RAD14 DNA repair protein RAD14 [Saccharomyces cerevisiae S288C] - Gene

Summary

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Official Symbol: RAD14
Official Full Name: DNA repair protein RAD14
Primary source: SGD:S000004814
Locus tag: YMR201C
See related: AllianceGenome:SGD:S000004814; FungiDB:YMR201C; VEuPathDB:YMR201C
Gene type: protein coding
RefSeq status: REVIEWED
Organism: Saccharomyces cerevisiae S288C (strain: S288C)
Lineage: Eukaryota; Fungi; Dikarya; Ascomycota; Saccharomycotina; Saccharomycetes; Saccharomycetales; Saccharomycetaceae; Saccharomyces
Summary: Enables damaged DNA binding activity and zinc ion binding activity. Involved in nucleotide-excision repair, DNA damage recognition. Located in nucleus. Part of nucleotide-excision repair factor 1 complex. Used to study xeroderma pigmentosum group A. Human ortholog(s) of this gene implicated in xeroderma pigmentosum and xeroderma pigmentosum group A. Orthologous to human XPA (XPA, DNA damage recognition and repair factor). [provided by Alliance of Genome Resources, Nov 2024]
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Genomic context

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See RAD14 in Genome Data Viewer

Location:: chromosome: XIII

Exon count:: 2

Sequence:: Chromosome: XIII; NC_001145.3 (665845..667044, complement)

Chromosome XIII - NC_001145.3 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Go to reference sequence details

Genomic Sequence:: NC_001145.3

Go to nucleotide: Graphics FASTA GenBank

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Data indicate that two DNA repair enzyme Rad14 molecules bind to the duplex, which induces DNA melting of the duplex remote from the lesion.
Title: Structural insights into the recognition of cisplatin and AAF-dG lesion by Rad14 (XPA).
results unveil a new role of Rad14p in stimulating transcription in addition to its well-known function in nucleotide excision repair
Title: Functional analysis of Rad14p, a DNA damage recognition factor in nucleotide excision repair, in regulation of transcription in vivo.
yeast Nucleotide Excision Repair protein assembly is step-wise whereas Rad14 required to recruit Rad10 and Rad14 involvement is transient
Title: Rad10-YFP focus induction in response to UV depends on RAD14 in yeast.
The ability of Rad1-Rad10 nuclease to associate in a complex with Rad14 is paramount for the targeting of this nuclease to lesion sites in vivo.
Title: Complex formation with damage recognition protein Rad14 is essential for Saccharomyces cerevisiae Rad1-Rad10 nuclease to perform its function in nucleotide excision repair in vivo.

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Pathways from PubChem

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Interactions

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Products	Interactant	Other Gene	Complex	Source	Pubs	Description

General gene information

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Homology

Orthologs from OrthoDB

Gene Ontology Provided by SGD

Function	Evidence Code	Pubs
enables DNA binding	IEA Inferred from Electronic Annotation more info
enables damaged DNA binding	IBA Inferred from Biological aspect of Ancestor more info
enables damaged DNA binding	IDA Inferred from Direct Assay more info	PubMed
enables damaged DNA binding	IEA Inferred from Electronic Annotation more info
enables metal ion binding	IEA Inferred from Electronic Annotation more info
enables zinc ion binding	IDA Inferred from Direct Assay more info	PubMed
enables zinc ion binding	RCA inferred from Reviewed Computational Analysis more info	PubMed

Process	Evidence Code	Pubs
involved_in DNA damage response	IDA Inferred from Direct Assay more info	PubMed
involved_in DNA repair	IEA Inferred from Electronic Annotation more info
involved_in UV-damage excision repair	IBA Inferred from Biological aspect of Ancestor more info
involved_in base-excision repair	IBA Inferred from Biological aspect of Ancestor more info
involved_in nucleotide-excision repair	IEA Inferred from Electronic Annotation more info
involved_in nucleotide-excision repair involved in interstrand cross-link repair	IBA Inferred from Biological aspect of Ancestor more info
involved_in nucleotide-excision repair, DNA damage recognition	IBA Inferred from Biological aspect of Ancestor more info
involved_in nucleotide-excision repair, DNA damage recognition	IDA Inferred from Direct Assay more info	PubMed

Component	Evidence Code	Pubs
part_of nucleotide-excision repair factor 1 complex	IBA Inferred from Biological aspect of Ancestor more info
part_of nucleotide-excision repair factor 1 complex	IPI Inferred from Physical Interaction more info	PubMed
located_in nucleus	IDA Inferred from Direct Assay more info	PubMed
located_in nucleus	IEA Inferred from Electronic Annotation more info

General protein information

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Preferred Names: DNA repair protein RAD14

NP_013928.1

Subunit of Nucleotide Excision Repair Factor 1 (NEF1); recognizes and binds damaged DNA during nucleotide excision repair (NER); also involved in regulation of transcription; contains zinc finger motif; homolog of human XPA protein

NCBI Reference Sequences (RefSeq)

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Genome Annotation

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference assembly

Genomic

NC_001145.3 Reference assembly

Range

665845..667044 complement

Download

GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

NM_001182708.1 → NP_013928.1 TPA: DNA repair protein RAD14 [Saccharomyces cerevisiae S288C]

See identical proteins and their annotated locations for NP_013928.1

Status: REVIEWED

UniProtKB/Swiss-Prot

D6W026, P28519

UniProtKB/TrEMBL

A6ZMR3, B3LM89, C7GRF0, C8ZF66, G2WKQ7, N1NYL2

Conserved Domains (1) summary

COG5145
Location:20 → 371

RAD14; DNA excision repair protein [DNA replication, recombination, and repair]