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JJJ1 Jjj1p [ Saccharomyces cerevisiae S288C ]

Gene ID: 855495, updated on 3-Nov-2024

Summary

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Official Symbol
JJJ1
Official Full Name
Jjj1p
Primary source
SGD:S000005171
Locus tag
YNL227C
See related
AllianceGenome:SGD:S000005171; FungiDB:YNL227C; VEuPathDB:YNL227C
Gene type
protein coding
RefSeq status
REVIEWED
Organism
Saccharomyces cerevisiae S288C (strain: S288C)
Lineage
Eukaryota; Fungi; Dikarya; Ascomycota; Saccharomycotina; Saccharomycetes; Saccharomycetales; Saccharomycetaceae; Saccharomyces
Summary
Enables ATPase activator activity. Involved in endocytosis and ribosome biogenesis. Located in cytosol and nucleolus. Orthologous to human DNAJC21 (DnaJ heat shock protein family (Hsp40) member C21). [provided by Alliance of Genome Resources, Nov 2024]
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Genomic context

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See JJJ1 in Genome Data Viewer
Location:
chromosome: XIV
Exon count:
1
Sequence:
Chromosome: XIV; NC_001146.8 (220659..222431, complement)

Chromosome XIV - NC_001146.8Genomic Context describing neighboring genes Neighboring gene elongin A Neighboring gene glutathione peroxidase Neighboring gene Cnm67p Neighboring gene Sqs1p

Genomic regions, transcripts, and products

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Genomic Sequence:
NC_001146.8

Go to nucleotide: Graphics FASTA GenBank

Bibliography

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Related articles in PubMed

  1. A conserved domain important for association of eukaryotic J-protein co-chaperones Jjj1 and Zuo1 with the ribosome. Kaschner LA, et al. Biochim Biophys Acta, 2015 May. PMID 25639645, Free PMC Article
  2. Deletion of JJJ1 improves acetic acid tolerance and bioethanol fermentation performance of Saccharomyces cerevisiae strains. Wu X, et al. Biotechnol Lett, 2016 Jul. PMID 27067354
  3. The cytosolic J-protein, Jjj1, and Rei1 function in the removal of the pre-60 S subunit factor Arx1. Meyer AE, et al. J Biol Chem, 2010 Jan 8. PMID 19901025, Free PMC Article
  4. Dual interaction of the Hsp70 J-protein cochaperone Zuotin with the 40S and 60S ribosomal subunits. Lee K, et al. Nat Struct Mol Biol, 2016 Nov. PMID 27669034, Free PMC Article
  5. Cellular responses to proteostasis perturbations reveal non-optimal feedback in chaperone networks. Ghosh A, et al. Cell Mol Life Sci, 2019 Apr. PMID 30683983, Free PMC Article

See all (71) citations in PubMed

GeneRIFs: Gene References Into Functions

What's a GeneRIF?
  1. biochemically characterized ribosomal complexes of the yeast 60S-biogenesis factor Arx1 and late-maturation factors Rei1 and Jjj1 and determined their cryo-EM structures
    Title: Cryo-EM structures of Arx1 and maturation factors Rei1 and Jjj1 bound to the 60S ribosomal subunit.
  2. Jjj1 and Zuo1, function together with their partner Hsp70 proteins to mediate the biogenesis of ribosomes themselves. Jjj1 and Zuo1 have overlapping but distinct functions in this complex process
    Title: A ribosome-anchored chaperone network that facilitates eukaryotic ribosome biogenesis.
  3. both Rei1 and Jjj1 are required for dissociation of Arx1 from the pre-60 S subunit, and the region of Jjj1 that mediates interaction with Rei1 is required in vivo for 60 S subunit biogenesis
    Title: The cytosolic J-protein, Jjj1, and Rei1 function in the removal of the pre-60 S subunit factor Arx1.
  4. Preferentially required for the release of pre-ribosomal shuttling factors Arx1 and Alb1 from the cytoplasmic pre-60S particles.
    Title: The Hsp40 chaperone Jjj1 is required for the nucleo-cytoplasmic recycling of preribosomal factors in Saccharomyces cerevisiae.
  5. Jjj1, when overexpressed, is able to partially substitute for the Zuo1:Ssb chaperone machinery by recruiting Ssa to the ribosome, facilitating its interaction with nascent polypeptide chains
    Title: The specialized cytosolic J-protein, Jjj1, functions in 60S ribosomal subunit biogenesis.
Submit: New GeneRIF Correction

Interactions

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Products Interactant Other Gene Complex Source Pubs Description

General gene information

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Homology

Gene Ontology Provided by SGD

Function Evidence Code Pubs
enables ATPase activator activity IDA
Inferred from Direct Assay
more info
 PubMed 
enables metal ion binding IEA
Inferred from Electronic Annotation
more info
  
enables zinc ion binding RCA
inferred from Reviewed Computational Analysis
more info
 PubMed 
Process Evidence Code Pubs
involved_in endocytosis IMP
Inferred from Mutant Phenotype
more info
 PubMed 
involved_in rRNA processing IMP
Inferred from Mutant Phenotype
more info
 PubMed 
involved_in regulation of cell size HMP PubMed 
involved_in ribosomal large subunit biogenesis IMP
Inferred from Mutant Phenotype
more info
 PubMed 
involved_in ribosomal large subunit export from nucleus IMP
Inferred from Mutant Phenotype
more info
 PubMed 
Component Evidence Code Pubs
located_in cytoplasm HDA PubMed 
is_active_in cytoplasm IBA
Inferred from Biological aspect of Ancestor
more info
  
located_in cytoplasm IDA
Inferred from Direct Assay
more info
 PubMed 
located_in cytosol HDA PubMed 
located_in cytosol IDA
Inferred from Direct Assay
more info
 PubMed 
located_in mitochondrion HDA PubMed 
located_in nucleolus IMP
Inferred from Mutant Phenotype
more info
 PubMed 
located_in nucleus IEA
Inferred from Electronic Annotation
more info
  

General protein information

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Preferred Names
Jjj1p
NP_014172.1
  • Co-chaperone that stimulates the ATPase activity of Ssa1p; required for a late step of ribosome biogenesis; associated with the cytosolic large ribosomal subunit; contains a J-domain; mutation causes defects in fluid-phase endocytosis

NCBI Reference Sequences (RefSeq)

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Genome Annotation

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference assembly

Genomic

  1. NC_001146.8 Reference assembly

    Range
    220659..222431 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. NM_001183065.1 → NP_014172.1  TPA: Jjj1p [Saccharomyces cerevisiae S288C]

    See identical proteins and their annotated locations for NP_014172.1

    Status: REVIEWED

    UniProtKB/Swiss-Prot
    D6W0W4, P53863
    UniProtKB/TrEMBL
    B3LP69, C7GPD1, C8ZG07
    Conserved Domains (4) summary
    COG5269
    Location:6 → 275
    ZUO1; Ribosome-associated chaperone zuotin [Translation, ribosomal structure and biogenesis / Posttranslational modification, protein turnover, chaperones]
    PRK10767
    Location:1 → 67
    PRK10767; chaperone protein DnaJ; Provisional
    sd00020
    Location:340 → 362
    ZF_C2H2; C2H2 Zn finger [structural motif]
    pfam12171
    Location:338 → 363
    zf-C2H2_jaz; Zinc-finger double-stranded RNA-binding
Nucleotide Protein
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
P53863.1

Gene LinkOut

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