AAH1 adenine deaminase [Saccharomyces cerevisiae S288C] - Gene

Summary

Official Symbol: AAH1
Official Full Name: adenine deaminase
Primary source: SGD:S000005085
Locus tag: YNL141W
See related: AllianceGenome:SGD:S000005085; FungiDB:YNL141W; VEuPathDB:YNL141W
Gene type: protein coding
RefSeq status: REVIEWED
Organism: Saccharomyces cerevisiae S288C (strain: S288C)
Lineage: Eukaryota; Fungi; Dikarya; Ascomycota; Saccharomycotina; Saccharomycetes; Saccharomycetales; Saccharomycetaceae; Saccharomyces
Summary: Enables adenine deaminase activity. Involved in adenine catabolic process and hypoxanthine salvage. Located in cytoplasm and nucleus. Human ortholog(s) of this gene implicated in adenosine deaminase deficiency; asthma; and severe combined immunodeficiency. Orthologous to human ADA (adenosine deaminase). [provided by Alliance of Genome Resources, Apr 2022]
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Chromosome XIV - NC_001146.8 Genomic Context describing neighboring genes

Go to nucleotide: Graphics FASTA GenBank

Genetic investigation of purine nucleotide imbalance in Saccharomyces cerevisiae.
Title: Genetic investigation of purine nucleotide imbalance in Saccharomyces cerevisiae.
genes ADE12, ADE13, AAH1, and HAM1 controlling processes of purine utilization and interconversion in yeast make the greatest contribution to the system of protection against the toxic and mutagenic action of the examined analogs.
Title: [Genetic control of metabolism of mutagenic purine base analogs 6-hydroxylaminopurine and 2-amino-6-hydroxylaminopurine in yeast Saccharomyces cerevisiae].
Saf1p targets Aah1p for proteasome-dependent degradation upon entry into quiescence.
Title: Proteasome- and SCF-dependent degradation of yeast adenine deaminase upon transition from proliferation to quiescence requires a new F-box protein named Saf1p.

Submit: New GeneRIF Correction

Products	Interactant	Other Gene	Complex	Source	Pubs	Description

Function	Evidence Code	Pubs
enables adenine deaminase activity	IBA Inferred from Biological aspect of Ancestor more info
enables adenine deaminase activity	IDA Inferred from Direct Assay more info	PubMed
enables adenine deaminase activity	IEA Inferred from Electronic Annotation more info
enables adenine deaminase activity	IMP Inferred from Mutant Phenotype more info	PubMed
enables hydrolase activity	IEA Inferred from Electronic Annotation more info
enables metal ion binding	IEA Inferred from Electronic Annotation more info
enables zinc ion binding	IEA Inferred from Electronic Annotation more info
enables zinc ion binding	RCA inferred from Reviewed Computational Analysis more info	PubMed

Process	Evidence Code	Pubs
involved_in adenine catabolic process	IBA Inferred from Biological aspect of Ancestor more info
involved_in adenine catabolic process	IDA Inferred from Direct Assay more info	PubMed
involved_in adenine catabolic process	IEA Inferred from Electronic Annotation more info
involved_in adenine catabolic process	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in hypoxanthine salvage	IBA Inferred from Biological aspect of Ancestor more info
involved_in hypoxanthine salvage	IDA Inferred from Direct Assay more info	PubMed
involved_in hypoxanthine salvage	IEA Inferred from Electronic Annotation more info
involved_in hypoxanthine salvage	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in nucleotide metabolic process	IEA Inferred from Electronic Annotation more info
involved_in purine ribonucleoside monophosphate biosynthetic process	IEA Inferred from Electronic Annotation more info
involved_in purine-containing compound salvage	IDA Inferred from Direct Assay more info	PubMed
involved_in purine-containing compound salvage	IMP Inferred from Mutant Phenotype more info	PubMed

Component	Evidence Code	Pubs
located_in cytoplasm	HDA more info	PubMed
located_in cytoplasm	IEA Inferred from Electronic Annotation more info
located_in nucleus	HDA more info	PubMed
located_in nucleus	IEA Inferred from Electronic Annotation more info

NP_014258.1

Adenine deaminase (adenine aminohydrolase); converts adenine to hypoxanthine; involved in purine salvage; transcriptionally regulated by nutrient levels and growth phase; Aah1p degraded upon entry into quiescence via SCF and the proteasome