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ALD6 aldehyde dehydrogenase (NADP(+)) ALD6 [ Saccharomyces cerevisiae S288C ]

Gene ID: 856044, updated on 3-Nov-2024

Summary

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Official Symbol
ALD6
Official Full Name
aldehyde dehydrogenase (NADP(+)) ALD6
Primary source
SGD:S000005982
Locus tag
YPL061W
See related
AllianceGenome:SGD:S000005982; FungiDB:YPL061W; VEuPathDB:YPL061W
Gene type
protein coding
RefSeq status
REVIEWED
Organism
Saccharomyces cerevisiae S288C (strain: S288C)
Lineage
Eukaryota; Fungi; Dikarya; Ascomycota; Saccharomycotina; Saccharomycetes; Saccharomycetales; Saccharomycetaceae; Saccharomyces
Also known as
ALD1
Summary
Enables aldehyde dehydrogenase [NAD(P)+] activity. Involved in NADPH regeneration; acetate biosynthetic process; and response to salt stress. Located in cytosol and mitochondrion. Human ortholog(s) of this gene implicated in several diseases, including alcohol dependence; alcohol use disorder; artery disease (multiple); diabetes mellitus (multiple); and liver disease (multiple). Orthologous to several human genes including ALDH1A1 (aldehyde dehydrogenase 1 family member A1); ALDH1A2 (aldehyde dehydrogenase 1 family member A2); and ALDH1A3 (aldehyde dehydrogenase 1 family member A3). [provided by Alliance of Genome Resources, Nov 2024]
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Genomic context

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See ALD6 in Genome Data Viewer
Location:
chromosome: XVI
Exon count:
1
Sequence:
Chromosome: XVI; NC_001148.4 (432588..434090)

Chromosome XVI - NC_001148.4Genomic Context describing neighboring genes Neighboring gene protein translocase subunit TIM50 Neighboring gene uncharacterized protein Neighboring gene Mfm1p Neighboring gene tRNA-Cys

Genomic regions, transcripts, and products

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Genomic Sequence:
NC_001148.4

Go to nucleotide: Graphics FASTA GenBank

Bibliography

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Related articles in PubMed

  1. Expression of aldehyde dehydrogenase 6 reduces inhibitory effect of furan derivatives on cell growth and ethanol production in Saccharomyces cerevisiae. Park SE, et al. Bioresour Technol, 2011 May. PMID 21421300
  2. The ALD6 gene of Saccharomyces cerevisiae encodes a cytosolic, Mg(2+)-activated acetaldehyde dehydrogenase. Meaden PG, et al. Yeast, 1997 Nov. PMID 9392076
  3. Identification of Ald6p as the target of a class of small-molecule suppressors of FK506 and their use in network dissection. Butcher RA, et al. Proc Natl Acad Sci U S A, 2004 May 25. PMID 15146068, Free PMC Article
  4. Formaldehyde Treatment Using Overexpressed Aldehyde Dehydrogenase 6 from Recombinant Saccharomyces cerevisiae. Lee S, et al. J Nanosci Nanotechnol, 2018 Apr 1. PMID 29442983
  5. Rewiring Central Carbon Metabolism Ensures Increased Provision of Acetyl-CoA and NADPH Required for 3-OH-Propionic Acid Production. Qin N, et al. ACS Synth Biol, 2020 Dec 18. PMID 33186034

See all (141) citations in PubMed

GeneRIFs: Gene References Into Functions

What's a GeneRIF?
  1. Mitochondrial NAD dependent aldehyde dehydrogenase either from yeast or human replaces yeast cytoplasmic NADP dependent aldehyde dehydrogenase for the aerobic growth of yeast on ethanol.
    Title: Mitochondrial NAD dependent aldehyde dehydrogenase either from yeast or human replaces yeast cytoplasmic NADP dependent aldehyde dehydrogenase for the aerobic growth of yeast on ethanol.
  2. Ald6p enzymatic activity may be disadvantageous for survival under nitrogen starvation; therefore, yeast cells may preferentially eliminate Ald6p via autophagy
    Title: Ald6p is a preferred target for autophagy in yeast, Saccharomyces cerevisiae.
Submit: New GeneRIF Correction

Pathways from PubChem

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Interactions

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Products Interactant Other Gene Complex Source Pubs Description

General gene information

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Homology

Gene Ontology Provided by SGD

Function Evidence Code Pubs
enables aldehyde dehydrogenase (NAD+) activity IBA
Inferred from Biological aspect of Ancestor
more info
  
enables aldehyde dehydrogenase (NADP+) activity IEA
Inferred from Electronic Annotation
more info
  
enables aldehyde dehydrogenase [NAD(P)+] activity IDA
Inferred from Direct Assay
more info
 PubMed 
enables aldehyde dehydrogenase [NAD(P)+] activity IMP
Inferred from Mutant Phenotype
more info
 PubMed 
enables oxidoreductase activity IEA
Inferred from Electronic Annotation
more info
  
enables oxidoreductase activity, acting on the aldehyde or oxo group of donors, NAD or NADP as acceptor IEA
Inferred from Electronic Annotation
more info
  
Process Evidence Code Pubs
involved_in NADPH regeneration IGI
Inferred from Genetic Interaction
more info
 PubMed 
involved_in acetate biosynthetic process IMP
Inferred from Mutant Phenotype
more info
 PubMed 
involved_in ethanol catabolic process IEA
Inferred from Electronic Annotation
more info
  
involved_in response to salt stress IMP
Inferred from Mutant Phenotype
more info
 PubMed 
Component Evidence Code Pubs
located_in cytoplasm IEA
Inferred from Electronic Annotation
more info
  
located_in cytosol IDA
Inferred from Direct Assay
more info
 PubMed 
located_in cytosol IMP
Inferred from Mutant Phenotype
more info
 PubMed 
located_in mitochondrion HDA PubMed 
located_in mitochondrion IDA
Inferred from Direct Assay
more info
 PubMed 

General protein information

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Preferred Names
aldehyde dehydrogenase (NADP(+)) ALD6
NP_015264.1
  • Cytosolic aldehyde dehydrogenase; activated by Mg2+ and utilizes NADP+ as the preferred coenzyme; required for conversion of acetaldehyde to acetate; constitutively expressed; localizes to the mitochondrial outer surface upon oxidative stress; negative regulator of nonselective autophagy; Stb5p directly regulates the expression of ALD6 mRNA and directly binds to the ALD6 promoter

NCBI Reference Sequences (RefSeq)

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Genome Annotation

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference assembly

Genomic

  1. NC_001148.4 Reference assembly

    Range
    432588..434090
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. NM_001183875.1 → NP_015264.1  TPA: aldehyde dehydrogenase (NADP(+)) ALD6 [Saccharomyces cerevisiae S288C]

    See identical proteins and their annotated locations for NP_015264.1

    Status: REVIEWED

    UniProtKB/Swiss-Prot
    D6W3V3, P54115, Q02782
    UniProtKB/TrEMBL
    A6ZWI7, B3LL07, C7GTZ5, C8ZIW9, E9P9H2, G2WPB8, N1NX93
    Conserved Domains (1) summary
    cd07091
    Location:23 → 498
    ALDH_F1-2_Ald2-like; ALDH subfamily: ALDH families 1and 2, including 10-formyltetrahydrofolate dehydrogenase, NAD+-dependent retinal dehydrogenase 1 and related proteins
Nucleotide Protein
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
P54115.4

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