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RIM11 serine/threonine protein kinase RIM11 [ Saccharomyces cerevisiae S288C ]

Gene ID: 855170, updated on 28-Oct-2024

Summary

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Official Symbol
RIM11
Official Full Name
serine/threonine protein kinase RIM11
Primary source
SGD:S000004747
Locus tag
YMR139W
See related
AllianceGenome:SGD:S000004747; FungiDB:YMR139W; VEuPathDB:YMR139W
Gene type
protein coding
RefSeq status
REVIEWED
Organism
Saccharomyces cerevisiae S288C (strain: S288C)
Lineage
Eukaryota; Fungi; Dikarya; Ascomycota; Saccharomycotina; Saccharomycetes; Saccharomycetales; Saccharomycetaceae; Saccharomyces
Also known as
GSK3; MDS1
Summary
Enables protein serine/threonine kinase activity. Involved in ascospore formation. Located in cytoplasm. Human ortholog(s) of this gene implicated in Alzheimer's disease; amyotrophic lateral sclerosis; bipolar disorder; oral squamous cell carcinoma; and schizophrenia. Orthologous to human GSK3A (glycogen synthase kinase 3 alpha) and GSK3B (glycogen synthase kinase 3 beta). [provided by Alliance of Genome Resources, Oct 2024]
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Genomic context

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See RIM11 in Genome Data Viewer
Location:
chromosome: XIII
Exon count:
1
Sequence:
Chromosome: XIII; NC_001145.3 (546125..547237)

Chromosome XIII - NC_001145.3Genomic Context describing neighboring genes Neighboring gene DNA cross-link repair protein PSO2 Neighboring gene Arf family GTPase CIN4 Neighboring gene Sip5p Neighboring gene uncharacterized protein

Genomic regions, transcripts, and products

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Genomic Sequence:
NC_001145.3

Go to nucleotide: Graphics FASTA GenBank

Bibliography

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Related articles in PubMed

  1. A powerful yeast model to investigate the synergistic interaction of α-synuclein and tau in neurodegeneration. Ciaccioli G, et al. PLoS One, 2013. PMID 23393603, Free PMC Article
  2. Glycogen synthase kinase-3 is required for optimal de novo synthesis of inositol. Azab AN, et al. Mol Microbiol, 2007 Feb. PMID 17257308
  3. Genetic evidence for transcriptional activation by the yeast IME1 gene product. Smith HE, et al. Genetics, 1993 Apr. PMID 8462841, Free PMC Article
  4. Novel Saccharomyces cerevisiae gene, MRK1, encoding a putative protein kinase with similarity to mammalian glycogen synthase kinase-3 and Drosophila Zeste-White3/Shaggy. Hardy TA, et al. Biochem Biophys Res Commun, 1995 Mar 17. PMID 7695629
  5. The in vivo activity of Ime1, the key transcriptional activator of meiosis-specific genes in Saccharomyces cerevisiae, is inhibited by the cyclic AMP/protein kinase A signal pathway through the glycogen synthase kinase 3-beta homolog Rim11. Rubin-Bejerano I, et al. Mol Cell Biol, 2004 Aug. PMID 15282298, Free PMC Article

See all (82) citations in PubMed

GeneRIFs: Gene References Into Functions

What's a GeneRIF?
  1. Multi-signal regulation of the GSK-3beta homolog Rim11 controls meiosis entry in budding yeast.
    Title: Multi-signal regulation of the GSK-3β homolog Rim11 controls meiosis entry in budding yeast.
  2. Yeast Rim11 kinase responds to glutathione-induced stress by regulating the transcription of phospholipid biosynthetic genes.
    Title: Yeast Rim11 kinase responds to glutathione-induced stress by regulating the transcription of phospholipid biosynthetic genes.
  3. Glycogen synthase kinase homolog Rim11 regulates lipid synthesis through the phosphorylation of Pah1 phosphatidate phosphatase in yeast.
    Title: Glycogen synthase kinase homolog Rim11 regulates lipid synthesis through the phosphorylation of Pah1 phosphatidate phosphatase in yeast.
  4. We also present evidence that indicates Rim11/Ume6 works independently but in parallel with that of checkpoint inhibition, dNTP regulation, and sister-chromatid recombination. In conclusion, our results establish Rim11, Ume6, the histone deacetylase complex Sin3-Rpd3 and Sml1 as new factors important in the events of faulty lagging strand synthesis.
    Title: GSK-3β Homolog Rim11 and the Histone Deacetylase Complex Ume6-Sin3-Rpd3 Are Involved in Replication Stress Response Caused by Defects in Dna2.
  5. Yeast GSK-3 kinase regulates astral microtubule function through phosphorylation of the microtubule-stabilizing kinesin Kip2
    Title: Yeast GSK-3 kinase regulates astral microtubule function through phosphorylation of the microtubule-stabilizing kinesin Kip2.
  6. This review summarizes the cellular roles of four homologs of GSK-3beta, RIM11, MCK1, MRK1 and YGK3, their mode of regulation, and the signals that they transmit.
    Title: The Saccharomyces cerevisiae GSK-3 beta homologs.
  7. GSK-3 is required for optimal myo-inositol-3 phosphate synthase activity and de novo inositol biosynthesis
    Title: Glycogen synthase kinase-3 is required for optimal de novo synthesis of inositol.
Submit: New GeneRIF Correction

Pathways from PubChem

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Interactions

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Products Interactant Other Gene Complex Source Pubs Description

General gene information

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Homology

Gene Ontology Provided by SGD

Function Evidence Code Pubs
enables ATP binding IEA
Inferred from Electronic Annotation
more info
  
enables histone H2AS1 kinase activity IEA
Inferred from Electronic Annotation
more info
  
enables protein kinase activity HDA PubMed 
enables protein kinase activity IEA
Inferred from Electronic Annotation
more info
  
enables protein serine kinase activity IEA
Inferred from Electronic Annotation
more info
  
enables protein serine/threonine kinase activity IBA
Inferred from Biological aspect of Ancestor
more info
  
enables protein serine/threonine kinase activity IDA
Inferred from Direct Assay
more info
 PubMed 
enables protein serine/threonine kinase activity IEA
Inferred from Electronic Annotation
more info
  
enables protein serine/threonine/tyrosine kinase activity IBA
Inferred from Biological aspect of Ancestor
more info
  
Process Evidence Code Pubs
involved_in ascospore formation IMP
Inferred from Mutant Phenotype
more info
 PubMed 
involved_in cell differentiation IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in chromatin remodeling IEA
Inferred from Electronic Annotation
more info
  
involved_in phosphorylation IEA
Inferred from Electronic Annotation
more info
  
involved_in protein phosphorylation IEA
Inferred from Electronic Annotation
more info
  
involved_in signal transduction IBA
Inferred from Biological aspect of Ancestor
more info
  
Component Evidence Code Pubs
located_in cytoplasm HDA PubMed 
is_active_in cytoplasm IBA
Inferred from Biological aspect of Ancestor
more info
  
is_active_in nucleus IBA
Inferred from Biological aspect of Ancestor
more info
  

General protein information

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Preferred Names
serine/threonine protein kinase RIM11
NP_013859.1
  • Protein kinase; required for signal transduction during entry into meiosis; promotes the formation of the Ime1p-Ume6p complex by phosphorylating Ime1p and Ume6p; shares similarity with mammalian glycogen synthase kinase 3-beta; protein abundance increases in response to DNA replication stress; RIM11 has a paralog, MRK1, that arose from the whole genome duplication

NCBI Reference Sequences (RefSeq)

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Genome Annotation

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference assembly

Genomic

  1. NC_001145.3 Reference assembly

    Range
    546125..547237
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. NM_001182641.1 → NP_013859.1  TPA: serine/threonine protein kinase RIM11 [Saccharomyces cerevisiae S288C]

    See identical proteins and their annotated locations for NP_013859.1

    Status: REVIEWED

    UniProtKB/Swiss-Prot
    D6VZW2, P38615, Q6Q5K4
    UniProtKB/TrEMBL
    A6ZMJ9, B3LM27, C7GU79, C8ZEZ5, G2WKJ1
    Conserved Domains (1) summary
    cd14137
    Location:34 → 325
    STKc_GSK3; The catalytic domain of the Serine/Threonine Kinase, Glycogen Synthase Kinase 3
Nucleotide Protein
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
P38615.1

Gene LinkOut

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