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FMP30 N-acetylphosphatidylethanolamine-hydrolyzing phospholipase D [ Saccharomyces cerevisiae S288C ]

Gene ID: 856001, updated on 28-Oct-2024

Summary

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Official Symbol
FMP30
Official Full Name
N-acetylphosphatidylethanolamine-hydrolyzing phospholipase D
Primary source
SGD:S000006024
Locus tag
YPL103C
See related
AllianceGenome:SGD:S000006024; FungiDB:YPL103C; VEuPathDB:YPL103C
Gene type
protein coding
RefSeq status
REVIEWED
Organism
Saccharomyces cerevisiae S288C (strain: S288C)
Lineage
Eukaryota; Fungi; Dikarya; Ascomycota; Saccharomycotina; Saccharomycetes; Saccharomycetales; Saccharomycetaceae; Saccharomyces
Summary
Predicted to enable N-acylphosphatidylethanolamine-specific phospholipase D activity. Involved in N-acylethanolamine metabolic process and N-acylphosphatidylethanolamine metabolic process. Located in mitochondrial inner membrane. Orthologous to human NAPEPLD (N-acyl phosphatidylethanolamine phospholipase D). [provided by Alliance of Genome Resources, Oct 2024]
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Genomic context

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See FMP30 in Genome Data Viewer
Location:
chromosome: XVI
Exon count:
1
Sequence:
Chromosome: XVI; NC_001148.4 (358000..359406, complement)

Chromosome XVI - NC_001148.4Genomic Context describing neighboring genes Neighboring gene Syh1p Neighboring gene aspartate--tRNA ligase MSD1 Neighboring gene Elongator subunit ELP4 Neighboring gene Atg21p

Genomic regions, transcripts, and products

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Genomic Sequence:
NC_001148.4

Go to nucleotide: Graphics FASTA GenBank

Bibliography

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Related articles in PubMed

  1. Presence and potential signaling function of N-acylethanolamines and their phospholipid precursors in the yeast Saccharomyces cerevisiae. Merkel O, et al. Biochim Biophys Acta, 2005 Jun 1. PMID 15878693
  2. Interaction of MDM33 with mitochondrial inner membrane homeostasis pathways in yeast. Klecker T, et al. Sci Rep, 2015 Dec 16. PMID 26669658, Free PMC Article
  3. Cooperative function of Fmp30, Mdm31, and Mdm32 in Ups1-independent cardiolipin accumulation in the yeast Saccharomyces cerevisiae. Miyata N, et al. Sci Rep, 2017 Nov 27. PMID 29180659, Free PMC Article
  4. Evolutionary origins of the endocannabinoid system. McPartland JM, et al. Gene, 2006 Mar 29. PMID 16434153
  5. FMP30 is required for the maintenance of a normal cardiolipin level and mitochondrial morphology in the absence of mitochondrial phosphatidylethanolamine synthesis. Kuroda T, et al. Mol Microbiol, 2011 Apr. PMID 21306442

See all (35) citations in PubMed

GeneRIFs: Gene References Into Functions

What's a GeneRIF?
  1. Results indicated that Fmp30p is involved in the maintenance of mitochondrial morphology and required for the accumulation of a normal level of CL in the absence of mitochondrial phosphatidylethanolamine synthesis.
    Title: FMP30 is required for the maintenance of a normal cardiolipin level and mitochondrial morphology in the absence of mitochondrial phosphatidylethanolamine synthesis.
Submit: New GeneRIF Correction

Interactions

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Products Interactant Other Gene Complex Source Pubs Description

General gene information

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Homology

Gene Ontology Provided by SGD

Function Evidence Code Pubs
enables N-acylphosphatidylethanolamine-specific phospholipase D activity IBA
Inferred from Biological aspect of Ancestor
more info
  
enables N-acylphosphatidylethanolamine-specific phospholipase D activity IEA
Inferred from Electronic Annotation
more info
  
enables N-acylphosphatidylethanolamine-specific phospholipase D activity ISS
Inferred from Sequence or Structural Similarity
more info
 PubMed 
enables hydrolase activity IEA
Inferred from Electronic Annotation
more info
  
enables metal ion binding IEA
Inferred from Electronic Annotation
more info
  
enables zinc ion binding IEA
Inferred from Electronic Annotation
more info
  
enables zinc ion binding RCA
inferred from Reviewed Computational Analysis
more info
 PubMed 
Process Evidence Code Pubs
involved_in N-acylethanolamine metabolic process IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in N-acylethanolamine metabolic process IMP
Inferred from Mutant Phenotype
more info
 PubMed 
involved_in N-acylphosphatidylethanolamine metabolic process IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in N-acylphosphatidylethanolamine metabolic process IMP
Inferred from Mutant Phenotype
more info
 PubMed 
involved_in phospholipid catabolic process IEA
Inferred from Electronic Annotation
more info
  
Component Evidence Code Pubs
is_active_in cytoplasm IBA
Inferred from Biological aspect of Ancestor
more info
  
located_in membrane IEA
Inferred from Electronic Annotation
more info
  
is_active_in membrane-bounded organelle IBA
Inferred from Biological aspect of Ancestor
more info
  
located_in mitochondrial inner membrane IDA
Inferred from Direct Assay
more info
 PubMed 
located_in mitochondrial membrane IEA
Inferred from Electronic Annotation
more info
  
located_in mitochondrion HDA PubMed 
located_in mitochondrion IEA
Inferred from Electronic Annotation
more info
  

General protein information

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Preferred Names
N-acetylphosphatidylethanolamine-hydrolyzing phospholipase D
NP_015222.1
  • Protein with a role in maintaining mitochondrial morphology; also involved in maintaining normal cardiolipin levels; mitochondrial inner membrane protein; proposed to be involved in N-acylethanolamine metabolism; related to mammalian N-acylPE-specific phospholipase D

NCBI Reference Sequences (RefSeq)

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Genome Annotation

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference assembly

Genomic

  1. NC_001148.4 Reference assembly

    Range
    358000..359406 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. NM_001183917.1 → NP_015222.1  TPA: N-acetylphosphatidylethanolamine-hydrolyzing phospholipase D [Saccharomyces cerevisiae S288C]

    See identical proteins and their annotated locations for NP_015222.1

    Status: REVIEWED

    UniProtKB/Swiss-Prot
    D6W3R4, Q02883
    UniProtKB/TrEMBL
    A6ZWE8, B3LKX0, B5VT60, C7GJ57, C8ZIS7, G2WP78, N1P1K6
    Conserved Domains (1) summary
    cl23716
    Location:210 → 397
    metallo-hydrolase-like_MBL-fold; mainly hydrolytic enzymes and related proteins which carry out various biological functions; MBL-fold metallohydrolase domain
Nucleotide Protein
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
Q02883.1

Gene LinkOut

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