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AIF1 Aif1p [ Saccharomyces cerevisiae S288C ]

Gene ID: 855811, updated on 2-Nov-2024

Summary

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Official Symbol
AIF1
Official Full Name
Aif1p
Primary source
SGD:S000005357
Locus tag
YNR074C
See related
AllianceGenome:SGD:S000005357; FungiDB:YNR074C; VEuPathDB:YNR074C
Gene type
protein coding
RefSeq status
REVIEWED
Organism
Saccharomyces cerevisiae S288C (strain: S288C)
Lineage
Eukaryota; Fungi; Dikarya; Ascomycota; Saccharomycotina; Saccharomycetes; Saccharomycetales; Saccharomycetaceae; Saccharomyces
Also known as
CPD1
Summary
Predicted to enable electron-transferring-flavoprotein dehydrogenase activity; flavin adenine dinucleotide binding activity; and oxidoreductase activity, acting on NAD(P)H, quinone or similar compound as acceptor. Involved in positive regulation of apoptotic process and response to singlet oxygen. Located in mitochondrion and nucleus. Orthologous to human AIFM2 (AIF family member 2). [provided by Alliance of Genome Resources, Nov 2024]
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Genomic context

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See AIF1 in Genome Data Viewer
Location:
chromosome: XIV
Exon count:
1
Sequence:
Chromosome: XIV; NC_001146.8 (777602..778738, complement)

Chromosome XIV - NC_001146.8Genomic Context describing neighboring genes Neighboring gene hexose transporter HXT17 Neighboring gene putative mannitol dehydrogenase Neighboring gene Cos10p Neighboring gene uncharacterized protein

Genomic regions, transcripts, and products

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Genomic Sequence:
NC_001146.8

Go to nucleotide: Graphics FASTA GenBank

Bibliography

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Related articles in PubMed

  1. The anthracenedione compound bostrycin induces mitochondria-mediated apoptosis in the yeast Saccharomyces cerevisiae. Xu C, et al. FEMS Yeast Res, 2010 May. PMID 20345898
  2. Cdc73 is a major regulator of apoptosis-inducing factor 1 expression in Saccharomyces cerevisiae via H3K36 methylation. Saha N, et al. FEBS Lett, 2024 Mar. PMID 38467538
  3. Involvement of Aif1 in apoptosis triggered by lack of Hxk2 in the yeast Saccharomyces cerevisiae. Amigoni L, et al. FEMS Yeast Res, 2016 May. PMID 26895787
  4. CHCHD4 links AIF to the biogenesis of respiratory chain complex I. Modjtahedi N, et al. Mol Cell Oncol, 2016 Mar. PMID 27308594, Free PMC Article
  5. The phytopathogenic virulent effector protein RipI induces apoptosis in budding yeast Saccharomyces cerevisiae. Deng MY, et al. Toxicon, 2016 Oct. PMID 27616453

See all (49) citations in PubMed

GeneRIFs: Gene References Into Functions

What's a GeneRIF?
  1. Cdc73 is a major regulator of apoptosis-inducing factor 1 expression in Saccharomyces cerevisiae via H3K36 methylation.
    Title: Cdc73 is a major regulator of apoptosis-inducing factor 1 expression in Saccharomyces cerevisiae via H3K36 methylation.
  2. An AIF1 deletion mutant was resistant to anacardic acid-induced cell death, suggesting a key role of Aif1. Overexpression of Aif1 made cells highly susceptible to anacardic acid, further confirming that Aif1 mediates anacardic acid-induced apoptosis.
    Title: Apoptosis-inducing factor (Aif1) mediates anacardic acid-induced apoptosis in Saccharomyces cerevisiae.
  3. Deletion of AIF1 in hxk2Delta cells enhances survival after induction of apoptosis with both H2O2 and acetic acid, rescues the reduction of both growth rate and cell size, abrogates both H2O2 and acetic acid-induced ROS accumulation and decreases cell death, suggesting that Aif1 might be involved in both H2O2 and acetic acid-induced cell death in hxk2Delta cells.
    Title: Involvement of Aif1 in apoptosis triggered by lack of Hxk2 in the yeast Saccharomyces cerevisiae.
Submit: New GeneRIF Correction

Interactions

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Products Interactant Other Gene Complex Source Pubs Description

General gene information

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Homology

Gene Ontology Provided by SGD

Function Evidence Code Pubs
enables electron-transferring-flavoprotein dehydrogenase activity IBA
Inferred from Biological aspect of Ancestor
more info
  
enables flavin adenine dinucleotide binding IBA
Inferred from Biological aspect of Ancestor
more info
  
enables oxidoreductase activity IEA
Inferred from Electronic Annotation
more info
  
enables oxidoreductase activity, acting on NAD(P)H, quinone or similar compound as acceptor ISS
Inferred from Sequence or Structural Similarity
more info
 PubMed 
Process Evidence Code Pubs
involved_in apoptotic process IEA
Inferred from Electronic Annotation
more info
  
involved_in positive regulation of apoptotic process IMP
Inferred from Mutant Phenotype
more info
 PubMed 
involved_in respiratory electron transport chain IEA
Inferred from Electronic Annotation
more info
  
involved_in response to singlet oxygen IMP
Inferred from Mutant Phenotype
more info
 PubMed 
Component Evidence Code Pubs
is_active_in cytoplasm IBA
Inferred from Biological aspect of Ancestor
more info
  
located_in mitochondrial outer membrane IEA
Inferred from Electronic Annotation
more info
  
located_in mitochondrion IDA
Inferred from Direct Assay
more info
 PubMed 
located_in mitochondrion IEA
Inferred from Electronic Annotation
more info
  
located_in nucleus IDA
Inferred from Direct Assay
more info
 PubMed 
located_in nucleus IEA
Inferred from Electronic Annotation
more info
  

General protein information

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Preferred Names
Aif1p
NP_014472.1
  • Mitochondrial cell death effector; translocates to the nucleus in response to apoptotic stimuli; triggers apoptosis in cells lacking HXK2; homolog of mammalian Apoptosis-Inducing Factor, putative reductase

NCBI Reference Sequences (RefSeq)

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Genome Annotation

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference assembly

Genomic

  1. NC_001146.8 Reference assembly

    Range
    777602..778738 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. NM_001183251.1 → NP_014472.1  TPA: Aif1p [Saccharomyces cerevisiae S288C]

    See identical proteins and their annotated locations for NP_014472.1

    Status: REVIEWED

    UniProtKB/Swiss-Prot
    D6W1P9, P52923
    UniProtKB/TrEMBL
    A6ZSE8, B3LPH0, C7GKY8
    Conserved Domains (1) summary
    cl39093
    Location:21 → 293
    Pyr_redox_2; Pyridine nucleotide-disulphide oxidoreductase
Nucleotide Protein
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
P52923.1

Gene LinkOut

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