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NRE1 sepiapterin reductase family protein [ Saccharomyces cerevisiae S288C ]

Gene ID: 854853, updated on 2-Nov-2024

Summary

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Official Symbol
NRE1
Official Full Name
sepiapterin reductase family protein
Primary source
SGD:S000001474
Locus tag
YIR035C
See related
AllianceGenome:SGD:S000001474; FungiDB:YIR035C; VEuPathDB:YIR035C
Gene type
protein coding
RefSeq status
REVIEWED
Organism
Saccharomyces cerevisiae S288C (strain: S288C)
Lineage
Eukaryota; Fungi; Dikarya; Ascomycota; Saccharomycotina; Saccharomycetes; Saccharomycetales; Saccharomycetaceae; Saccharomyces
Summary
Enables benzil reductase [(S)-benzoin-forming] activity. Located in cytoplasm. Human ortholog(s) of this gene implicated in cortisone reductase deficiency (multiple); hypertension (multiple); and type 2 diabetes mellitus. Orthologous to human HSD11B1 (hydroxysteroid 11-beta dehydrogenase 1). [provided by Alliance of Genome Resources, Nov 2024]
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Genomic context

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See NRE1 in Genome Data Viewer
Location:
chromosome: IX
Exon count:
1
Sequence:
Chromosome: IX; NC_001141.2 (421026..421790, complement)

Chromosome IX - NC_001141.2Genomic Context describing neighboring genes Neighboring gene Mga2p Neighboring gene saccharopine dehydrogenase (NAD+, L-lysine-forming) Neighboring gene sepiapterin reductase family protein IRC24 Neighboring gene peroxiredoxin HYR1

Genomic regions, transcripts, and products

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Genomic Sequence:
NC_001141.2

Go to nucleotide: Graphics FASTA GenBank

Bibliography

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Related articles in PubMed

  1. Saccharomyces cerevisiae NRE1 and IRC24 Encode Paralogous Benzil Oxidoreductases. Garcia B, et al. MicroPubl Biol, 2023. PMID 37602278, Free PMC Article
  2. Heterozygous screen in Saccharomyces cerevisiae identifies dosage-sensitive genes that affect chromosome stability. Strome ED, et al. Genetics, 2008 Mar. PMID 18245329, Free PMC Article
  3. The nucleotide sequence of Saccharomyces cerevisiae chromosome IX. Churcher C, et al. Nature, 1997 May 29. PMID 9169870
  4. Subcellular localization of the yeast proteome. Kumar A, et al. Genes Dev, 2002 Mar 15. PMID 11914276, Free PMC Article
  5. The Hsp90 isoforms from S. cerevisiae differ in structure, function and client range. Girstmair H, et al. Nat Commun, 2019 Aug 9. PMID 31399574, Free PMC Article

See all (25) citations in PubMed

GeneRIFs: Gene References Into Functions

Interactions

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Products Interactant Other Gene Complex Source Pubs Description

General gene information

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Homology

Gene Ontology Provided by SGD

Function Evidence Code Pubs
enables benzil reductase [(S)-benzoin-forming] activity IDA
Inferred from Direct Assay
more info
 PubMed 
enables oxidoreductase activity IEA
Inferred from Electronic Annotation
more info
  
enables oxidoreductase activity, acting on CH-OH group of donors IEA
Inferred from Electronic Annotation
more info
  
enables oxidoreductase activity, acting on NAD(P)H, oxygen as acceptor IBA
Inferred from Biological aspect of Ancestor
more info
  
Process Evidence Code Pubs
involved_in biological_process ND
No biological Data available
more info
  
Component Evidence Code Pubs
located_in cytoplasm HDA PubMed 

General protein information

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Preferred Names
sepiapterin reductase family protein
NP_012301.3
  • Benzil oxidoreductase with preference for NADPH; localizes to the cytoplasm; sequence similarity with short-chain dehydrogenase/reductases; putative paralog of IRC24

NCBI Reference Sequences (RefSeq)

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Genome Annotation

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference assembly

Genomic

  1. NC_001141.2 Reference assembly

    Range
    421026..421790 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. NM_001179557.3 → NP_012301.3  TPA: sepiapterin reductase family protein [Saccharomyces cerevisiae S288C]

    See identical proteins and their annotated locations for NP_012301.3

    Status: REVIEWED

    UniProtKB/Swiss-Prot
    D6VVW6, P40579
    UniProtKB/TrEMBL
    B5VKX2, C7GLS1, G2WFW3, N1P2C7
    Conserved Domains (1) summary
    cd05367
    Location:4 → 246
    SPR-like_SDR_c; sepiapterin reductase (SPR)-like, classical (c) SDRs
Nucleotide Protein
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
P40579.1

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