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BNI5 Bni5p [ Saccharomyces cerevisiae S288C ]

Gene ID: 855555, updated on 2-Nov-2024

Summary

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Official Symbol
BNI5
Official Full Name
Bni5p
Primary source
SGD:S000005110
Locus tag
YNL166C
See related
AllianceGenome:SGD:S000005110; FungiDB:YNL166C; VEuPathDB:YNL166C
Gene type
protein coding
RefSeq status
REVIEWED
Organism
Saccharomyces cerevisiae S288C (strain: S288C)
Lineage
Eukaryota; Fungi; Dikarya; Ascomycota; Saccharomycotina; Saccharomycetes; Saccharomycetales; Saccharomycetaceae; Saccharomyces
Summary
Enables myosin II tail binding activity and protein-macromolecule adaptor activity. Involved in protein localization to cell division site and septin ring assembly. Located in cellular bud neck septin ring. [provided by Alliance of Genome Resources, Nov 2024]
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Genomic context

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See BNI5 in Genome Data Viewer
Location:
chromosome: XIV
Exon count:
1
Sequence:
Chromosome: XIV; NC_001146.8 (322219..323565, complement)

Chromosome XIV - NC_001146.8Genomic Context describing neighboring genes Neighboring gene Fmp41p Neighboring gene Sko1p Neighboring gene uncharacterized protein Neighboring gene Ibd2p

Genomic regions, transcripts, and products

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Genomic Sequence:
NC_001146.8

Go to nucleotide: Graphics FASTA GenBank

Bibliography

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Related articles in PubMed

  1. Requirement of Bni5 phosphorylation for bud morphogenesis in Saccharomyces cerevisiae. Nam SC, et al. J Microbiol, 2007 Feb. PMID 17342053
  2. Effects of Bni5 Binding on Septin Filament Organization. Booth EA, et al. J Mol Biol, 2016 Dec 4. PMID 27806918, Free PMC Article
  3. Phosphorylation-dependent septin interaction of Bni5 is important for cytokinesis. Nam SC, et al. J Microbiol, 2007 Jun. PMID 17618228
  4. Biphasic targeting and cleavage furrow ingression directed by the tail of a myosin II. Fang X, et al. J Cell Biol, 2010 Dec 27. PMID 21173112, Free PMC Article
  5. The LKB1-like Kinase Elm1 Controls Septin Hourglass Assembly and Stability by Regulating Filament Pairing. Marquardt J, et al. Curr Biol, 2020 Jun 22. PMID 32386534, Free PMC Article

See all (53) citations in PubMed

GeneRIFs: Gene References Into Functions

What's a GeneRIF?
  1. The authors found that the interaction of Bni5 with the terminal subunit (Cdc11) at the junctions between adjacent hetero-octamers in paired filaments is highly cooperative.
    Title: Effects of Bni5 Binding on Septin Filament Organization.
  2. Bni5 phosphorylation is important for interaction with septin component Cdc11 and for timely delocalization from septin filament at late mitosis.
    Title: Phosphorylation-dependent septin interaction of Bni5 is important for cytokinesis.
  3. These results suggest that bud morphogenesis and mitotic entry are positively regulated by phosphorylation-dependent function of Bni5 which is under the control of Swe1 morphogenesis pathway.
    Title: Requirement of Bni5 phosphorylation for bud morphogenesis in Saccharomyces cerevisiae.
Submit: New GeneRIF Correction

Interactions

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Products Interactant Other Gene Complex Source Pubs Description

General gene information

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Homology

Gene Ontology Provided by SGD

Function Evidence Code Pubs
enables myosin II tail binding IPI
Inferred from Physical Interaction
more info
 PubMed 
enables protein-macromolecule adaptor activity IGI
Inferred from Genetic Interaction
more info
 PubMed 
Process Evidence Code Pubs
involved_in protein localization to cell division site IMP
Inferred from Mutant Phenotype
more info
 PubMed 
involved_in septin ring assembly IMP
Inferred from Mutant Phenotype
more info
 PubMed 
Component Evidence Code Pubs
located_in cellular bud neck HDA PubMed 
located_in cellular bud neck IDA
Inferred from Direct Assay
more info
 PubMed 
located_in cellular bud neck IEA
Inferred from Electronic Annotation
more info
  
located_in cellular bud neck septin ring IDA
Inferred from Direct Assay
more info
 PubMed 
located_in cytoplasm IEA
Inferred from Electronic Annotation
more info
  

General protein information

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Preferred Names
Bni5p
NP_014233.1
  • Linker protein responsible for recruitment of myosin to the bud neck; interacts with the C-terminal extensions of septins Cdc11p and Shs1p and binds Myo1p to promote cytokinesis

NCBI Reference Sequences (RefSeq)

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Genome Annotation

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference assembly

Genomic

  1. NC_001146.8 Reference assembly

    Range
    322219..323565 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. NM_001183004.1 → NP_014233.1  TPA: Bni5p [Saccharomyces cerevisiae S288C]

    See identical proteins and their annotated locations for NP_014233.1

    Status: REVIEWED

    UniProtKB/Swiss-Prot
    D6W116, P53890
    UniProtKB/TrEMBL
    A6ZRR7, C7GTE3, C8ZG62, N1NXS5
Nucleotide Protein
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
P53890.1

Gene LinkOut

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