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AAC1 ADP/ATP carrier protein AAC1 [ Saccharomyces cerevisiae S288C ]

Gene ID: 855078, updated on 14-Nov-2024

Summary

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Official Symbol
AAC1
Official Full Name
ADP/ATP carrier protein AAC1
Primary source
SGD:S000004660
Locus tag
YMR056C
See related
AllianceGenome:SGD:S000004660; FungiDB:YMR056C; VEuPathDB:YMR056C
Gene type
protein coding
RefSeq status
REVIEWED
Organism
Saccharomyces cerevisiae S288C (strain: S288C)
Lineage
Eukaryota; Fungi; Dikarya; Ascomycota; Saccharomycotina; Saccharomycetes; Saccharomycetales; Saccharomycetaceae; Saccharomyces
Summary
Enables ATP:ADP antiporter activity. Involved in several processes, including aerobic respiration; heme biosynthetic process; and heme transport. Located in mitochondrial inner membrane. Human ortholog(s) of this gene implicated in intrinsic cardiomyopathy (multiple); mitochondrial DNA depletion syndrome (multiple); and mitochondrial myopathy (multiple). Orthologous to several human genes including SLC25A4 (solute carrier family 25 member 4) and SLC25A5 (solute carrier family 25 member 5). [provided by Alliance of Genome Resources, Nov 2024]
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Genomic context

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See AAC1 in Genome Data Viewer
Location:
chromosome: XIII
Exon count:
1
Sequence:
Chromosome: XIII; NC_001145.3 (387315..388244, complement)

Chromosome XIII - NC_001145.3Genomic Context describing neighboring genes Neighboring gene H(+)-transporting V0 sector ATPase subunit a Neighboring gene Bub2p Neighboring gene ferroxidase FET3 Neighboring gene Sen15p

Genomic regions, transcripts, and products

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Genomic Sequence:
NC_001145.3

Go to nucleotide: Graphics FASTA GenBank

Bibliography

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Related articles in PubMed

  1. The delivery of ADP/ATP carrier protein to mitochondria probed by fusions with green fluorescent protein and beta-galactosidase. Polcicová K, et al. FEMS Yeast Res, 2003 Dec. PMID 14654436
  2. A Klaac null mutant of Kluyveromyces lactis is complemented by a single copy of the Saccharomyces cerevisiae AAC1 gene. Viola AM, et al. Curr Genet, 1999 Aug. PMID 10447592
  3. Difference between yeast and bovine mitochondrial ADP/ATP carriers in terms of conformational properties of the first matrix loop as deduced by use of copper-o-phenanthroline. Kihira Y, et al. Biol Pharm Bull, 2007 May. PMID 17473430
  4. A cryptic matrix targeting signal of the yeast ADP/ATP carrier normally inserted by the TIM22 complex is recognized by the TIM23 machinery. Vergnolle MA, et al. Biochem J, 2005 Jan 1. PMID 15320873, Free PMC Article
  5. Structure-function studies of adenine nucleotide transport in mitochondria. I. Construction and genetic analysis of yeast mutants encoding the ADP/ATP carrier protein of mitochondria. Lawson JE, et al. J Biol Chem, 1990 Aug 25. PMID 2167308

See all (76) citations in PubMed

GeneRIFs: Gene References Into Functions

What's a GeneRIF?
  1. all Cys residues that replaced 9 continuous amino acids in Met310-Lys318 showed high reactivity with eosin 5-maleimde regardless of presence of carboxyatractyloside or bongkrekate; this region was concluded to be exposed to water-accessible environment.
    Title: Functionally important conserved length of C-terminal regions of yeast and bovine ADP/ATP carriers, identified by deletion mutants studies, and water accessibility of the amino acids at the C-terminal region of the yeast carrier.
  2. AAC contains a cryptic matrix targeting signal that can target up to two thirds of the N-terminal part of the protein to the matrix, and this event is coordinated by the TIM23 translocase
    Title: A cryptic matrix targeting signal of the yeast ADP/ATP carrier normally inserted by the TIM22 complex is recognized by the TIM23 machinery.
Submit: New GeneRIF Correction

Interactions

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Products Interactant Other Gene Complex Source Pubs Description

General gene information

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Homology

Gene Ontology Provided by SGD

Function Evidence Code Pubs
enables ATP:ADP antiporter activity IDA
Inferred from Direct Assay
more info
 PubMed 
enables ATP:ADP antiporter activity IEA
Inferred from Electronic Annotation
more info
  
enables antiporter activity IEA
Inferred from Electronic Annotation
more info
  
Process Evidence Code Pubs
involved_in aerobic respiration IGI
Inferred from Genetic Interaction
more info
 PubMed 
involved_in heme biosynthetic process IGI
Inferred from Genetic Interaction
more info
 PubMed 
involved_in heme transport IMP
Inferred from Mutant Phenotype
more info
 PubMed 
involved_in mitochondrial ADP transmembrane transport IEA
Inferred from Electronic Annotation
more info
  
involved_in mitochondrial ATP transmembrane transport IEA
Inferred from Electronic Annotation
more info
  
involved_in mitochondrial transport IGI
Inferred from Genetic Interaction
more info
 PubMed 
Component Evidence Code Pubs
located_in mitochondrial inner membrane IDA
Inferred from Direct Assay
more info
 PubMed 
located_in mitochondrial inner membrane IEA
Inferred from Electronic Annotation
more info
  
located_in mitochondrion HDA PubMed 
located_in mitochondrion IEA
Inferred from Electronic Annotation
more info
  

General protein information

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Preferred Names
ADP/ATP carrier protein AAC1
NP_013772.1
  • Mitochondrial inner membrane ADP/ATP translocator; exchanges cytosolic ADP for mitochondrially synthesized ATP; phosphorylated; Aac1p is a minor isoform while Pet9p is the major ADP/ATP translocator; relocalizes from mitochondrion to cytoplasm upon DNA replication stress

NCBI Reference Sequences (RefSeq)

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Genome Annotation

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference assembly

Genomic

  1. NC_001145.3 Reference assembly

    Range
    387315..388244 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. NM_001182554.1 → NP_013772.1  TPA: ADP/ATP carrier protein AAC1 [Saccharomyces cerevisiae S288C]

    See identical proteins and their annotated locations for NP_013772.1

    Status: REVIEWED

    UniProtKB/Swiss-Prot
    D6VZN1, P04710
    UniProtKB/TrEMBL
    A6ZMB6, B3LLV0, B5VPI5, C7GL67, C8ZEQ9, G2WKA5
    Conserved Domains (1) summary
    PTZ00169
    Location:9 → 303
    PTZ00169; ADP/ATP transporter on adenylate translocase; Provisional
Nucleotide Protein
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
P04710.1

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