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PBI2 Pbi2p [ Saccharomyces cerevisiae S288C ]

Gene ID: 855717, updated on 18-Sep-2024

Summary

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Official Symbol
PBI2
Official Full Name
Pbi2p
Primary source
SGD:S000004960
Locus tag
YNL015W
See related
AllianceGenome:SGD:S000004960; FungiDB:YNL015W; VEuPathDB:YNL015W
Gene type
protein coding
RefSeq status
REVIEWED
Organism
Saccharomyces cerevisiae S288C (strain: S288C)
Lineage
Eukaryota; Fungi; Dikarya; Ascomycota; Saccharomycotina; Saccharomycetes; Saccharomycetales; Saccharomycetaceae; Saccharomyces
Also known as
LMA1
Summary
Enables endopeptidase inhibitor activity. Involved in regulation of proteolysis and vacuole fusion, non-autophagic. Located in cytosol. [provided by Alliance of Genome Resources, Apr 2022]
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Genomic context

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See PBI2 in Genome Data Viewer
Location:
chromosome: XIV
Exon count:
1
Sequence:
Chromosome: XIV; NC_001146.8 (605384..605611)

Chromosome XIV - NC_001146.8Genomic Context describing neighboring genes Neighboring gene tRNA-Ile Neighboring gene Pub1p Neighboring gene translation elongation factor EF-3 Neighboring gene putative carboxylic ester hydrolase

Genomic regions, transcripts, and products

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Genomic Sequence:
NC_001146.8

Go to nucleotide: Graphics FASTA GenBank

Bibliography

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Related articles in PubMed

  1. Involvement of the C-terminal region of yeast proteinase B inhibitor 2 in its inhibitory action. Kojima S, et al. J Mol Biol, 1999 Feb 26. PMID 10024450
  2. Levels and turnover of the proteinase B inhibitors in yeast. Betz H. Biochim Biophys Acta, 1975 Sep 8. PMID 1100120
  3. Purification and molecular characterization of two inhibitors of yeast proteinase B. Maier K, et al. J Biol Chem, 1979 Sep 10. PMID 381308
  4. Natural occurrence and chemical modification of proteinase B inhibitors from yeast. Bünning P, et al. J Biol Chem, 1977 Aug 10. PMID 328499
  5. The proteinase yscA-inhibitor, IA3, gene. Studies of cytoplasmic proteinase inhibitor deficiency on yeast physiology. Schu P, et al. FEBS Lett, 1991 May 20. PMID 2037077

See all (38) citations in PubMed

GeneRIFs: Gene References Into Functions

Interactions

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Products Interactant Other Gene Complex Source Pubs Description

General gene information

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Homology

Gene Ontology Provided by SGD

Function Evidence Code Pubs
enables endopeptidase inhibitor activity IBA
Inferred from Biological aspect of Ancestor
more info
  
enables endopeptidase inhibitor activity IDA
Inferred from Direct Assay
more info
 PubMed 
enables serine-type endopeptidase inhibitor activity IEA
Inferred from Electronic Annotation
more info
  
Process Evidence Code Pubs
involved_in negative regulation of peptidase activity IEA
Inferred from Electronic Annotation
more info
  
involved_in protein transport IEA
Inferred from Electronic Annotation
more info
  
involved_in regulation of proteolysis IMP
Inferred from Mutant Phenotype
more info
 PubMed 
involved_in vacuole fusion, non-autophagic IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in vacuole fusion, non-autophagic IDA
Inferred from Direct Assay
more info
 PubMed 
Component Evidence Code Pubs
located_in cytoplasm HDA PubMed 
located_in cytoplasm IEA
Inferred from Electronic Annotation
more info
  
located_in cytosol HDA PubMed 
located_in cytosol IDA
Inferred from Direct Assay
more info
 PubMed 
located_in nucleus HDA PubMed 

General protein information

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Preferred Names
Pbi2p
NP_014383.1
  • Cytosolic inhibitor of vacuolar proteinase B (PRB1); required for efficient vacuole inheritance; with thioredoxin forms protein complex LMA1, which assists in priming SNARE molecules and promotes vacuole fusion; protein abundance increases in response to DNA replication stress

NCBI Reference Sequences (RefSeq)

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Genome Annotation

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference assembly

Genomic

  1. NC_001146.8 Reference assembly

    Range
    605384..605611
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. NM_001182854.1 → NP_014383.1  TPA: Pbi2p [Saccharomyces cerevisiae S288C]

    See identical proteins and their annotated locations for NP_014383.1

    Status: REVIEWED

    UniProtKB/Swiss-Prot
    D6W1G3, P01095, P0CT04, P0CT05
    UniProtKB/TrEMBL
    A6ZS62, B3LPQ0, C7GJF3, C8ZFL2, G2WL43, N1NWQ7
Nucleotide Protein
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
P0CT04.1

Gene LinkOut

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