HIS5 histidinol-phosphate transaminase [Saccharomyces cerevisiae S288C] - Gene

Summary

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Official Symbol: HIS5
Official Full Name: histidinol-phosphate transaminase
Primary source: SGD:S000001378
Locus tag: YIL116W
See related: AllianceGenome:SGD:S000001378; FungiDB:YIL116W; VEuPathDB:YIL116W
Gene type: protein coding
RefSeq status: REVIEWED
Organism: Saccharomyces cerevisiae S288C (strain: S288C)
Lineage: Eukaryota; Fungi; Dikarya; Ascomycota; Saccharomycotina; Saccharomycetes; Saccharomycetales; Saccharomycetaceae; Saccharomyces
Summary: Enables histidinol-phosphate transaminase activity. Involved in L-histidine biosynthetic process. Located in cytoplasm. [provided by Alliance of Genome Resources, Nov 2024]
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Genomic context

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See HIS5 in Genome Data Viewer

Location:: chromosome: IX

Exon count:: 1

Sequence:: Chromosome: IX; NC_001141.2 (142928..144085)

Chromosome IX - NC_001141.2 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Go to reference sequence details

Genomic Sequence:: NC_001141.2

Go to nucleotide: Graphics FASTA GenBank

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

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Pathways from PubChem

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Interactions

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Products	Interactant	Other Gene	Complex	Source	Pubs	Description

General gene information

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Homology

Orthologs from OrthoDB

Gene Ontology Provided by SGD

Function	Evidence Code	Pubs
enables histidinol-phosphate transaminase activity	IEA Inferred from Electronic Annotation more info
enables histidinol-phosphate transaminase activity	IMP Inferred from Mutant Phenotype more info	PubMed
enables pyridoxal phosphate binding	IEA Inferred from Electronic Annotation more info
enables transaminase activity	IEA Inferred from Electronic Annotation more info

Process	Evidence Code	Pubs
involved_in L-histidine biosynthetic process	IEA Inferred from Electronic Annotation more info
involved_in L-histidine biosynthetic process	IMP Inferred from Mutant Phenotype more info	PubMed

Component	Evidence Code	Pubs
located_in cytoplasm	HDA more info	PubMed

General protein information

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Preferred Names: histidinol-phosphate transaminase

NP_012150.1

EC 2.6.1.9

Histidinol-phosphate aminotransferase; catalyzes the seventh step in histidine biosynthesis; responsive to general control of amino acid biosynthesis; mutations cause histidine auxotrophy and sensitivity to Cu, Co, and Ni salts

NCBI Reference Sequences (RefSeq)

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Genome Annotation

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference assembly

Genomic

NC_001141.2 Reference assembly

Range

142928..144085

Download

GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

NM_001179464.1 → NP_012150.1 TPA: histidinol-phosphate transaminase [Saccharomyces cerevisiae S288C]

See identical proteins and their annotated locations for NP_012150.1

Status: REVIEWED

UniProtKB/Swiss-Prot

D6VVH1, P07172

UniProtKB/TrEMBL

A6ZVG1, B3LTW3, B5VKJ3, C8ZAC8, G2WG35, N1P1X8

Conserved Domains (1) summary

TIGR01141
Location:10 → 377

hisC; histidinol-phosphate aminotransferase