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BNI4 Bni4p [ Saccharomyces cerevisiae S288C ]

Gene ID: 855488, updated on 18-Sep-2024

Summary

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Official Symbol
BNI4
Official Full Name
Bni4p
Primary source
SGD:S000005177
Locus tag
YNL233W
See related
AllianceGenome:SGD:S000005177; FungiDB:YNL233W; VEuPathDB:YNL233W
Gene type
protein coding
RefSeq status
REVIEWED
Organism
Saccharomyces cerevisiae S288C (strain: S288C)
Lineage
Eukaryota; Fungi; Dikarya; Ascomycota; Saccharomycotina; Saccharomycetes; Saccharomycetales; Saccharomycetaceae; Saccharomyces
Summary
Predicted to enable actin binding activity. Involved in chitin biosynthetic process and division septum assembly. Located in cellular bud neck septin collar and septin ring. Part of incipient cellular bud site. Human ortholog(s) of this gene implicated in Parkinson's disease; developmental and epileptic encephalopathy 70; and multiple sclerosis. Orthologous to several human genes including PHACTR1 (phosphatase and actin regulator 1); PHACTR2 (phosphatase and actin regulator 2); and PHACTR3 (phosphatase and actin regulator 3). [provided by Alliance of Genome Resources, Apr 2022]
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Genomic context

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See BNI4 in Genome Data Viewer
Location:
chromosome: XIV
Exon count:
1
Sequence:
Chromosome: XIV; NC_001146.8 (211922..214600)

Chromosome XIV - NC_001146.8Genomic Context describing neighboring genes Neighboring gene Sin4p Neighboring gene uncharacterized protein Neighboring gene exosome non-catalytic core subunit CSL4 Neighboring gene phosphatidylinositol transporter

Genomic regions, transcripts, and products

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Genomic Sequence:
NC_001146.8

Go to nucleotide: Graphics FASTA GenBank

Bibliography

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Related articles in PubMed

  1. Changes in Bni4 localization induced by cell stress in Saccharomyces cerevisiae. Larson JR, et al. J Cell Sci, 2010 Apr 1. PMID 20197406, Free PMC Article
  2. Saccharomyces cerevisiae Bni4p directs the formation of the chitin ring and also participates in the correct assembly of the septum structure. Sanz M, et al. Microbiology (Reading), 2004 Oct. PMID 15470103
  3. Protein phosphatase type 1 directs chitin synthesis at the bud neck in Saccharomyces cerevisiae. Larson JR, et al. Mol Biol Cell, 2008 Jul. PMID 18480405, Free PMC Article
  4. Chitin synthase III requires Chs4p-dependent translocation of Chs3p into the plasma membrane. Reyes A, et al. J Cell Sci, 2007 Jun 15. PMID 17519287
  5. A Bni4-Glc7 phosphatase complex that recruits chitin synthase to the site of bud emergence. Kozubowski L, et al. Mol Biol Cell, 2003 Jan. PMID 12529424, Free PMC Article

See all (63) citations in PubMed

GeneRIFs: Gene References Into Functions

What's a GeneRIF?
  1. These results, together with a genetic correlation analysis, strongly support a functional model linking Slt2 MAP kinase and Pcl1, a Pho85 cyclin-dependent kinase, in septum assembly through Bni4.
    Title: Phosphorylation of Bni4 by MAP kinases contributes to septum assembly during yeast cytokinesis.
  2. Phosphorylation of Bni4 by Pcl-Pho85 is necessary for its localization to the bud neck, and the bud neck structure can be disrupted by overexpressing BNI4 in pcl1Deltapcl2Delta mutant cells.
    Title: Regulation of cell polarity through phosphorylation of Bni4 by Pho85 G1 cyclin-dependent kinases in Saccharomyces cerevisiae.
  3. the essential role of Bni4 is to target Glc7 to the neck and activate it toward substrates necessary for CSIII recruitment and synthesis of chitin at the bud neck
    Title: Protein phosphatase type 1 directs chitin synthesis at the bud neck in Saccharomyces cerevisiae.
Submit: New GeneRIF Correction

Interactions

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Products Interactant Other Gene Complex Source Pubs Description

General gene information

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Homology

Gene Ontology Provided by SGD

Function Evidence Code Pubs
enables actin binding IBA
Inferred from Biological aspect of Ancestor
more info
  
enables protein binding IPI
Inferred from Physical Interaction
more info
 PubMed 
Process Evidence Code Pubs
involved_in actin cytoskeleton organization IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in chitin biosynthetic process IMP
Inferred from Mutant Phenotype
more info
 PubMed 
involved_in division septum assembly IMP
Inferred from Mutant Phenotype
more info
 PubMed 
Component Evidence Code Pubs
located_in cellular bud neck IDA
Inferred from Direct Assay
more info
 PubMed 
located_in cellular bud neck septin collar IDA
Inferred from Direct Assay
more info
 PubMed 
located_in incipient cellular bud site IDA
Inferred from Direct Assay
more info
 PubMed 
located_in septin ring IDA
Inferred from Direct Assay
more info
 PubMed 

General protein information

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Preferred Names
Bni4p
NP_014166.1
  • Targeting subunit for Glc7p protein phosphatase; localized to the bud neck, required for localization of chitin synthase III to the bud neck via interaction with the chitin synthase III regulatory subunit Skt5p; phosphorylation by Slt2p and Kss1p involved in regulating Bni4p in septum assembly

NCBI Reference Sequences (RefSeq)

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Genome Annotation

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference assembly

Genomic

  1. NC_001146.8 Reference assembly

    Range
    211922..214600
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. NM_001183071.1 → NP_014166.1  TPA: Bni4p [Saccharomyces cerevisiae S288C]

    See identical proteins and their annotated locations for NP_014166.1

    Status: REVIEWED

    UniProtKB/Swiss-Prot
    D6W0V9, P53858
    UniProtKB/TrEMBL
    A6ZRK9, C7GPC6
Nucleotide Protein
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
P53858.1

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