static sites of endocytosis.
Submit: New GeneRIF Correction

Interactions

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Products Interactant Other Gene Complex Source Pubs Description

General gene information

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Homology

Gene Ontology Provided by SGD

Function Evidence Code Pubs
enables lipid binding IBA
Inferred from Biological aspect of Ancestor
more info
  
enables lipid binding IDA
Inferred from Direct Assay
more info
 PubMed 
Process Evidence Code Pubs
involved_in eisosome assembly IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in eisosome assembly IMP
Inferred from Mutant Phenotype
more info
 PubMed 
involved_in endocytosis IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in endocytosis IMP
Inferred from Mutant Phenotype
more info
 PubMed 
acts_upstream_of_or_within membrane organization IMP
Inferred from Mutant Phenotype
more info
 PubMed 
involved_in response to heat IMP
Inferred from Mutant Phenotype
more info
 PubMed 
Component Evidence Code Pubs
located_in cell cortex IEA
Inferred from Electronic Annotation
more info
  
located_in cell periphery HDA PubMed 
located_in cytoplasm HDA PubMed 
located_in cytoplasm IEA
Inferred from Electronic Annotation
more info
  
located_in eisosome IDA
Inferred from Direct Assay
more info
 PubMed 
part_of eisosome filament IBA
Inferred from Biological aspect of Ancestor
more info
  
located_in mitochondrial outer membrane HDA PubMed 
located_in mitochondrion HDA PubMed 
located_in plasma membrane HDA PubMed 
is_active_in plasma membrane IBA
Inferred from Biological aspect of Ancestor
more info
  

General protein information

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Preferred Names
lipid-binding protein LSP1
NP_015321.1
  • Eisosome core component; eisosomes are large immobile patch structures at the cell cortex associated with endocytosis; phosphorylated on Thr233 upon Pkc1p hyperactivation in a Slt2p MAPK-dependent fashion; null mutants show activation of Pkc1p/Ypk1p stress resistance pathways; member of the BAR domain family

NCBI Reference Sequences (RefSeq)

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Genome Annotation

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference assembly

Genomic

  1. NC_001148.4 Reference assembly

    Range
    550632..551657 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. NM_001183818.1 → NP_015321.1  TPA: lipid-binding protein LSP1 [Saccharomyces cerevisiae S288C]

    See identical proteins and their annotated locations for NP_015321.1

    Status: REVIEWED

    UniProtKB/Swiss-Prot
    D6W408, Q12230
    UniProtKB/TrEMBL
    A6ZWP2, B3LL58, B5VTF7, C7GV48, C8ZJ22, N1P1W7
    Conserved Domains (1) summary
    pfam13805
    Location:1 → 264
    Pil1; Eisosome component PIL1
Nucleotide Protein
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
Q12230.1

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