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RTP1 Rtp1p [ Saccharomyces cerevisiae S288C ]

Gene ID: 855223, updated on 2-Nov-2024

Summary

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Official Symbol
RTP1
Official Full Name
Rtp1p
Primary source
SGD:S000004797
Locus tag
YMR185W
See related
AllianceGenome:SGD:S000004797; FungiDB:YMR185W; VEuPathDB:YMR185W
Gene type
protein coding
RefSeq status
REVIEWED
Organism
Saccharomyces cerevisiae S288C (strain: S288C)
Lineage
Eukaryota; Fungi; Dikarya; Ascomycota; Saccharomycotina; Saccharomycetes; Saccharomycetales; Saccharomycetaceae; Saccharomyces
Summary
Involved in protein import into nucleus. Located in cytoplasm. Orthologous to human TANGO6 (transport and golgi organization 6 homolog). [provided by Alliance of Genome Resources, Nov 2024]
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Genomic context

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See RTP1 in Genome Data Viewer
Location:
chromosome: XIII
Exon count:
1
Sequence:
Chromosome: XIII; NC_001145.3 (629025..631970)

Chromosome XIII - NC_001145.3Genomic Context describing neighboring genes Neighboring gene syntaxin Neighboring gene Add37p Neighboring gene Hsp90 family chaperone HSC82 Neighboring gene uncharacterized protein

Genomic regions, transcripts, and products

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Genomic Sequence:
NC_001145.3

Go to nucleotide: Graphics FASTA GenBank

Bibliography

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Related articles in PubMed

  1. Comprehensive and quantitative analysis of yeast deletion mutants defective in apical and isotropic bud growth. Watanabe M, et al. Curr Genet, 2009 Aug. PMID 19466415
  2. Different pathways for the nuclear import of yeast RNA polymerase II. Gómez-Navarro N, et al. Biochim Biophys Acta, 2015 Nov. PMID 26455955
  3. Rtp1p is a karyopherin-like protein required for RNA polymerase II biogenesis. Gómez-Navarro N, et al. Mol Cell Biol, 2013 May. PMID 23438601, Free PMC Article
  4. Large-scale functional genomic analysis of sporulation and meiosis in Saccharomyces cerevisiae. Enyenihi AH, et al. Genetics, 2003 Jan. PMID 12586695, Free PMC Article
  5. Essential histone chaperones collaborate to regulate transcription and chromatin integrity. Viktorovskaya O, et al. Genes Dev, 2021 May 1. PMID 33888559, Free PMC Article

See all (22) citations in PubMed

GeneRIFs: Gene References Into Functions

Interactions

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Products Interactant Other Gene Complex Source Pubs Description

General gene information

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Homology

Gene Ontology Provided by SGD

Function Evidence Code Pubs
enables molecular_function ND
No biological Data available
more info
  
Process Evidence Code Pubs
involved_in protein import into nucleus IMP
Inferred from Mutant Phenotype
more info
 PubMed 
involved_in protein secretion IBA
Inferred from Biological aspect of Ancestor
more info
  
Component Evidence Code Pubs
located_in cytoplasm IDA
Inferred from Direct Assay
more info
 PubMed 
located_in cytoplasm IEA
Inferred from Electronic Annotation
more info
  

General protein information

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Preferred Names
Rtp1p
NP_013910.1
  • Protein required for the nuclear import and biogenesis of RNA pol II; conflicting evidence on whether null mutant is viable with elongated buds, or inviable; interacts with Rpb2, Rpb3, Nup116p, Nup100p and components of the R2TP complex (Rvb1p, Rvb2p, Pih1p); similar to human TMCO7 gene

NCBI Reference Sequences (RefSeq)

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Genome Annotation

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference assembly

Genomic

  1. NC_001145.3 Reference assembly

    Range
    629025..631970
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. NM_001182691.1 → NP_013910.1  TPA: Rtp1p [Saccharomyces cerevisiae S288C]

    See identical proteins and their annotated locations for NP_013910.1

    Status: REVIEWED

    UniProtKB/Swiss-Prot
    D6W009, Q12751
    UniProtKB/TrEMBL
    C7GTR5, N1P5R4
    Conserved Domains (2) summary
    pfam10304
    Location:947 → 979
    RTP1_C2; Required for nuclear transport of RNA pol II C-terminus 2
    pfam10363
    Location:735 → 840
    RTP1_C1; Required for nuclear transport of RNA pol II C-terminus 1
Nucleotide Protein
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
Q12751.1

Gene LinkOut

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