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HHF2 histone H4 [ Saccharomyces cerevisiae S288C ]

Gene ID: 855701, updated on 29-Jun-2024

Summary

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Gene symbol
HHF2
Gene description
histone H4
Primary source
FungiDB:YNL030W
Locus tag
YNL030W
See related
SGD:S000004975; AllianceGenome:SGD:S000004975; VEuPathDB:YNL030W
Gene type
protein coding
RefSeq status
REVIEWED
Organism
Saccharomyces cerevisiae S288C (strain: S288C)
Lineage
Eukaryota; Fungi; Dikarya; Ascomycota; Saccharomycotina; Saccharomycetes; Saccharomycetales; Saccharomycetaceae; Saccharomyces
Summary
Predicted to enable DNA binding activity. Involved in histone H3-K79 methylation; sexual sporulation resulting in formation of a cellular spore; and transfer RNA gene-mediated silencing. Part of replication fork protection complex. Orthologous to several human genes including H4C15 (H4 clustered histone 15). [provided by Alliance of Genome Resources, Apr 2022]
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Genomic context

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See HHF2 in Genome Data Viewer
Location:
chromosome: XIV
Exon count:
1
Sequence:
Chromosome: XIV; NC_001146.8 (576727..577038)

Chromosome XIV - NC_001146.8Genomic Context describing neighboring genes Neighboring gene putative tyrosine protein phosphatase SIW14 Neighboring gene histone H3 Neighboring gene putative mannosyltransferase Neighboring gene DNA-binding transcription factor CRZ1

Genomic regions, transcripts, and products

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Genomic Sequence:
NC_001146.8

Go to nucleotide: Graphics FASTA GenBank

Bibliography

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Related articles in PubMed

  1. A genomic integration method for the simultaneous visualization of endogenous mRNAs and their translation products in living yeast. Haim-Vilmovsky L, et al. RNA, 2011 Dec. PMID 22025736, Free PMC Article
  2. Identification of novel histone post-translational modifications by peptide mass fingerprinting. Zhang L, et al. Chromosoma, 2003 Aug. PMID 12937907
  3. Crosstalk between chromatin structure, cohesin activity and transcription. Maya-Miles D, et al. Epigenetics Chromatin, 2019 Jul 22. PMID 31331360, Free PMC Article
  4. Regulated acetylation and deacetylation of H4 K16 is essential for efficient NER in Saccharomyces cerevisiae. Ray A, et al. DNA Repair (Amst), 2018 Dec. PMID 30274769
  5. Positive Charge of Arginine Residues on Histone H4 Tail Is Required for Maintenance of Mating Type in Saccharomyces cerevisiae. Yeom S, et al. J Microbiol Biotechnol, 2018 Sep 28. PMID 30176714

See all (386) citations in PubMed

GeneRIFs: Gene References Into Functions

What's a GeneRIF?
  1. Data show that DNA replication largely results in nucleosomes bearing exclusively old or new H3-H4.
    Title: Splitting of H3-H4 tetramers at transcriptionally active genes undergoing dynamic histone exchange.
  2. analysis of the histone H3 and histone H4 core modifiable residues in Saccharomyces cerevisiae
    Title: Insights into the role of histone H3 and histone H4 core modifiable residues in Saccharomyces cerevisiae.
Submit: New GeneRIF Correction

Pathways from PubChem

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Interactions

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Products Interactant Other Gene Complex Source Pubs Description

General gene information

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Homology

Gene Ontology Provided by SGD

Function Evidence Code Pubs
enables DNA binding IEA
Inferred from Electronic Annotation
more info
  
enables DNA binding TAS
Traceable Author Statement
more info
 PubMed 
enables protein heterodimerization activity IEA
Inferred from Electronic Annotation
more info
  
enables structural constituent of chromatin IEA
Inferred from Electronic Annotation
more info
  
Process Evidence Code Pubs
involved_in chromatin organization TAS
Traceable Author Statement
more info
 PubMed 
Component Evidence Code Pubs
located_in chromosome IEA
Inferred from Electronic Annotation
more info
  
part_of nucleosome IEA
Inferred from Electronic Annotation
more info
  
part_of nucleosome TAS
Traceable Author Statement
more info
 PubMed 
located_in nucleus IEA
Inferred from Electronic Annotation
more info
  
part_of protein-containing complex IEA
Inferred from Electronic Annotation
more info
  

General protein information

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Preferred Names
histone H4
NP_014368.1
  • Histone H4; core histone protein required for chromatin assembly and chromosome function; one of two identical histone proteins (see also HHF1); contributes to telomeric silencing; N-terminal domain involved in maintaining genomic integrity

NCBI Reference Sequences (RefSeq)

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Genome Annotation

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference assembly

Genomic

  1. NC_001146.8 Reference assembly

    Range
    576727..577038
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. NM_001182869.1 → NP_014368.1  TPA: histone H4 [Saccharomyces cerevisiae S288C]

    See identical proteins and their annotated locations for NP_014368.1

    Status: REVIEWED

    UniProtKB/Swiss-Prot
    D6VQ10, P02309
    UniProtKB/TrEMBL
    A0A6A5Q1V3, A6ZKV6, B3LND1, C7GM41, C8Z404, C8ZFK7, G2W917, N1PAQ9
    Conserved Domains (1) summary
    PTZ00015
    Location:18 → 101
    PTZ00015; histone H4; Provisional
Nucleotide Protein
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
P02309.2

Gene LinkOut

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Other Literature Sources
Molecular Biology Databases
Research Materials
Miscellaneous