SSL2 TFIIH/NER complex ATPase/helicase subunit SSL2 [Saccharomyces cerevisiae S288C] - Gene

Summary

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Official Symbol: SSL2
Official Full Name: TFIIH/NER complex ATPase/helicase subunit SSL2
Primary source: SGD:S000001405
Locus tag: YIL143C
See related: AllianceGenome:SGD:S000001405; FungiDB:YIL143C; VEuPathDB:YIL143C
Gene type: protein coding
RefSeq status: REVIEWED
Organism: Saccharomyces cerevisiae S288C (strain: S288C)
Lineage: Eukaryota; Fungi; Dikarya; Ascomycota; Saccharomycotina; Saccharomycetes; Saccharomycetales; Saccharomycetaceae; Saccharomyces
Also known as: LOM3; RAD25
Summary: Enables DNA helicase activity and DNA translocase activity. Involved in several processes, including poly(A)+ mRNA export from nucleus; regulation of mitotic recombination; and transcription by RNA polymerase II. Located in cytosol and nucleus. Part of RNA polymerase II transcription regulator complex; nucleotide-excision repair factor 3 complex; and transcription preinitiation complex. Used to study Cockayne syndrome and xeroderma pigmentosum. Human ortholog(s) of this gene implicated in Cockayne syndrome; lung non-small cell carcinoma; trichothiodystrophy (multiple); and xeroderma pigmentosum (multiple). Orthologous to human ERCC3 (ERCC excision repair 3, TFIIH core complex helicase subunit). [provided by Alliance of Genome Resources, Nov 2024]
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Genomic context

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See SSL2 in Genome Data Viewer

Location:: chromosome: IX

Exon count:: 1

Sequence:: Chromosome: IX; NC_001141.2 (80510..83041, complement)

Chromosome IX - NC_001141.2 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Go to reference sequence details

Genomic Sequence:: NC_001141.2

Go to nucleotide: Graphics FASTA GenBank

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Ssl2/TFIIH function in transcription start site scanning by RNA polymerase II in Saccharomyces cerevisiae.
Title: Ssl2/TFIIH function in transcription start site scanning by RNA polymerase II in Saccharomyces cerevisiae.
Rad25 turnover requires the ubiquitin-conjugating enzyme Ubc4 and the ubiquitin ligase Ufd4.
Title: Rad25 protein is targeted for degradation by the Ubc4-Ufd4 pathway.

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Pathways from PubChem

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Interactions

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Products	Interactant	Other Gene	Complex	Source	Pubs	Description

General gene information

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Homology

Orthologs from OrthoDB

Gene Ontology Provided by SGD

Function	Evidence Code	Pubs
enables 3'-5' DNA helicase activity	IBA Inferred from Biological aspect of Ancestor more info
enables ATP binding	IEA Inferred from Electronic Annotation more info
enables ATP hydrolysis activity	IEA Inferred from Electronic Annotation more info
enables DNA binding	IEA Inferred from Electronic Annotation more info
enables DNA helicase activity	IDA Inferred from Direct Assay more info	PubMed
enables DNA helicase activity	IEA Inferred from Electronic Annotation more info
enables DNA translocase activity	IMP Inferred from Mutant Phenotype more info	PubMed
enables helicase activity	IEA Inferred from Electronic Annotation more info
enables hydrolase activity	IEA Inferred from Electronic Annotation more info
enables isomerase activity	IEA Inferred from Electronic Annotation more info

Process	Evidence Code	Pubs
involved_in DNA duplex unwinding	IDA Inferred from Direct Assay more info	PubMed
involved_in DNA repair	IEA Inferred from Electronic Annotation more info
involved_in RNA polymerase II promoter clearance	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in nucleotide-excision repair	IDA Inferred from Direct Assay more info	PubMed
involved_in nucleotide-excision repair	IEA Inferred from Electronic Annotation more info
involved_in poly(A)+ mRNA export from nucleus	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in regulation of mitotic recombination	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in transcription by RNA polymerase II	IDA Inferred from Direct Assay more info	PubMed
involved_in transcription initiation at RNA polymerase II promoter	IBA Inferred from Biological aspect of Ancestor more info
involved_in transcription initiation at RNA polymerase II promoter	IEA Inferred from Electronic Annotation more info
involved_in transcription initiation at RNA polymerase II promoter	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in transcription open complex formation at RNA polymerase II promoter	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in transcriptional start site selection at RNA polymerase II promoter	IMP Inferred from Mutant Phenotype more info	PubMed

Component	Evidence Code	Pubs
located_in cytosol	IDA Inferred from Direct Assay more info	PubMed
part_of nucleotide-excision repair factor 3 complex	IBA Inferred from Biological aspect of Ancestor more info
part_of nucleotide-excision repair factor 3 complex	IDA Inferred from Direct Assay more info	PubMed
located_in nucleus	IDA Inferred from Direct Assay more info	PubMed
located_in nucleus	IEA Inferred from Electronic Annotation more info
part_of transcription factor TFIIH core complex	IDA Inferred from Direct Assay more info	PubMed
part_of transcription factor TFIIH holo complex	IBA Inferred from Biological aspect of Ancestor more info
part_of transcription factor TFIIH holo complex	IDA Inferred from Direct Assay more info	PubMed
part_of transcription preinitiation complex	IBA Inferred from Biological aspect of Ancestor more info
part_of transcription preinitiation complex	IDA Inferred from Direct Assay more info	PubMed

General protein information

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Preferred Names: TFIIH/NER complex ATPase/helicase subunit SSL2

NP_012123.1

EC 3.6.4.12

Component of RNA polymerase transcription factor TFIIH holoenzyme; acts as dsDNA-dependent translocase in context of TFIIH, unwinds DNA strands during initiation and promotes transcription start site (TSS) scanning; has DNA-dependent ATPase/helicase activity; interacts functionally with TFIIB, has roles in TSS selection and gene looping to juxtapose initiation and termination regions; involved in DNA repair; relocalizes to cytosol under hypoxia; homolog of human ERCC3

NCBI Reference Sequences (RefSeq)

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Genome Annotation

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference assembly

Genomic

NC_001141.2 Reference assembly

Range

80510..83041 complement

Download

GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

NM_001179491.1 → NP_012123.1 TPA: TFIIH/NER complex ATPase/helicase subunit SSL2 [Saccharomyces cerevisiae S288C]

See identical proteins and their annotated locations for NP_012123.1

Status: REVIEWED

UniProtKB/Swiss-Prot

D6VVE4, Q00578

UniProtKB/TrEMBL

A6ZVD3, B3LTZ0, C7GUR0, G2WG09, N1P0T0

Conserved Domains (1) summary

TIGR00603
Location:117 → 835

rad25; DNA repair helicase rad25