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THI12 4-amino-5-hydroxymethyl-2-methylpyrimidine phosphate synthase [ Saccharomyces cerevisiae S288C ]

Gene ID: 855384, updated on 2-Nov-2024

Summary

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Official Symbol
THI12
Official Full Name
4-amino-5-hydroxymethyl-2-methylpyrimidine phosphate synthase
Primary source
SGD:S000005276
Locus tag
YNL332W
See related
AllianceGenome:SGD:S000005276; FungiDB:YNL332W; VEuPathDB:YNL332W
Gene type
protein coding
RefSeq status
REVIEWED
Organism
Saccharomyces cerevisiae S288C (strain: S288C)
Lineage
Eukaryota; Fungi; Dikarya; Ascomycota; Saccharomycotina; Saccharomycetes; Saccharomycetales; Saccharomycetaceae; Saccharomyces
Summary
Predicted to enable metal ion binding activity and transferase activity. Involved in thiamine biosynthetic process. [provided by Alliance of Genome Resources, Nov 2024]
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Genomic context

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See THI12 in Genome Data Viewer
Location:
chromosome: XIV
Exon count:
1
Sequence:
Chromosome: XIV; NC_001146.8 (14832..15854)

Chromosome XIV - NC_001146.8Genomic Context describing neighboring genes Neighboring gene putative pyridoxal 5'-phosphate synthase Neighboring gene pyridoxine biosynthesis protein SNZ2 Neighboring gene putative aryl-alcohol dehydrogenase Neighboring gene histone deacetylase RPD3

Genomic regions, transcripts, and products

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Genomic Sequence:
NC_001146.8

Go to nucleotide: Graphics FASTA GenBank

Bibliography

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Related articles in PubMed

  1. Genetic interaction network of the Saccharomyces cerevisiae type 1 phosphatase Glc7. Logan MR, et al. BMC Genomics, 2008 Jul 15. PMID 18627629, Free PMC Article
  2. The nucleotide sequence of Saccharomyces cerevisiae chromosome XIV and its evolutionary implications. Philippsen P, et al. Nature, 1997 May 29. PMID 9169873
  3. Saccharomyces cerevisiae genetics predicts candidate therapeutic genetic interactions at the mammalian replication fork. van Pel DM, et al. G3 (Bethesda), 2013 Feb. PMID 23390603, Free PMC Article
  4. Functional Metabolomics Describes the Yeast Biosynthetic Regulome. Mülleder M, et al. Cell, 2016 Oct 6. PMID 27693354, Free PMC Article
  5. The THI5 gene family of Saccharomyces cerevisiae: distribution of homologues among the hemiascomycetes and functional redundancy in the aerobic biosynthesis of thiamin from pyridoxine. Wightman R, et al. Microbiology (Reading), 2003 Jun. PMID 12777485

See all (9) citations in PubMed

GeneRIFs: Gene References Into Functions

Pathways from PubChem

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Interactions

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Products Interactant Other Gene Complex Source Pubs Description

General gene information

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Homology

Gene Ontology Provided by SGD

Function Evidence Code Pubs
enables metal ion binding IEA
Inferred from Electronic Annotation
more info
  
enables molecular_function ND
No biological Data available
more info
  
enables transferase activity IEA
Inferred from Electronic Annotation
more info
  
Process Evidence Code Pubs
involved_in thiamine biosynthetic process IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in thiamine biosynthetic process IEA
Inferred from Electronic Annotation
more info
  
involved_in thiamine biosynthetic process IGI
Inferred from Genetic Interaction
more info
 PubMed 
involved_in thiamine diphosphate biosynthetic process IEA
Inferred from Electronic Annotation
more info
  
Component Evidence Code Pubs
is_active_in cellular_component ND
No biological Data available
more info
  

General protein information

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Preferred Names
4-amino-5-hydroxymethyl-2-methylpyrimidine phosphate synthase
NP_014067.1
  • Protein involved in synthesis of the thiamine precursor HMP; member of a subtelomeric gene family including THI5, THI11, THI12, and THI13; hydroxymethylpyrimidine is also known as HMP

NCBI Reference Sequences (RefSeq)

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Genome Annotation

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference assembly

Genomic

  1. NC_001146.8 Reference assembly

    Range
    14832..15854
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. NM_001183170.1 → NP_014067.1  TPA: 4-amino-5-hydroxymethyl-2-methylpyrimidine phosphate synthase [Saccharomyces cerevisiae S288C]

    See identical proteins and their annotated locations for NP_014067.1

    Status: REVIEWED

    UniProtKB/Swiss-Prot
    D6W0L5, P42883
    UniProtKB/TrEMBL
    C8ZGJ3
    Conserved Domains (1) summary
    cd13650
    Location:5 → 255
    PBP2_THI5; Substrate binding domain of ABC-type transporters for thiamin biosynthetic pathway intermediates; a member of the type 2 periplasmic binding fold superfamily
Nucleotide Protein
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
P42883.1

Gene LinkOut

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