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CHP1 ribosome-associated Tef1p biogenesis chaperone CHP1 [ Saccharomyces cerevisiae S288C ]

Gene ID: 855876, updated on 18-Sep-2024

Summary

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Official Symbol
CHP1
Official Full Name
ribosome-associated Tef1p biogenesis chaperone CHP1
Primary source
SGD:S000006146
Locus tag
YPL225W
See related
AllianceGenome:SGD:S000006146; FungiDB:YPL225W; VEuPathDB:YPL225W
Gene type
protein coding
RefSeq status
REVIEWED
Organism
Saccharomyces cerevisiae S288C (strain: S288C)
Lineage
Eukaryota; Fungi; Dikarya; Ascomycota; Saccharomycotina; Saccharomycetes; Saccharomycetales; Saccharomycetaceae; Saccharomyces
Summary
Located in cytoplasm. Orthologous to human PBDC1 (polysaccharide biosynthesis domain containing 1). [provided by Alliance of Genome Resources, Apr 2022]
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Genomic context

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See CHP1 in Genome Data Viewer
Location:
chromosome: XVI
Exon count:
1
Sequence:
Chromosome: XVI; NC_001148.4 (126006..126446)

Chromosome XVI - NC_001148.4Genomic Context describing neighboring genes Neighboring gene dolichyl-phosphate beta-glucosyltransferase Neighboring gene New1p Neighboring gene Mmt2p Neighboring gene Gre1p

Genomic regions, transcripts, and products

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Genomic Sequence:
NC_001148.4

Go to nucleotide: Graphics FASTA GenBank

Bibliography

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Related articles in PubMed

  1. Host factors that affect Ty3 retrotransposition in Saccharomyces cerevisiae. Aye M, et al. Genetics, 2004 Nov. PMID 15579677, Free PMC Article
  2. A ribosome-bound quality control complex triggers degradation of nascent peptides and signals translation stress. Brandman O, et al. Cell, 2012 Nov 21. PMID 23178123, Free PMC Article
  3. Systematic identification and functional screens of uncharacterized proteins associated with eukaryotic ribosomal complexes. Fleischer TC, et al. Genes Dev, 2006 May 15. PMID 16702403, Free PMC Article
  4. Mapping the functional yeast ABC transporter interactome. Snider J, et al. Nat Chem Biol, 2013 Sep. PMID 23831759, Free PMC Article
  5. Genome-wide bimolecular fluorescence complementation analysis of SUMO interactome in yeast. Sung MK, et al. Genome Res, 2013 Apr. PMID 23403034, Free PMC Article

See all (34) citations in PubMed

GeneRIFs: Gene References Into Functions

Interactions

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Products Interactant Other Gene Complex Source Pubs Description

General gene information

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Homology

Gene Ontology Provided by SGD

Function Evidence Code Pubs
enables misfolded protein binding IDA
Inferred from Direct Assay
more info
 PubMed 
enables nascent polypeptide-associated complex binding IDA
Inferred from Direct Assay
more info
 PubMed 
enables protein folding chaperone IDA
Inferred from Direct Assay
more info
 PubMed 
enables ribosome binding IDA
Inferred from Direct Assay
more info
 PubMed 
enables translation elongation factor binding IDA
Inferred from Direct Assay
more info
 PubMed 
Process Evidence Code Pubs
involved_in 'de novo' cotranslational protein folding IDA
Inferred from Direct Assay
more info
 PubMed 
Component Evidence Code Pubs
located_in cytoplasm HDA PubMed 
located_in cytoplasm IEA
Inferred from Electronic Annotation
more info
  

General protein information

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Preferred Names
ribosome-associated Tef1p biogenesis chaperone CHP1
NP_015099.1
  • Chaperone for eEF1A; ribosome-associated chaperone dedicated to facilitating high-level expression of eEF1A; transiently binds nascent GTPase domain of eEF1A as soon as it emerges from ribosome tunnel; forms complex with NAC by binding UBA domain of Egd2p; inactivation results in disturbed proteostasis and Hsf1p activation due to abberant eEF1A biogenesis; overlapping phenotypes support notion that Chp1p functions in same eEF1A biogenesis pathway as chaperone Zpr1p-Aim29p

NCBI Reference Sequences (RefSeq)

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Genome Annotation

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference assembly

Genomic

  1. NC_001148.4 Reference assembly

    Range
    126006..126446
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. NM_001184039.1 → NP_015099.1  TPA: ribosome-associated Tef1p biogenesis chaperone CHP1 [Saccharomyces cerevisiae S288C]

    See identical proteins and their annotated locations for NP_015099.1

    Status: REVIEWED

    UniProtKB/Swiss-Prot
    D6W3E5, Q08971
    UniProtKB/TrEMBL
    A6ZW30, B3LKK6, C7GU64, C8ZIF4, G2WNW0, N1NXX8
    Conserved Domains (1) summary
    pfam04669
    Location:15 → 142
    Polysacc_synt_4; Polysaccharide biosynthesis
Nucleotide Protein
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
Q08971.1

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