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AQR1 [ Saccharomyces cerevisiae S288C ]

Gene ID: 855660, updated on 22-Aug-2024

Summary

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Official Symbol
AQR1
Primary source
FungiDB:YNL065W
Locus tag
YNL065W
See related
SGD:S000005009; AllianceGenome:SGD:S000005009; VEuPathDB:YNL065W
Gene type
protein coding
RefSeq status
REVIEWED
Organism
Saccharomyces cerevisiae S288C (strain: S288C)
Lineage
Eukaryota; Fungi; Dikarya; Ascomycota; Saccharomycotina; Saccharomycetes; Saccharomycetales; Saccharomycetaceae; Saccharomyces
Summary
Enables monocarboxylic acid transmembrane transporter activity and xenobiotic transmembrane transporter activity. Involved in amino acid export across plasma membrane and monocarboxylic acid transport. Located in plasma membrane. [provided by Alliance of Genome Resources, Apr 2022]
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Genomic context

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Location:
chromosome: XIV
Exon count:
1
Sequence:
Chromosome: XIV; NC_001146.8 (503724..505484)

Chromosome XIV - NC_001146.8Genomic Context describing neighboring genes Neighboring gene ribosomal 60S subunit protein L9B Neighboring gene putative glucosidase SUN4 Neighboring gene type I HSP40 co-chaperone YDJ1 Neighboring gene S-adenosylmethionine-dependent methyltransferase

Genomic regions, transcripts, and products

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Genomic Sequence:
NC_001146.8

Go to nucleotide: Graphics FASTA GenBank

Bibliography

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Related articles in PubMed

  1. AQR1 gene (ORF YNL065w) encodes a plasma membrane transporter of the major facilitator superfamily that confers resistance to short-chain monocarboxylic acids and quinidine in Saccharomyces cerevisiae. Tenreiro S, et al. Biochem Biophys Res Commun, 2002 Apr 5. PMID 11922628
  2. Saccharomyces cerevisiae Aqr1 is an internal-membrane transporter involved in excretion of amino acids. Velasco I, et al. Eukaryot Cell, 2004 Dec. PMID 15590823, Free PMC Article
  3. Combined roles of exporters in acetic acid tolerance in Saccharomyces cerevisiae. Zhang X, et al. Biotechnol Biofuels Bioprod, 2022 Jun 18. PMID 35717394, Free PMC Article
  4. Overlapping Roles of Yeast Transporters Aqr1, Qdr2, and Qdr3 in Amino Acid Excretion and Cross-Feeding of Lactic Acid Bacteria. Kapetanakis GC, et al. Front Microbiol, 2021. PMID 34887841, Free PMC Article
  5. The intralumenal fragment pathway mediates ESCRT-independent surface transporter down-regulation. McNally EK, et al. Nat Commun, 2018 Dec 18. PMID 30560896, Free PMC Article

See all (28) citations in PubMed

GeneRIFs: Gene References Into Functions

What's a GeneRIF?
  1. Aqr1 catalyzes transport of excess amino acids into vesicles, which then release them in the extracellular space by exocytosis
    Title: Saccharomyces cerevisiae Aqr1 is an internal-membrane transporter involved in excretion of amino acids.
Submit: New GeneRIF Correction

Interactions

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Products Interactant Other Gene Complex Source Pubs Description

General gene information

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Homology

Gene Ontology Provided by SGD

Function Evidence Code Pubs
enables monocarboxylic acid transmembrane transporter activity IMP
Inferred from Mutant Phenotype
more info
 PubMed 
enables threonine efflux transmembrane transporter activity IMP
Inferred from Mutant Phenotype
more info
 PubMed 
enables transmembrane transporter activity IBA
Inferred from Biological aspect of Ancestor
more info
  
enables transmembrane transporter activity IEA
Inferred from Electronic Annotation
more info
  
enables xenobiotic transmembrane transporter activity IMP
Inferred from Mutant Phenotype
more info
 PubMed 
Process Evidence Code Pubs
involved_in amino acid export across plasma membrane IGI
Inferred from Genetic Interaction
more info
 PubMed 
involved_in amino acid export across plasma membrane IMP
Inferred from Mutant Phenotype
more info
 PubMed 
involved_in monocarboxylic acid transport IMP
Inferred from Mutant Phenotype
more info
 PubMed 
involved_in threonine transport IEA
Inferred from Electronic Annotation
more info
  
involved_in transmembrane transport IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in transmembrane transport IEA
Inferred from Electronic Annotation
more info
  
involved_in transmembrane transport IMP
Inferred from Mutant Phenotype
more info
 PubMed 
involved_in xenobiotic transport IEA
Inferred from Electronic Annotation
more info
  
Component Evidence Code Pubs
located_in cell periphery HDA PubMed 
located_in cytoplasm HDA PubMed 
located_in fungal-type vacuole HDA PubMed 
located_in membrane IEA
Inferred from Electronic Annotation
more info
  
located_in plasma membrane HDA PubMed 
is_active_in plasma membrane IBA
Inferred from Biological aspect of Ancestor
more info
  
is_active_in plasma membrane IDA
Inferred from Direct Assay
more info
 PubMed 
located_in plasma membrane IDA
Inferred from Direct Assay
more info
 PubMed 

General protein information

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Preferred Names
Aqr1p
NP_014334.3
  • Plasma membrane transporter of the major facilitator superfamily; involved in the excretion of excess amino acids; member of the 12-spanner drug:H(+) antiporter DHA1 family; confers resistance to short-chain monocarboxylic acids and quinidine; relocalizes from plasma membrane to cytoplasm upon DNA replication stress; AQR1 has a paralog, QDR1, that arose from the whole genome duplication

NCBI Reference Sequences (RefSeq)

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Genome Annotation

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference assembly

Genomic

  1. NC_001146.8 Reference assembly

    Range
    503724..505484
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. NM_001182903.3 → NP_014334.3  TPA: Aqr1p [Saccharomyces cerevisiae S288C]

    See identical proteins and their annotated locations for NP_014334.3

    Status: REVIEWED

    UniProtKB/Swiss-Prot
    D6W1B5, P53943, Q6B1F8
    UniProtKB/TrEMBL
    A6ZS15, N1NZH9
    Conserved Domains (1) summary
    cd17323
    Location:103 → 553
    MFS_Tpo1_MDR_like; Yeast Polyamine transporter 1 (Tpo1) and similar multidrug resistance (MDR) transporters of the Major Facilitator Superfamily
Nucleotide Protein
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
P53943.1

Gene LinkOut

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