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MEI5 Mei5p [ Saccharomyces cerevisiae S288C ]

Gene ID: 855982, updated on 13-Nov-2024

Summary

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Official Symbol
MEI5
Official Full Name
Mei5p
Primary source
SGD:S000006042
Locus tag
YPL121C
See related
AllianceGenome:SGD:S000006042; FungiDB:YPL121C; VEuPathDB:YPL121C
Gene type
protein coding
RefSeq status
REVIEWED
Organism
Saccharomyces cerevisiae S288C (strain: S288C)
Lineage
Eukaryota; Fungi; Dikarya; Ascomycota; Saccharomycotina; Saccharomycetes; Saccharomycetales; Saccharomycetaceae; Saccharomyces
Also known as
LPH6
Summary
Involved in meiotic DNA recombinase assembly and reciprocal meiotic recombination. Located in condensed nuclear chromosome. [provided by Alliance of Genome Resources, Nov 2024]
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Genomic context

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See MEI5 in Genome Data Viewer
Location:
chromosome: XVI
Exon count:
1
Sequence:
Chromosome: XVI; NC_001148.4 (320962..321630, complement)

Chromosome XVI - NC_001148.4Genomic Context describing neighboring genes Neighboring gene ribonuclease T2 Neighboring gene TFIIH/NER complex subunit TFB2 Neighboring gene beclin 1 Neighboring gene uncharacterized protein

Genomic regions, transcripts, and products

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Genomic Sequence:
NC_001148.4

Go to nucleotide: Graphics FASTA GenBank

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?
  1. Mei5-Sae3 stabilizes Dmc1 nucleating clusters for efficient Dmc1 assembly on RPA-coated single-stranded DNA.
    Title: Mei5-Sae3 stabilizes Dmc1 nucleating clusters for efficient Dmc1 assembly on RPA-coated single-stranded DNA.
  2. The role of conserved amino acid residues of Sae3 in Mei5-Sae3 complex for Dmc1 assembly in meiotic recombination.
    Title: The role of conserved amino acid residues of Sae3 in Mei5-Sae3 complex for Dmc1 assembly in meiotic recombination.
  3. show the Mei5-Sae3 complex preferentially binds a fork-like DNA substrate to 3' overhanging DNA, single-stranded DNA or double-stranded DNA
    Title: The budding yeast Mei5-Sae3 complex interacts with Rad51 and preferentially binds a DNA fork structure.
  4. Mei5-Sae3 is a mediator of Dmc1 assembly during meiotic recombination in S. cerevisiae.
    Title: The Mei5-Sae3 protein complex mediates Dmc1 activity in Saccharomyces cerevisiae.
  5. Mei5 and Sae3 are loading factors for the RecA homolog Dmc1 recombinase and the Dmc1-Mei5-Sae3 complex is integrated onto Rad51 ensembles and plays both catalytic and structural roles in interhomolog recombination during meiosis.
    Title: A protein complex containing Mei5 and Sae3 promotes the assembly of the meiosis-specific RecA homolog Dmc1.
Submit: New GeneRIF Correction

Interactions

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Products Interactant Other Gene Complex Source Pubs Description

General gene information

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Homology

Gene Ontology Provided by SGD

Function Evidence Code Pubs
enables molecular_function ND
No biological Data available
more info
  
Process Evidence Code Pubs
involved_in DNA repair IEA
Inferred from Electronic Annotation
more info
  
involved_in meiotic DNA recombinase assembly IMP
Inferred from Mutant Phenotype
more info
 PubMed 
involved_in meiotic cell cycle IEA
Inferred from Electronic Annotation
more info
  
involved_in reciprocal meiotic recombination IMP
Inferred from Mutant Phenotype
more info
 PubMed 
involved_in sporulation resulting in formation of a cellular spore IEA
Inferred from Electronic Annotation
more info
  
Component Evidence Code Pubs
located_in condensed nuclear chromosome IDA
Inferred from Direct Assay
more info
 PubMed 
located_in nucleus HDA PubMed 
located_in nucleus IEA
Inferred from Electronic Annotation
more info
  

General protein information

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Preferred Names
Mei5p
NP_015204.1
  • Meiosis-specific protein involved in meiotic recombination; involved in DMC1-dependent meiotic recombination; forms heterodimer with Sae3p; proposed to be an assembly factor for Dmc1p

NCBI Reference Sequences (RefSeq)

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Genome Annotation

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference assembly

Genomic

  1. NC_001148.4 Reference assembly

    Range
    320962..321630 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. NM_001183935.1 → NP_015204.1  TPA: Mei5p [Saccharomyces cerevisiae S288C]

    See identical proteins and their annotated locations for NP_015204.1

    Status: REVIEWED

    UniProtKB/Swiss-Prot
    D6W3P6, P32489, Q02946
    UniProtKB/TrEMBL
    A6ZWD1, B3LKV3, B5VT45, C7GJ75, C8ZIQ8, G2WP60, N1NW23
    Conserved Domains (1) summary
    pfam10376
    Location:15 → 222
    Mei5; Double-strand recombination repair protein
Nucleotide Protein
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
P32489.2

Gene LinkOut

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