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ADI1 acireductone dioxygenase (Ni2+-requiring) [ Saccharomyces cerevisiae S288C ]

Gene ID: 855021, updated on 2-Nov-2024

Summary

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Official Symbol
ADI1
Official Full Name
acireductone dioxygenase (Ni2+-requiring)
Primary source
SGD:S000004611
Locus tag
YMR009W
See related
AllianceGenome:SGD:S000004611; FungiDB:YMR009W; VEuPathDB:YMR009W
Gene type
protein coding
RefSeq status
REVIEWED
Organism
Saccharomyces cerevisiae S288C (strain: S288C)
Lineage
Eukaryota; Fungi; Dikarya; Ascomycota; Saccharomycotina; Saccharomycetes; Saccharomycetales; Saccharomycetaceae; Saccharomyces
Summary
Enables acireductone dioxygenase (Ni2+-requiring) activity. Involved in L-methionine salvage from methylthioadenosine. Located in cytoplasm and nucleus. Orthologous to human ADI1 (acireductone dioxygenase 1). [provided by Alliance of Genome Resources, Nov 2024]
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Genomic context

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See ADI1 in Genome Data Viewer
Location:
chromosome: XIII
Exon count:
1
Sequence:
Chromosome: XIII; NC_001145.3 (284102..284641)

Chromosome XIII - NC_001145.3Genomic Context describing neighboring genes Neighboring gene lysophospholipase Neighboring gene uncharacterized protein Neighboring gene Any1p Neighboring gene hexose transporter HXT2

Genomic regions, transcripts, and products

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Genomic Sequence:
NC_001145.3

Go to nucleotide: Graphics FASTA GenBank

Bibliography

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Related articles in PubMed

  1. Membrane-type 1 matrix metalloproteinase cytoplasmic tail binding protein-1 (MTCBP-1) acts as an eukaryotic aci-reductone dioxygenase (ARD) in the methionine salvage pathway. Hirano W, et al. Genes Cells, 2005 Jun. PMID 15938715
  2. Regulation and surveillance of normal and 3'-extended forms of the yeast aci-reductone dioxygenase mRNA by RNase III cleavage and exonucleolytic degradation. Zer C, et al. J Biol Chem, 2005 Aug 12. PMID 15967792
  3. A complete inventory of all enzymes in the eukaryotic methionine salvage pathway. Pirkov I, et al. FEBS J, 2008 Aug. PMID 18625006
  4. Metabolic engineering of Saccharomyces cerevisiae for itaconic acid production. Blazeck J, et al. Appl Microbiol Biotechnol, 2014 Oct. PMID 24997118
  5. Capturing the Asc1p/Receptor for Activated C Kinase 1 (RACK1) Microenvironment at the Head Region of the 40S Ribosome with Quantitative BioID in Yeast. Opitz N, et al. Mol Cell Proteomics, 2017 Dec. PMID 28982715, Free PMC Article

See all (24) citations in PubMed

GeneRIFs: Gene References Into Functions

What's a GeneRIF?
  1. MTCBP-1 acts as a eukaryotic aci-reductone dioxygenase in the methionine salvage pathway.
    Title: Membrane-type 1 matrix metalloproteinase cytoplasmic tail binding protein-1 (MTCBP-1) acts as an eukaryotic aci-reductone dioxygenase (ARD) in the methionine salvage pathway.
Submit: New GeneRIF Correction

Pathways from PubChem

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Interactions

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Products Interactant Other Gene Complex Source Pubs Description

General gene information

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Homology

Gene Ontology Provided by SGD

Function Evidence Code Pubs
enables acireductone dioxygenase (Ni2+-requiring) activity IEA
Inferred from Electronic Annotation
more info
  
enables acireductone dioxygenase (Ni2+-requiring) activity IMP
Inferred from Mutant Phenotype
more info
 PubMed 
enables acireductone dioxygenase [iron(II)-requiring] activity IBA
Inferred from Biological aspect of Ancestor
more info
  
enables acireductone dioxygenase [iron(II)-requiring] activity IEA
Inferred from Electronic Annotation
more info
  
enables dioxygenase activity IEA
Inferred from Electronic Annotation
more info
  
enables iron ion binding IEA
Inferred from Electronic Annotation
more info
  
enables metal ion binding IEA
Inferred from Electronic Annotation
more info
  
enables nickel cation binding IEA
Inferred from Electronic Annotation
more info
  
Process Evidence Code Pubs
involved_in L-methionine salvage from methylthioadenosine IEA
Inferred from Electronic Annotation
more info
  
involved_in L-methionine salvage from methylthioadenosine IGI
Inferred from Genetic Interaction
more info
 PubMed 
involved_in L-methionine salvage from methylthioadenosine IMP
Inferred from Mutant Phenotype
more info
 PubMed 
involved_in L-methionine salvage from methylthioadenosine ISS
Inferred from Sequence or Structural Similarity
more info
 PubMed 
involved_in methionine biosynthetic process IEA
Inferred from Electronic Annotation
more info
  
involved_in methionine metabolic process IBA
Inferred from Biological aspect of Ancestor
more info
  
Component Evidence Code Pubs
located_in cytoplasm HDA PubMed 
located_in cytoplasm IEA
Inferred from Electronic Annotation
more info
  
located_in nucleus HDA PubMed 
located_in nucleus IEA
Inferred from Electronic Annotation
more info
  

General protein information

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Preferred Names
acireductone dioxygenase (Ni2+-requiring)
NP_013722.1
  • Acireductone dioxygenease involved in methionine salvage pathway; transcribed as polycistronic mRNA with YMR010W and regulated post-transcriptionally by RNase III (Rnt1p) cleavage; ADI1 mRNA is induced in heat shock conditions; human ortholog ADI1 can complement yeast adi1 mutant

NCBI Reference Sequences (RefSeq)

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Genome Annotation

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference assembly

Genomic

  1. NC_001145.3 Reference assembly

    Range
    284102..284641
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. NM_001182505.1 → NP_013722.1  TPA: acireductone dioxygenase (Ni2+-requiring) [Saccharomyces cerevisiae S288C]

    See identical proteins and their annotated locations for NP_013722.1

    Status: REVIEWED

    UniProtKB/Swiss-Prot
    D6VZI3, Q03677
    UniProtKB/TrEMBL
    A6ZM70, B3LLR0, B5VPD5, C7GLB0, C8ZEL5, G2WK60, N1NY62
    Conserved Domains (1) summary
    COG1791
    Location:1 → 179
    Adi1; Acireductone dioxygenase (methionine salvage), cupin superfamily [Amino acid transport and metabolism]
Nucleotide Protein
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
Q03677.1

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