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CSM4 Csm4p [ Saccharomyces cerevisiae S288C ]

Gene ID: 855901, updated on 2-Nov-2024

Summary

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Official Symbol
CSM4
Official Full Name
Csm4p
Primary source
SGD:S000006121
Locus tag
YPL200W
See related
AllianceGenome:SGD:S000006121; FungiDB:YPL200W; VEuPathDB:YPL200W
Gene type
protein coding
RefSeq status
REVIEWED
Organism
Saccharomyces cerevisiae S288C (strain: S288C)
Lineage
Eukaryota; Fungi; Dikarya; Ascomycota; Saccharomycotina; Saccharomycetes; Saccharomycetales; Saccharomycetaceae; Saccharomyces
Summary
Enables cytoskeleton-nuclear membrane anchor activity. Involved in homologous chromosome pairing at meiosis; meiotic telomere clustering; and regulation of reciprocal meiotic recombination. Located in chromosome, telomeric region; endoplasmic reticulum membrane; and nuclear outer membrane. Part of meiotic nuclear membrane microtubule tethering complex. [provided by Alliance of Genome Resources, Nov 2024]
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Genomic context

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See CSM4 in Genome Data Viewer
Location:
chromosome: XVI
Exon count:
1
Sequence:
Chromosome: XVI; NC_001148.4 (171484..171954)

Chromosome XVI - NC_001148.4Genomic Context describing neighboring genes Neighboring gene Aft2p Neighboring gene Yig1p Neighboring gene uncharacterized protein Neighboring gene ribosomal 60S subunit protein L7B Neighboring gene ncRNA

Genomic regions, transcripts, and products

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Genomic Sequence:
NC_001148.4

Go to nucleotide: Graphics FASTA GenBank

Bibliography

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Related articles in PubMed

  1. Sustained and rapid chromosome movements are critical for chromosome pairing and meiotic progression in budding yeast. Sonntag Brown M, et al. Genetics, 2011 May. PMID 21339478, Free PMC Article
  2. A selfish DNA element engages a meiosis-specific motor and telomeres for germ-line propagation. Sau S, et al. J Cell Biol, 2014 Jun 9. PMID 24914236, Free PMC Article
  3. Telomere-led meiotic chromosome movements: recent update in structure and function. Lee CY, et al. Nucleus, 2020 Jan 1. PMID 32412326, Free PMC Article
  4. Evidence for a dual role of actin in regulating chromosome organization and dynamics in yeast. Spichal M, et al. J Cell Sci, 2016 Feb 15. PMID 26763908
  5. The Nup2 meiotic-autonomous region relieves inhibition of Nup60 to promote progression of meiosis and sporulation in Saccharomyces cerevisiae. Komachi K, et al. Genetics, 2022 May 5. PMID 35302609, Free PMC Article

See all (27) citations in PubMed

GeneRIFs: Gene References Into Functions

What's a GeneRIF?
  1. Mps2 links Csm4 and Mps3 to form a telomere-associated LINC complex in budding yeast.
    Title: Mps2 links Csm4 and Mps3 to form a telomere-associated LINC complex in budding yeast.
  2. Csm4 is required for several distinct steps during meiotic recombination.
    Title: Csm4-dependent telomere movement on nuclear envelope promotes meiotic recombination.
  3. Unlike Ndj1, Csm4 is not required for meiosis-specific telomere association.
    Title: Csm4, in collaboration with Ndj1, mediates telomere-led chromosome dynamics and recombination during yeast meiosis.
Submit: New GeneRIF Correction

Interactions

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Products Interactant Other Gene Complex Source Pubs Description

General gene information

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Homology

Gene Ontology Provided by SGD

Function Evidence Code Pubs
enables cytoskeleton-nuclear membrane anchor activity IMP
Inferred from Mutant Phenotype
more info
 PubMed 
Process Evidence Code Pubs
involved_in chromosome segregation IEA
Inferred from Electronic Annotation
more info
  
involved_in homologous chromosome pairing at meiosis IMP
Inferred from Mutant Phenotype
more info
 PubMed 
involved_in meiotic cell cycle IEA
Inferred from Electronic Annotation
more info
  
involved_in meiotic chromosome segregation IMP
Inferred from Mutant Phenotype
more info
 PubMed 
involved_in meiotic telomere clustering IGI
Inferred from Genetic Interaction
more info
 PubMed 
involved_in meiotic telomere clustering IMP
Inferred from Mutant Phenotype
more info
 PubMed 
involved_in regulation of reciprocal meiotic recombination IMP
Inferred from Mutant Phenotype
more info
 PubMed 
involved_in sporulation resulting in formation of a cellular spore IEA
Inferred from Electronic Annotation
more info
  
Component Evidence Code Pubs
located_in chromosome, telomeric region IDA
Inferred from Direct Assay
more info
 PubMed 
located_in endoplasmic reticulum IEA
Inferred from Electronic Annotation
more info
  
located_in endoplasmic reticulum membrane IDA
Inferred from Direct Assay
more info
 PubMed 
located_in endoplasmic reticulum membrane IEA
Inferred from Electronic Annotation
more info
  
part_of meiotic nuclear membrane microtubule tethering complex IMP
Inferred from Mutant Phenotype
more info
 PubMed 
located_in membrane IEA
Inferred from Electronic Annotation
more info
  
located_in nuclear membrane IEA
Inferred from Electronic Annotation
more info
  
located_in nuclear outer membrane IDA
Inferred from Direct Assay
more info
 PubMed 
located_in nucleus IEA
Inferred from Electronic Annotation
more info
  

General protein information

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Preferred Names
Csm4p
NP_015124.1
  • Protein required for accurate chromosome segregation during meiosis; involved in meiotic telomere clustering (bouquet formation) and telomere-led rapid prophase movements; functions with meiosis-specific telomere-binding protein Ndj1p; CSM4 has a paralog, MPS2, that arose from the whole genome duplication

NCBI Reference Sequences (RefSeq)

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Genome Annotation

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference assembly

Genomic

  1. NC_001148.4 Reference assembly

    Range
    171484..171954
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. NM_001184014.1 → NP_015124.1  TPA: Csm4p [Saccharomyces cerevisiae S288C]

    See identical proteins and their annotated locations for NP_015124.1

    Status: REVIEWED

    UniProtKB/Swiss-Prot
    D6W3G9, Q08955
    UniProtKB/TrEMBL
    A6ZW54, B3LKM9, C7GN28, G2WNY4, N1NW99
Nucleotide Protein
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
Q08955.1

Gene LinkOut

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