U.S. flag

An official website of the United States government

Format

Send to:

Choose Destination

ARK1 serine/threonine protein kinase ARK1 [ Saccharomyces cerevisiae S288C ]

Gene ID: 855711, updated on 28-Oct-2024

Summary

Go to the top of the page Help
Official Symbol
ARK1
Official Full Name
serine/threonine protein kinase ARK1
Primary source
SGD:S000004965
Locus tag
YNL020C
See related
AllianceGenome:SGD:S000004965; FungiDB:YNL020C; VEuPathDB:YNL020C
Gene type
protein coding
RefSeq status
REVIEWED
Organism
Saccharomyces cerevisiae S288C (strain: S288C)
Lineage
Eukaryota; Fungi; Dikarya; Ascomycota; Saccharomycotina; Saccharomycetes; Saccharomycetales; Saccharomycetaceae; Saccharomyces
Summary
Enables protein serine/threonine kinase activity. Involved in actin filament organization and regulation of clathrin-dependent endocytosis. Located in actin cortical patch. Orthologous to human BMP2K (BMP2 inducible kinase). [provided by Alliance of Genome Resources, Oct 2024]
NEW
Try the new Gene table
Try the new Transcript table

Genomic context

Go to the top of the page Help
See ARK1 in Genome Data Viewer
Location:
chromosome: XIV
Exon count:
1
Sequence:
Chromosome: XIV; NC_001146.8 (595623..597539, complement)

Chromosome XIV - NC_001146.8Genomic Context describing neighboring genes Neighboring gene rRNA (cytosine-C5-)-methyltransferase RCM1 Neighboring gene histone deacetylase HDA1 Neighboring gene uncharacterized protein Neighboring gene uncharacterized protein

Genomic regions, transcripts, and products

Go to the top of the page Help
Genomic Sequence:
NC_001146.8

Go to nucleotide: Graphics FASTA GenBank

Bibliography

Go to the top of the pageHelp

Related articles in PubMed

  1. Corra: Computational framework and tools for LC-MS discovery and targeted mass spectrometry-based proteomics. Brusniak MY, et al. BMC Bioinformatics, 2008 Dec 16. PMID 19087345, Free PMC Article
  2. Measurement of bond vector orientations in invisible excited states of proteins. Vallurupalli P, et al. Proc Natl Acad Sci U S A, 2007 Nov 20. PMID 18006656, Free PMC Article
  3. A disordered encounter complex is central to the yeast Abp1p SH3 domain binding pathway. Gerlach GJ, et al. PLoS Comput Biol, 2020 Sep. PMID 32925900, Free PMC Article
  4. An Abp1-dependent route of endocytosis functions when the classical endocytic pathway in yeast is inhibited. Aghamohammadzadeh S, et al. PLoS One, 2014. PMID 25072293, Free PMC Article
  5. Dynamic phosphoregulation of the cortical actin cytoskeleton and endocytic machinery revealed by real-time chemical genetic analysis. Sekiya-Kawasaki M, et al. J Cell Biol, 2003 Sep 1. PMID 12952930, Free PMC Article

See all (60) citations in PubMed

GeneRIFs: Gene References Into Functions

What's a GeneRIF?
  1. Conserved Ark1-related kinases function in a TORC2 signaling network.
    Title: Conserved Ark1-related kinases function in a TORC2 signaling network.
  2. cells that overexpress AAK1 are adriamycin resistant
    Title: Endocytic Ark/Prk kinases play a critical role in adriamycin resistance in both yeast and mammalian cells.
  3. Data show that Sjl2p is specifically associated with cortical actin patches which aggregate upon loss of the actin-regulating kinases Ark1p and Prk1p.
    Title: Sjl2p is specifically involved in early steps of endocytosis intimately linked to actin dynamics via the Ark1p/Prk1p kinases.
Submit: New GeneRIF Correction

Interactions

Go to the top of the page Help
Products Interactant Other Gene Complex Source Pubs Description

General gene information

Go to the top of the page Help

Homology

Gene Ontology Provided by SGD

Function Evidence Code Pubs
enables ATP binding IEA
Inferred from Electronic Annotation
more info
  
enables histone H2AS1 kinase activity IEA
Inferred from Electronic Annotation
more info
  
enables protein kinase activity HDA PubMed 
enables protein kinase activity IEA
Inferred from Electronic Annotation
more info
  
enables protein serine kinase activity IEA
Inferred from Electronic Annotation
more info
  
enables protein serine/threonine kinase activity IBA
Inferred from Biological aspect of Ancestor
more info
  
enables protein serine/threonine kinase activity IDA
Inferred from Direct Assay
more info
 PubMed 
enables protein serine/threonine kinase activity IEA
Inferred from Electronic Annotation
more info
  
enables protein serine/threonine kinase activity IMP
Inferred from Mutant Phenotype
more info
 PubMed 
Process Evidence Code Pubs
involved_in actin cortical patch assembly IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in actin filament organization IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in actin filament organization IMP
Inferred from Mutant Phenotype
more info
 PubMed 
involved_in chromatin remodeling IEA
Inferred from Electronic Annotation
more info
  
involved_in phosphorylation IEA
Inferred from Electronic Annotation
more info
  
involved_in protein phosphorylation IEA
Inferred from Electronic Annotation
more info
  
involved_in regulation of clathrin-dependent endocytosis IGI
Inferred from Genetic Interaction
more info
 PubMed 
involved_in regulation of clathrin-dependent endocytosis IMP
Inferred from Mutant Phenotype
more info
 PubMed 
Component Evidence Code Pubs
located_in actin cortical patch IDA
Inferred from Direct Assay
more info
 PubMed 
located_in actin cortical patch IEA
Inferred from Electronic Annotation
more info
  
is_active_in cytoplasm IBA
Inferred from Biological aspect of Ancestor
more info
  
located_in cytoplasm IEA
Inferred from Electronic Annotation
more info
  
located_in cytoskeleton IEA
Inferred from Electronic Annotation
more info
  
located_in mating projection tip HDA PubMed 

General protein information

Go to the top of the page Help
Preferred Names
serine/threonine protein kinase ARK1
NP_014378.1
  • Ser/Thr protein kinase; phosphorylates Pan1p-Sla1p-End3p protein complex subunits, Pan1p and Sla1p; involved in regulation of the cortical actin cytoskeleton and endocytosis; functional overlap with PRK1

NCBI Reference Sequences (RefSeq)

Go to the top of the page Help

NEW Try the new Transcript table

Genome Annotation

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference assembly

Genomic

  1. NC_001146.8 Reference assembly

    Range
    595623..597539 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. NM_001182859.1 → NP_014378.1  TPA: serine/threonine protein kinase ARK1 [Saccharomyces cerevisiae S288C]

    See identical proteins and their annotated locations for NP_014378.1

    Status: REVIEWED

    UniProtKB/Swiss-Prot
    D6W1F9, P53974
    UniProtKB/TrEMBL
    A6ZS46, G2WM71, N1P4L5
    Conserved Domains (1) summary
    cd14037
    Location:18 → 301
    STKc_NAK_like; Catalytic domain of Numb-Associated Kinase (NAK)-like Serine/Threonine kinases
Nucleotide Protein
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
P53974.1

Gene LinkOut

The following LinkOut resources are supplied by external providers. These providers are responsible for maintaining the links.

Other Literature Sources
Molecular Biology Databases
Research Materials
Tools