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GCR2 Gcr2p [ Saccharomyces cerevisiae S288C ]

Gene ID: 855522, updated on 28-Oct-2024

Summary

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Official Symbol
GCR2
Official Full Name
Gcr2p
Primary source
SGD:S000005143
Locus tag
YNL199C
See related
AllianceGenome:SGD:S000005143; FungiDB:YNL199C; VEuPathDB:YNL199C
Gene type
protein coding
RefSeq status
REVIEWED
Organism
Saccharomyces cerevisiae S288C (strain: S288C)
Lineage
Eukaryota; Fungi; Dikarya; Ascomycota; Saccharomycotina; Saccharomycetes; Saccharomycetales; Saccharomycetaceae; Saccharomyces
Summary
Enables RNA polymerase II-specific DNA-binding transcription factor binding activity and transcription coregulator activity. Involved in regulation of DNA-templated transcription and regulation of glycolytic process. Located in nuclear envelope. [provided by Alliance of Genome Resources, Oct 2024]
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Genomic context

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See GCR2 in Genome Data Viewer
Location:
chromosome: XIV
Exon count:
1
Sequence:
Chromosome: XIV; NC_001146.8 (264926..266530, complement)

Chromosome XIV - NC_001146.8Genomic Context describing neighboring genes Neighboring gene Psy2p Neighboring gene NADHX epimerase Neighboring gene mRNA-binding protein WHI3 Neighboring gene Slz1p

Genomic regions, transcripts, and products

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Genomic Sequence:
NC_001146.8

Go to nucleotide: Graphics FASTA GenBank

Bibliography

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Related articles in PubMed

  1. The GCR2 gene is required for the transcriptional activation of retrotransposon Ty2-917 in Saccharomyces cerevisiae. Türkel S. Biol Pharm Bull, 2002 Sep. PMID 12230120
  2. Metabolic Changes Induced by Deletion of Transcriptional Regulator GCR2 in Xylose-Fermenting Saccharomyces cerevisiae. Shin M, et al. Microorganisms, 2020 Sep 29. PMID 33003408, Free PMC Article
  3. Role of GCR2 in transcriptional activation of yeast glycolytic genes. Uemura H, et al. Mol Cell Biol, 1992 Sep. PMID 1508187, Free PMC Article
  4. Influence of low glycolytic activities in gcr1 and gcr2 mutants on the expression of other metabolic pathway genes in Saccharomyces cerevisiae. Sasaki H, et al. Yeast, 2005 Jan 30. PMID 15645478
  5. The gcr (glycolysis regulation) mutation of Saccharomyces cerevisiae. Clifton D, et al. J Biol Chem, 1981 Dec 25. PMID 7031056

See all (93) citations in PubMed

GeneRIFs: Gene References Into Functions

Interactions

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Products Interactant Other Gene Complex Source Pubs Description

General gene information

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Homology

Gene Ontology Provided by SGD

Function Evidence Code Pubs
enables RNA polymerase II-specific DNA-binding transcription factor binding IDA
Inferred from Direct Assay
more info
 PubMed 
enables transcription coregulator activity IGI
Inferred from Genetic Interaction
more info
 PubMed 
Process Evidence Code Pubs
involved_in negative regulation of transcription by RNA polymerase II IDA
Inferred from Direct Assay
more info
 PubMed 
involved_in negative regulation of transcription by RNA polymerase II IMP
Inferred from Mutant Phenotype
more info
 PubMed 
involved_in positive regulation of antisense RNA transcription IDA
Inferred from Direct Assay
more info
 PubMed 
involved_in positive regulation of antisense RNA transcription IMP
Inferred from Mutant Phenotype
more info
 PubMed 
involved_in positive regulation of ribosomal protein gene transcription by RNA polymerase II IMP
Inferred from Mutant Phenotype
more info
 PubMed 
involved_in positive regulation of transcription by RNA polymerase II IMP
Inferred from Mutant Phenotype
more info
 PubMed 
involved_in regulation of glycolytic process IMP
Inferred from Mutant Phenotype
more info
 PubMed 
Component Evidence Code Pubs
located_in nuclear envelope IDA
Inferred from Direct Assay
more info
 PubMed 
located_in nucleus IDA
Inferred from Direct Assay
more info
 PubMed 
located_in nucleus IEA
Inferred from Electronic Annotation
more info
  

General protein information

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Preferred Names
Gcr2p
NP_014200.1
  • Transcriptional activator of genes involved in glycolysis; interacts and functions with the DNA-binding protein Gcr1p

NCBI Reference Sequences (RefSeq)

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Genome Annotation

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference assembly

Genomic

  1. NC_001146.8 Reference assembly

    Range
    264926..266530 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. NM_001183037.1 → NP_014200.1  TPA: Gcr2p [Saccharomyces cerevisiae S288C]

    See identical proteins and their annotated locations for NP_014200.1

    Status: REVIEWED

    UniProtKB/Swiss-Prot
    D6W0Y9, Q01722
    UniProtKB/TrEMBL
    A6ZRN9, C7GTG9, G2WLR2, N1NZ81
    Conserved Domains (1) summary
    PHA03255
    Location:30 → 131
    PHA03255; BDLF3; Provisional
Nucleotide Protein
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
Q01722.1

Gene LinkOut

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