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CAB2 phosphopantothenate--cysteine ligase CAB2 [ Saccharomyces cerevisiae S288C ]

Gene ID: 854726, updated on 2-Nov-2024

Summary

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Official Symbol
CAB2
Official Full Name
phosphopantothenate--cysteine ligase CAB2
Primary source
SGD:S000001345
Locus tag
YIL083C
See related
AllianceGenome:SGD:S000001345; FungiDB:YIL083C; VEuPathDB:YIL083C
Gene type
protein coding
RefSeq status
REVIEWED
Organism
Saccharomyces cerevisiae S288C (strain: S288C)
Lineage
Eukaryota; Fungi; Dikarya; Ascomycota; Saccharomycotina; Saccharomycetes; Saccharomycetales; Saccharomycetaceae; Saccharomyces
Summary
Enables phosphopantothenate--cysteine ligase activity. Involved in coenzyme A biosynthetic process. Located in cytoplasm and nucleus. Part of CoA-synthesizing protein complex. Used to study cancer and dilated cardiomyopathy. Human ortholog(s) of this gene implicated in dilated cardiomyopathy and dilated cardiomyopathy 2C. Orthologous to human PPCS (phosphopantothenoylcysteine synthetase). [provided by Alliance of Genome Resources, Nov 2024]
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Genomic context

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See CAB2 in Genome Data Viewer
Location:
chromosome: IX
Exon count:
1
Sequence:
Chromosome: IX; NC_001141.2 (203556..204653, complement)

Chromosome IX - NC_001141.2Genomic Context describing neighboring genes Neighboring gene putative mannosyltransferase Neighboring gene Sds3p Neighboring gene gag-pol fusion protein Neighboring gene tRNA-Ile

Genomic regions, transcripts, and products

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Genomic Sequence:
NC_001141.2

Go to nucleotide: Graphics FASTA GenBank

Bibliography

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Related articles in PubMed

  1. Crystallographic Analysis of the Catalytic Mechanism of Phosphopantothenoylcysteine Synthetase from Saccharomyces cerevisiae. Zheng P, et al. J Mol Biol, 2019 Feb 15. PMID 30653991
  2. Mutations in PPCS, Encoding Phosphopantothenoylcysteine Synthetase, Cause Autosomal-Recessive Dilated Cardiomyopathy. Iuso A, et al. Am J Hum Genet, 2018 Jun 7. PMID 29754768, Free PMC Article
  3. Molecular characterization of the heteromeric coenzyme A-synthesizing protein complex (CoA-SPC) in the yeast Saccharomyces cerevisiae. Olzhausen J, et al. FEMS Yeast Res, 2013 Sep. PMID 23789928
  4. Genetic analysis of coenzyme A biosynthesis in the yeast Saccharomyces cerevisiae: identification of a conditional mutation in the pantothenate kinase gene CAB1. Olzhausen J, et al. Curr Genet, 2009 Apr. PMID 19266201
  5. Increased biosynthesis of acetyl-CoA in the yeast Saccharomyces cerevisiae by overexpression of a deregulated pantothenate kinase gene and engineering of the coenzyme A biosynthetic pathway. Olzhausen J, et al. Appl Microbiol Biotechnol, 2021 Oct. PMID 34491400, Free PMC Article

See all (25) citations in PubMed

GeneRIFs: Gene References Into Functions

Pathways from PubChem

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Interactions

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Products Interactant Other Gene Complex Source Pubs Description

General gene information

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Homology

Gene Ontology Provided by SGD

Function Evidence Code Pubs
enables catalytic activity IEA
Inferred from Electronic Annotation
more info
  
enables ligase activity IEA
Inferred from Electronic Annotation
more info
  
enables phosphopantothenate--cysteine ligase activity IBA
Inferred from Biological aspect of Ancestor
more info
  
enables phosphopantothenate--cysteine ligase activity IDA
Inferred from Direct Assay
more info
 PubMed 
enables phosphopantothenate--cysteine ligase activity IEA
Inferred from Electronic Annotation
more info
  
Process Evidence Code Pubs
involved_in coenzyme A biosynthetic process IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in coenzyme A biosynthetic process IEA
Inferred from Electronic Annotation
more info
  
involved_in coenzyme A biosynthetic process IGI
Inferred from Genetic Interaction
more info
 PubMed 
Component Evidence Code Pubs
part_of CoA-synthesizing protein complex IDA
Inferred from Direct Assay
more info
 PubMed 
located_in cytoplasm HDA PubMed 
is_active_in cytoplasm IBA
Inferred from Biological aspect of Ancestor
more info
  
located_in cytoplasm IEA
Inferred from Electronic Annotation
more info
  
located_in nucleus HDA PubMed 
is_active_in nucleus IBA
Inferred from Biological aspect of Ancestor
more info
  
located_in nucleus IEA
Inferred from Electronic Annotation
more info
  

General protein information

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Preferred Names
phosphopantothenate--cysteine ligase CAB2
NP_012183.2
  • Phosphopantothenoylcysteine synthetase (PPCS); catalyzes the second step of coenzyme A biosynthesis from pantothenate; subunit of the CoA-Synthesizing Protein Complex (CoA-SPC) that contains: Cab2p, Cab3p, Cab4p, Cab5p, Sis2p and Vhs3p subunits; null mutant lethality is complemented by human homolog PPCS and by E. coli coaBC, a bifunctional enzyme with PPCS activity

NCBI Reference Sequences (RefSeq)

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Genome Annotation

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference assembly

Genomic

  1. NC_001141.2 Reference assembly

    Range
    203556..204653 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. NM_001179431.2 → NP_012183.2  TPA: phosphopantothenate--cysteine ligase CAB2 [Saccharomyces cerevisiae S288C]

    See identical proteins and their annotated locations for NP_012183.2

    Status: REVIEWED

    UniProtKB/Swiss-Prot
    D6VVK3, P40506
    UniProtKB/TrEMBL
    A6ZVJ3, B3LTT1, B5VKM1, C7GKL1, C8ZAG5, G2WG68, N1P4G8
    Conserved Domains (1) summary
    COG0452
    Location:11 → 365
    CoaBC; Phosphopantothenoylcysteine synthetase/decarboxylase [Coenzyme transport and metabolism]
Nucleotide Protein
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
P40506.2

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