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MOB1 Mob1p [ Saccharomyces cerevisiae S288C ]

Gene ID: 854700, updated on 18-Sep-2024

Summary

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Official Symbol
MOB1
Official Full Name
Mob1p
Primary source
SGD:S000001368
Locus tag
YIL106W
See related
AllianceGenome:SGD:S000001368; FungiDB:YIL106W; VEuPathDB:YIL106W
Gene type
protein coding
RefSeq status
REVIEWED
Organism
Saccharomyces cerevisiae S288C (strain: S288C)
Lineage
Eukaryota; Fungi; Dikarya; Ascomycota; Saccharomycotina; Saccharomycetes; Saccharomycetales; Saccharomycetaceae; Saccharomyces
Summary
Enables kinase regulator activity. Involved in mitotic cytokinesis; protein phosphorylation; and regulation of exit from mitosis. Located in cellular bud neck and mitotic spindle pole body. Part of Sid2-Mob1 complex. Orthologous to several human genes including MOB1B (MOB kinase activator 1B). [provided by Alliance of Genome Resources, Apr 2022]
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Genomic context

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See MOB1 in Genome Data Viewer
Location:
chromosome: IX
Exon count:
2
Sequence:
Chromosome: IX; NC_001141.2 (166415..167444)

Chromosome IX - NC_001141.2Genomic Context describing neighboring genes Neighboring gene putative metalloendopeptidase Neighboring gene 6-phosphofructo-2-kinase Neighboring gene uncharacterized protein Neighboring gene phosphatidylinositol 4,5-bisphosphate-binding protein Neighboring gene Hsp90 cochaperone SHQ1

Genomic regions, transcripts, and products

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Genomic Sequence:
NC_001141.2

Go to nucleotide: Graphics FASTA GenBank

Bibliography

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Related articles in PubMed

  1. Alfalfa Mob1-like proteins are involved in cell proliferation and are localized in the cell division plane during cytokinesis. Citterio S, et al. Exp Cell Res, 2006 Apr 15. PMID 16460730
  2. The identification of transposon-tagged mutations in essential genes that affect cell morphology in Saccharomyces cerevisiae. Chun KT, et al. Genetics, 1996 Jan. PMID 8770583, Free PMC Article
  3. Structural and functional analysis of Saccharomyces cerevisiae Mob1. Mrkobrada S, et al. J Mol Biol, 2006 Sep 22. PMID 16934835
  4. Regulation of the localization of Dbf2 and mob1 during cell division of saccharomyces cerevisiae. Yoshida S, et al. Genes Genet Syst, 2001 Apr. PMID 11434459
  5. Dual Regulation of the mitotic exit network (MEN) by PP2A-Cdc55 phosphatase. Baro B, et al. PLoS Genet, 2013. PMID 24339788, Free PMC Article

See all (67) citations in PubMed

GeneRIFs: Gene References Into Functions

What's a GeneRIF?
  1. Data show that polo-like kinase Cdc5 first phosphorylates Hof1 to allow subsequent phosphorylation by Dbf2-Mob1.
    Title: Phosphorylation-dependent regulation of the F-BAR protein Hof1 during cytokinesis.
  2. Cdk1 phosphorylates the Mob1 protein to inhibit the activity of Dbf2-Mob1 kinase that regulates Cdc14 phosphatase.
    Title: Mutual regulation of cyclin-dependent kinase and the mitotic exit network.
  3. Study shows that a MEN component, protein kinase Dbf2-Mob1, promotes transfer of Cdc14 to the cytoplasm and consequent exit from mitosis by direct phosphorylation of Cdc14 on serine and threonine residues adjacent to a nuclear localization signal.
    Title: Dbf2-Mob1 drives relocalization of protein phosphatase Cdc14 to the cytoplasm during exit from mitosis.
  4. required for establishing passenger protein localization on the mitotic spindle
    Title: The mitotic exit network Mob1p-Dbf2p kinase complex localizes to the nucleus and regulates passenger protein localization.
  5. 2.0 A X-ray crystal structure
    Title: Structural and functional analysis of Saccharomyces cerevisiae Mob1.
Submit: New GeneRIF Correction

Interactions

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Products Interactant Other Gene Complex Source Pubs Description

General gene information

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Homology

Gene Ontology Provided by SGD

Function Evidence Code Pubs
enables kinase regulator activity IDA
Inferred from Direct Assay
more info
 PubMed 
enables metal ion binding IEA
Inferred from Electronic Annotation
more info
  
enables protein kinase activator activity IBA
Inferred from Biological aspect of Ancestor
more info
  
enables zinc ion binding RCA
inferred from Reviewed Computational Analysis
more info
 PubMed 
Process Evidence Code Pubs
involved_in cell division IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in cell division IEA
Inferred from Electronic Annotation
more info
  
involved_in mitotic cytokinesis IMP
Inferred from Mutant Phenotype
more info
 PubMed 
involved_in regulation of exit from mitosis IGI
Inferred from Genetic Interaction
more info
 PubMed 
involved_in regulation of exit from mitosis IMP
Inferred from Mutant Phenotype
more info
 PubMed 
involved_in signal transduction IBA
Inferred from Biological aspect of Ancestor
more info
  
Component Evidence Code Pubs
part_of Sid2-Mob1 complex IDA
Inferred from Direct Assay
more info
 PubMed 
part_of Sid2-Mob1 complex IPI
Inferred from Physical Interaction
more info
 PubMed 
located_in cellular bud neck IDA
Inferred from Direct Assay
more info
 PubMed 
located_in cellular bud neck IEA
Inferred from Electronic Annotation
more info
  
located_in chromosome IEA
Inferred from Electronic Annotation
more info
  
located_in chromosome, centromeric region IEA
Inferred from Electronic Annotation
more info
  
located_in cytoplasm HDA PubMed 
is_active_in cytoplasm IBA
Inferred from Biological aspect of Ancestor
more info
  
located_in cytoplasm IEA
Inferred from Electronic Annotation
more info
  
located_in cytoskeleton IEA
Inferred from Electronic Annotation
more info
  
located_in mitotic spindle pole body IDA
Inferred from Direct Assay
more info
 PubMed 
located_in nuclear periphery HDA PubMed 
is_active_in nucleus IBA
Inferred from Biological aspect of Ancestor
more info
  
located_in nucleus IEA
Inferred from Electronic Annotation
more info
  
located_in spindle pole body IDA
Inferred from Direct Assay
more info
 PubMed 
located_in spindle pole body IEA
Inferred from Electronic Annotation
more info
  

General protein information

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Preferred Names
Mob1p
NP_012160.2
  • Component of the mitotic exit network; associates with and is required for the activation and Cdc15p-dependent phosphorylation of the Dbf2p kinase; required for cytokinesis and cell separation; component of the CCR4 transcriptional complex; relocalizes from cytoplasm to the nuclear periphery upon DNA replication stress

NCBI Reference Sequences (RefSeq)

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Genome Annotation

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference assembly

Genomic

  1. NC_001141.2 Reference assembly

    Range
    166415..167444
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. NM_001179454.1 → NP_012160.2  TPA: Mob1p [Saccharomyces cerevisiae S288C]

    See identical proteins and their annotated locations for NP_012160.2

    Status: REVIEWED

    UniProtKB/Swiss-Prot
    D6VVI1, P40484
    UniProtKB/TrEMBL
    A6ZVH1, B3LTV3, C8ZAD9, G2WG46, N1P0W7
    Conserved Domains (1) summary
    pfam03637
    Location:134 → 304
    Mob1_phocein; Mob1/phocein family
Nucleotide Protein
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
P40484.2

Gene LinkOut

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