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TRS130 transport protein particle complex II subunit TRS130 [ Saccharomyces cerevisiae S288C ]

Gene ID: 855258, updated on 28-Oct-2024

Summary

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Official Symbol
TRS130
Official Full Name
transport protein particle complex II subunit TRS130
Primary source
SGD:S000004831
Locus tag
YMR218C
See related
AllianceGenome:SGD:S000004831; FungiDB:YMR218C; VEuPathDB:YMR218C
Gene type
protein coding
RefSeq status
REVIEWED
Organism
Saccharomyces cerevisiae S288C (strain: S288C)
Lineage
Eukaryota; Fungi; Dikarya; Ascomycota; Saccharomycotina; Saccharomycetes; Saccharomycetales; Saccharomycetaceae; Saccharomyces
Summary
Contributes to guanyl-nucleotide exchange factor activity. Involved in Golgi vesicle transport; cytoplasm to vacuole targeting by the Cvt pathway; and macroautophagy. Located in early endosome and trans-Golgi network. Part of TRAPPII protein complex. Orthologous to human TRAPPC10 (trafficking protein particle complex subunit 10). [provided by Alliance of Genome Resources, Oct 2024]
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Genomic context

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See TRS130 in Genome Data Viewer
Location:
chromosome: XIII
Exon count:
1
Sequence:
Chromosome: XIII; NC_001145.3 (703579..706887, complement)

Chromosome XIII - NC_001145.3Genomic Context describing neighboring genes Neighboring gene serine/threonine protein kinase SKY1 Neighboring gene GMP synthase (glutamine-hydrolyzing) Neighboring gene Esc1p Neighboring gene phosphomevalonate kinase

Genomic regions, transcripts, and products

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Genomic Sequence:
NC_001145.3

Go to nucleotide: Graphics FASTA GenBank

Bibliography

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Related articles in PubMed

  1. Mutants in trs120 disrupt traffic from the early endosome to the late Golgi. Cai H, et al. J Cell Biol, 2005 Dec 5. PMID 16314430, Free PMC Article
  2. Bi-allelic mutations in TRAPPC2L result in a neurodevelopmental disorder and have an impact on RAB11 in fibroblasts. Milev MP, et al. J Med Genet, 2018 Nov. PMID 30120216
  3. Conservation of the TRAPPII-specific subunits of a Ypt/Rab exchanger complex. Cox R, et al. BMC Evol Biol, 2007 Feb 2. PMID 17274825, Free PMC Article
  4. Mutation of TRS130, which encodes a component of the TRAPP II complex, activates transcription of OCH1 in Saccharomyces cerevisiae. Yamamoto K, et al. Curr Genet, 2002 Nov. PMID 12478387
  5. Modular TRAPP complexes regulate intracellular protein trafficking through multiple Ypt/Rab GTPases in Saccharomyces cerevisiae. Zou S, et al. Genetics, 2012 Jun. PMID 22426882, Free PMC Article

See all (51) citations in PubMed

GeneRIFs: Gene References Into Functions

What's a GeneRIF?
  1. Trs130 mutants do not transport Atg8 and Atg9 to the pre-autophagosomal structure/phagophore assembly site.
    Title: Trs130 participates in autophagy through GTPases Ypt31/32 in Saccharomyces cerevisiae.
Submit: New GeneRIF Correction

Pathways from PubChem

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Interactions

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Products Interactant Other Gene Complex Source Pubs Description

General gene information

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Homology

Gene Ontology Provided by SGD

Function Evidence Code Pubs
contributes_to guanyl-nucleotide exchange factor activity IGI
Inferred from Genetic Interaction
more info
 PubMed 
contributes_to guanyl-nucleotide exchange factor activity IMP
Inferred from Mutant Phenotype
more info
 PubMed 
contributes_to guanyl-nucleotide exchange factor activity IPI
Inferred from Physical Interaction
more info
 PubMed 
Process Evidence Code Pubs
involved_in Golgi vesicle transport IEA
Inferred from Electronic Annotation
more info
  
involved_in autophagy IEA
Inferred from Electronic Annotation
more info
  
involved_in cytoplasm to vacuole targeting by the Cvt pathway IMP
Inferred from Mutant Phenotype
more info
 PubMed 
involved_in early endosome to Golgi transport IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in early endosome to Golgi transport IMP
Inferred from Mutant Phenotype
more info
 PubMed 
involved_in intra-Golgi vesicle-mediated transport IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in intra-Golgi vesicle-mediated transport IMP
Inferred from Mutant Phenotype
more info
 PubMed 
involved_in macroautophagy IMP
Inferred from Mutant Phenotype
more info
 PubMed 
Component Evidence Code Pubs
located_in Golgi apparatus IEA
Inferred from Electronic Annotation
more info
  
part_of TRAPPII protein complex IBA
Inferred from Biological aspect of Ancestor
more info
  
part_of TRAPPII protein complex IDA
Inferred from Direct Assay
more info
 PubMed 
part_of TRAPPII protein complex IEA
Inferred from Electronic Annotation
more info
  
located_in cytosol IEA
Inferred from Electronic Annotation
more info
  
located_in early endosome IDA
Inferred from Direct Assay
more info
 PubMed 
located_in trans-Golgi network IDA
Inferred from Direct Assay
more info
 PubMed 

General protein information

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Preferred Names
transport protein particle complex II subunit TRS130
NP_013945.1
  • Component of transport protein particle (TRAPP) complex II; TRAPPII is a multimeric guanine nucleotide-exchange factor for the GTPase Ypt1p, regulating intra-Golgi and endosome-Golgi traffic

NCBI Reference Sequences (RefSeq)

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Genome Annotation

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference assembly

Genomic

  1. NC_001145.3 Reference assembly

    Range
    703579..706887 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. NM_001182725.1 → NP_013945.1  TPA: transport protein particle complex II subunit TRS130 [Saccharomyces cerevisiae S288C]

    See identical proteins and their annotated locations for NP_013945.1

    Status: REVIEWED

    UniProtKB/Swiss-Prot
    D6W043, Q03660
    UniProtKB/TrEMBL
    B5VPY5
    Conserved Domains (1) summary
    pfam12584
    Location:1003 → 1101
    TRAPPC10; Trafficking protein particle complex subunit 10, TRAPPC10
Nucleotide Protein
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
Q03660.1

Gene LinkOut

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