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RPI1 Rpi1p [ Saccharomyces cerevisiae S288C ]

Gene ID: 854687, updated on 18-Sep-2024

Summary

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Official Symbol
RPI1
Official Full Name
Rpi1p
Primary source
SGD:S000001381
Locus tag
YIL119C
See related
AllianceGenome:SGD:S000001381; FungiDB:YIL119C; VEuPathDB:YIL119C
Gene type
protein coding
RefSeq status
REVIEWED
Organism
Saccharomyces cerevisiae S288C (strain: S288C)
Lineage
Eukaryota; Fungi; Dikarya; Ascomycota; Saccharomycotina; Saccharomycetes; Saccharomycetales; Saccharomycetaceae; Saccharomyces
Summary
Enables GTPase regulator activity. Involved in Ras protein signal transduction; fungal-type cell wall biogenesis; and positive regulation of transcription by RNA polymerase II. Located in nucleus. [provided by Alliance of Genome Resources, Apr 2022]
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Genomic context

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See RPI1 in Genome Data Viewer
Location:
chromosome: IX
Exon count:
1
Sequence:
Chromosome: IX; NC_001141.2 (136654..137877, complement)

Chromosome IX - NC_001141.2Genomic Context describing neighboring genes Neighboring gene cation transporter Neighboring gene multidrug transporter Neighboring gene Rho family GTPase RHO3 Neighboring gene pheromone-regulated protein PRM5

Genomic regions, transcripts, and products

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Genomic Sequence:
NC_001141.2

Go to nucleotide: Graphics FASTA GenBank

Bibliography

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Related articles in PubMed

  1. Genetic variation in Saccharomyces cerevisiae: circuit diversification in a signal transduction network. Chin BL, et al. Genetics, 2012 Dec. PMID 23051644, Free PMC Article
  2. Critical role of RPI1 in the stress tolerance of yeast during ethanolic fermentation. Puria R, et al. FEMS Yeast Res, 2009 Dec. PMID 19678848
  3. Adaptability of the Saccharomyces cerevisiae yeasts to wine fermentation conditions relies on their strong ability to consume nitrogen. Brice C, et al. PLoS One, 2018. PMID 29432462, Free PMC Article
  4. Overexpression of RPI1, a novel inhibitor of the yeast Ras-cyclic AMP pathway, down-regulates normal but not mutationally activated ras function. Kim JH, et al. Mol Cell Biol, 1991 Aug. PMID 1649384, Free PMC Article
  5. Yeast Rpi1 is a putative transcriptional regulator that contributes to preparation for stationary phase. Sobering AK, et al. Eukaryot Cell, 2002 Feb. PMID 12455971, Free PMC Article

See all (28) citations in PubMed

GeneRIFs: Gene References Into Functions

Interactions

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Products Interactant Other Gene Complex Source Pubs Description

General gene information

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Homology

Gene Ontology Provided by SGD

Function Evidence Code Pubs
enables DNA binding IEA
Inferred from Electronic Annotation
more info
  
enables GTPase regulator activity IMP
Inferred from Mutant Phenotype
more info
 PubMed 
Process Evidence Code Pubs
involved_in Ras protein signal transduction IMP
Inferred from Mutant Phenotype
more info
 PubMed 
involved_in fungal-type cell wall biogenesis IGI
Inferred from Genetic Interaction
more info
 PubMed 
involved_in fungal-type cell wall biogenesis IMP
Inferred from Mutant Phenotype
more info
 PubMed 
involved_in positive regulation of transcription by RNA polymerase II IMP
Inferred from Mutant Phenotype
more info
 PubMed 
Component Evidence Code Pubs
located_in nucleus IDA
Inferred from Direct Assay
more info
 PubMed 
located_in nucleus IEA
Inferred from Electronic Annotation
more info
  

General protein information

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Preferred Names
Rpi1p
NP_012147.3
  • Transcription factor, allelic differences between S288C and Sigma1278b; mediates fermentation stress tolerance by modulating cell wall integrity; overexpression suppresses heat shock sensitivity of wild-type RAS2 overexpression and also suppresses cell lysis defect of mpk1 mutation; allele from S288c can confer fMAPK pathway independent transcription of FLO11; S288C and Sigma1278b alleles differ in number of tandem repeats within ORF

NCBI Reference Sequences (RefSeq)

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Genome Annotation

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference assembly

Genomic

  1. NC_001141.2 Reference assembly

    Range
    136654..137877 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. NM_001179467.3 → NP_012147.3  TPA: Rpi1p [Saccharomyces cerevisiae S288C]

    See identical proteins and their annotated locations for NP_012147.3

    Status: REVIEWED

    UniProtKB/Swiss-Prot
    D6VVG8, E9P8U9, P23250
    UniProtKB/TrEMBL
    C7GWJ1, N1P0V6
    Conserved Domains (1) summary
    pfam13837
    Location:95 → 157
    Myb_DNA-bind_4; Myb/SANT-like DNA-binding domain
Nucleotide Protein
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
P23250.2

Gene LinkOut

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