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IRC24 sepiapterin reductase family protein IRC24 [ Saccharomyces cerevisiae S288C ]

Gene ID: 854854, updated on 2-Nov-2024

Summary

Official Symbol
IRC24
Official Full Name
sepiapterin reductase family protein IRC24
Primary source
SGD:S000001475
Locus tag
YIR036C
See related
AllianceGenome:SGD:S000001475; FungiDB:YIR036C; VEuPathDB:YIR036C
Gene type
protein coding
RefSeq status
REVIEWED
Organism
Saccharomyces cerevisiae S288C (strain: S288C)
Lineage
Eukaryota; Fungi; Dikarya; Ascomycota; Saccharomycotina; Saccharomycetes; Saccharomycetales; Saccharomycetaceae; Saccharomyces
Summary
Enables benzil reductase [(S)-benzoin-forming] activity and oxidoreductase activity, acting on NAD(P)H, oxygen as acceptor. Located in cytoplasm. Human ortholog(s) of this gene implicated in cortisone reductase deficiency (multiple); hypertension (multiple); and type 2 diabetes mellitus. Orthologous to human HSD11B1 (hydroxysteroid 11-beta dehydrogenase 1). [provided by Alliance of Genome Resources, Nov 2024]
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Genomic context

See IRC24 in Genome Data Viewer
Location:
chromosome: IX
Exon count:
1
Sequence:
Chromosome: IX; NC_001141.2 (422074..422865, complement)

Chromosome IX - NC_001141.2Genomic Context describing neighboring genes Neighboring gene saccharopine dehydrogenase (NAD+, L-lysine-forming) Neighboring gene sepiapterin reductase family protein Neighboring gene peroxiredoxin HYR1 Neighboring gene bifunctional glutathione transferase/peroxidase

Pathways from PubChem

Interactions

Products Interactant Other Gene Complex Source Pubs Description

General protein information

Preferred Names
sepiapterin reductase family protein IRC24
NP_012302.3
  • Benzil oxidoreductase with preference for NADPH; localizes to the cytoplasm; induced by the DNA-damaging agent MMS; null mutant has elevated levels of spontaneous Rad52p foci; sequence similarity with short-chain dehydrogenase/reductases; putative paralog of IRC24

NCBI Reference Sequences (RefSeq)

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Genome Annotation

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference assembly

Genomic

  1. NC_001141.2 Reference assembly

    Range
    422074..422865 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. NM_001179558.3NP_012302.3  TPA: sepiapterin reductase family protein IRC24 [Saccharomyces cerevisiae S288C]

    See identical proteins and their annotated locations for NP_012302.3

    Status: REVIEWED

    UniProtKB/Swiss-Prot
    D6VVW7, P40580, Q54AB5
    UniProtKB/TrEMBL
    A6ZVV6, B3LTH4, C7GLS0, C8ZAT8, G2WFW4, N1P4B2
    Conserved Domains (1) summary
    cd05367
    Location:4255
    SPR-like_SDR_c; sepiapterin reductase (SPR)-like, classical (c) SDRs