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MSO1 Mso1p [ Saccharomyces cerevisiae S288C ]

Gene ID: 855785, updated on 28-Oct-2024

Summary

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Official Symbol
MSO1
Official Full Name
Mso1p
Primary source
SGD:S000005332
Locus tag
YNR049C
See related
AllianceGenome:SGD:S000005332; FungiDB:YNR049C; VEuPathDB:YNR049C
Gene type
protein coding
RefSeq status
REVIEWED
Organism
Saccharomyces cerevisiae S288C (strain: S288C)
Lineage
Eukaryota; Fungi; Dikarya; Ascomycota; Saccharomycotina; Saccharomycetes; Saccharomycetales; Saccharomycetaceae; Saccharomyces
Summary
Involved in ascospore-type prospore membrane formation; membrane fusion; and vesicle docking involved in exocytosis. Located in several cellular components, including cellular bud membrane; cellular bud tip; and prospore membrane. Part of SNARE complex. [provided by Alliance of Genome Resources, Oct 2024]
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Genomic context

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See MSO1 in Genome Data Viewer
Location:
chromosome: XIV
Exon count:
1
Sequence:
Chromosome: XIV; NC_001146.8 (713023..713655, complement)

Chromosome XIV - NC_001146.8Genomic Context describing neighboring genes Neighboring gene serine/threonine protein kinase FPK1 Neighboring gene putative aminophospholipid translocase regulatory protein Neighboring gene saccharopine dehydrogenase (NADP+, L-glutamate-forming) Neighboring gene ncRNA

Genomic regions, transcripts, and products

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Genomic Sequence:
NC_001146.8

Go to nucleotide: Graphics FASTA GenBank

Bibliography

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Related articles in PubMed

  1. A conserved regulatory mode in exocytic membrane fusion revealed by Mso1p membrane interactions. Weber-Boyvat M, et al. Mol Biol Cell, 2013 Feb. PMID 23197474, Free PMC Article
  2. Characterization of the sec1-1 and sec1-11 mutations. Brummer MH, et al. Yeast, 2001 Dec. PMID 11748729
  3. Characterization of temperature-sensitive mutations in the yeast syntaxin 1 homologues Sso1p and Sso2p, and evidence of a distinct function for Sso1p in sporulation. Jäntti J, et al. J Cell Sci, 2002 Jan 15. PMID 11839791
  4. Mso1 is a novel component of the yeast exocytic SNARE complex. Castillo-Flores A, et al. J Biol Chem, 2005 Oct 7. PMID 16087665
  5. Molecular interactions position Mso1p, a novel PTB domain homologue, in the interface of the exocyst complex and the exocytic SNARE machinery in yeast. Knop M, et al. Mol Biol Cell, 2005 Oct. PMID 16030256, Free PMC Article

See all (36) citations in PubMed

GeneRIFs: Gene References Into Functions

What's a GeneRIF?
  1. The Mso1p membrane interactions are essential for correct subcellular localization of Mso1p-Sec1p complexes and for membrane fusion in Saccharomyces cerevisiae.
    Title: A conserved regulatory mode in exocytic membrane fusion revealed by Mso1p membrane interactions.
  2. Mso1p is in the interface of the exocyst complex, Sec4p, and the SNARE machinery, and reveal a novel layer of molecular conservation in the exocytosis machinery.
    Title: Molecular interactions position Mso1p, a novel PTB domain homologue, in the interface of the exocyst complex and the exocytic SNARE machinery in yeast.
  3. results suggest that Mso1 is a component of the exocytic SNARE complex and a possible ortholog of the Munc13/Mint proteins
    Title: Mso1 is a novel component of the yeast exocytic SNARE complex.
Submit: New GeneRIF Correction

Interactions

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Products Interactant Other Gene Complex Source Pubs Description

General gene information

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Homology

Gene Ontology Provided by SGD

Function Evidence Code Pubs
enables molecular_function ND
No biological Data available
more info
  
Process Evidence Code Pubs
involved_in ascospore-type prospore membrane formation IMP
Inferred from Mutant Phenotype
more info
 PubMed 
involved_in membrane fusion IMP
Inferred from Mutant Phenotype
more info
 PubMed 
involved_in protein transport IEA
Inferred from Electronic Annotation
more info
  
involved_in vesicle docking involved in exocytosis IDA
Inferred from Direct Assay
more info
 PubMed 
involved_in vesicle docking involved in exocytosis IMP
Inferred from Mutant Phenotype
more info
 PubMed 
Component Evidence Code Pubs
part_of SNARE complex IDA
Inferred from Direct Assay
more info
 PubMed 
located_in cellular bud membrane IDA
Inferred from Direct Assay
more info
 PubMed 
located_in cellular bud neck HDA PubMed 
located_in cellular bud neck IDA
Inferred from Direct Assay
more info
 PubMed 
located_in cellular bud tip HDA PubMed 
located_in cellular bud tip IDA
Inferred from Direct Assay
more info
 PubMed 
located_in cytoplasm HDA PubMed 
located_in cytosol HDA PubMed 
located_in nucleus HDA PubMed 
located_in plasma membrane IDA
Inferred from Direct Assay
more info
 PubMed 
located_in prospore membrane HDA PubMed 
located_in prospore membrane IDA
Inferred from Direct Assay
more info
 PubMed 

General protein information

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Preferred Names
Mso1p
NP_014447.3
  • Lipid-interacting protein in SNARE complex assembly machinery; acts at late step in secretion; interacts with membranes through two distinct binding sites; shows genetic and physical interactions with Sec1p; required for prospore membrane formation during sporulation; N-terminus closely associates with plasma membrane, C-terminus colocalizes with Sec4p on intracellular membranes; relocalizes from bud neck to nucleus upon DNA replication stress

NCBI Reference Sequences (RefSeq)

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Genome Annotation

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference assembly

Genomic

  1. NC_001146.8 Reference assembly

    Range
    713023..713655 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. NM_001183226.3 → NP_014447.3  TPA: Mso1p [Saccharomyces cerevisiae S288C]

    See identical proteins and their annotated locations for NP_014447.3

    Status: REVIEWED

    UniProtKB/Swiss-Prot
    D6W1M4, P53604
    UniProtKB/TrEMBL
    A6ZSC3, B3LPJ4, B5VR74, C7GLK8, C8ZFS8, G2WLA6, N1NY90
    Conserved Domains (1) summary
    pfam14475
    Location:31 → 70
    Mso1_Sec1_bdg; Sec1-binding region of Mso1
Nucleotide Protein
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
P53604.1

Gene LinkOut

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