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RPL7B ribosomal 60S subunit protein L7B [ Saccharomyces cerevisiae S288C ]

Gene ID: 855903, updated on 2-Nov-2024

Summary

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Official Symbol
RPL7B
Official Full Name
ribosomal 60S subunit protein L7B
Primary source
SGD:S000006119
Locus tag
YPL198W
See related
AllianceGenome:SGD:S000006119; FungiDB:YPL198W; VEuPathDB:YPL198W
Gene type
protein coding
RefSeq status
REVIEWED
Organism
Saccharomyces cerevisiae S288C (strain: S288C)
Lineage
Eukaryota; Fungi; Dikarya; Ascomycota; Saccharomycotina; Saccharomycetes; Saccharomycetales; Saccharomycetaceae; Saccharomyces
Summary
Predicted to enable RNA binding activity. Predicted to be a structural constituent of ribosome. Involved in maturation of LSU-rRNA. Located in cytoplasm and nucleolus. Part of cytosolic large ribosomal subunit. Orthologous to human RPL7 (ribosomal protein L7). [provided by Alliance of Genome Resources, Nov 2024]
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Genomic context

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See RPL7B in Genome Data Viewer
Location:
chromosome: XVI
Exon count:
3
Sequence:
Chromosome: XVI; NC_001148.4 (173152..174702)

Chromosome XVI - NC_001148.4Genomic Context describing neighboring genes Neighboring gene Csm4p Neighboring gene uncharacterized protein Neighboring gene ncRNA Neighboring gene Oxr1p Neighboring gene Apl5p

Genomic regions, transcripts, and products

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Genomic Sequence:
NC_001148.4

Go to nucleotide: Graphics FASTA GenBank

Bibliography

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Related articles in PubMed

  1. The evolutionary relationships between homologs of ribosomal YL8 protein and YL8-like proteins. Mizuta K, et al. Curr Genet, 1995 Jun. PMID 8536309
  2. Human ribosomal protein L7 carries two nucleic acid-binding domains with distinct specificities. von Mikecz A, et al. Biochem Biophys Res Commun, 1999 May 19. PMID 10329420
  3. Association of ribosomal proteins with nascent transcripts in S. cerevisiae. Schroder PA, et al. RNA, 2005 Oct. PMID 16199762, Free PMC Article
  4. Paralog-Specific Functions of RPL7A and RPL7B Mediated by Ribosomal Protein or snoRNA Dosage in Saccharomyces cerevisiae. Palumbo RJ, et al. G3 (Bethesda), 2017 Feb 9. PMID 28007835, Free PMC Article
  5. Differential subcellular localization of ribosomal protein L7 paralogs in Saccharomyces cerevisiae. Kim TY, et al. Mol Cells, 2009 May 31. PMID 19466602

See all (94) citations in PubMed

GeneRIFs: Gene References Into Functions

What's a GeneRIF?
  1. Among mutants harboring a single native or chimeric RPL7 allele, expression from the RPL7A locus exceeded that from the RPL7B locus, and more Rpl7a was expressed from either locus than Rpl7b Phenotypic differences in tunicamycin sensitivity
    Title: Paralog-Specific Functions of RPL7A and RPL7B Mediated by Ribosomal Protein or snoRNA Dosage in Saccharomyces cerevisiae.
  2. L7 and L8 might establish RNP structures within assembling ribosomes necessary for the stable association and function of the A(3) assembly factors and for proper assembly of the neighborhoods containing domains I and II.
    Title: Ribosomal proteins L7 and L8 function in concert with six A₃ assembly factors to propagate assembly of domains I and II of 25S rRNA in yeast 60S ribosomal subunits.
Submit: New GeneRIF Correction

Interactions

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Products Interactant Other Gene Complex Source Pubs Description

General gene information

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Homology

Gene Ontology Provided by SGD

Function Evidence Code Pubs
enables RNA binding IBA
Inferred from Biological aspect of Ancestor
more info
  
enables RNA binding IEA
Inferred from Electronic Annotation
more info
  
enables structural constituent of ribosome IBA
Inferred from Biological aspect of Ancestor
more info
  
enables structural constituent of ribosome IC
Inferred by Curator
more info
 PubMed 
enables structural constituent of ribosome IEA
Inferred from Electronic Annotation
more info
  
Process Evidence Code Pubs
involved_in cytoplasmic translation IC
Inferred by Curator
more info
 PubMed 
involved_in maturation of LSU-rRNA IMP
Inferred from Mutant Phenotype
more info
 PubMed 
involved_in maturation of LSU-rRNA from tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA) IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in maturation of LSU-rRNA from tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA) IEA
Inferred from Electronic Annotation
more info
  
involved_in ribosomal large subunit biogenesis IDA
Inferred from Direct Assay
more info
 PubMed 
Component Evidence Code Pubs
located_in cytoplasm IDA
Inferred from Direct Assay
more info
 PubMed 
located_in cytoplasm IEA
Inferred from Electronic Annotation
more info
  
part_of cytosolic large ribosomal subunit IBA
Inferred from Biological aspect of Ancestor
more info
  
part_of cytosolic large ribosomal subunit IDA
Inferred from Direct Assay
more info
 PubMed 
located_in nucleolus IDA
Inferred from Direct Assay
more info
 PubMed 
part_of ribonucleoprotein complex IEA
Inferred from Electronic Annotation
more info
  
located_in ribosome IEA
Inferred from Electronic Annotation
more info
  

General protein information

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Preferred Names
ribosomal 60S subunit protein L7B
NP_015126.1
  • Ribosomal 60S subunit protein L7B; required for processing of 27SA3 pre-rRNA to 27SB pre-rRNA during assembly of large ribosomal subunit; depletion leads to a turnover of pre-rRNA; contains a conserved C-terminal Nucleic acid Binding Domain (NDB2); binds to Domain II of 25S and 5.8S rRNAs; homologous to mammalian ribosomal protein L7 and bacterial L30; RPL7B has a paralog, RPL7A, that arose from the whole genome duplication

NCBI Reference Sequences (RefSeq)

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Genome Annotation

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference assembly

Genomic

  1. NC_001148.4 Reference assembly

    Range
    173152..174702
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. NM_001184012.1 → NP_015126.1  TPA: ribosomal 60S subunit protein L7B [Saccharomyces cerevisiae S288C]

    See identical proteins and their annotated locations for NP_015126.1

    Status: REVIEWED

    UniProtKB/Swiss-Prot
    D6W3H1, Q12213
    UniProtKB/TrEMBL
    A6ZW56, B3LKN1, C8ZII1, G2WNY6
    Conserved Domains (1) summary
    TIGR01310
    Location:10 → 244
    uL30_euk; 60S ribosomal protein uL30, eukaryotic form
Nucleotide Protein
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
Q12213.3

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