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SYC1 cleavage polyadenylation factor subunit SYC1 [ Saccharomyces cerevisiae S288C ]

Gene ID: 854351, updated on 2-Nov-2024

Summary

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Official Symbol
SYC1
Official Full Name
cleavage polyadenylation factor subunit SYC1
Primary source
SGD:S000005705
Locus tag
YOR179C
See related
AllianceGenome:SGD:S000005705; FungiDB:YOR179C; VEuPathDB:YOR179C
Gene type
protein coding
RefSeq status
REVIEWED
Organism
Saccharomyces cerevisiae S288C (strain: S288C)
Lineage
Eukaryota; Fungi; Dikarya; Ascomycota; Saccharomycotina; Saccharomycetes; Saccharomycetales; Saccharomycetaceae; Saccharomyces
Summary
Predicted to enable RNA binding activity. Involved in negative regulation of mRNA 3'-end processing. Located in nucleus. Part of mRNA cleavage and polyadenylation specificity factor complex. [provided by Alliance of Genome Resources, Nov 2024]
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Genomic context

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See SYC1 in Genome Data Viewer
Location:
chromosome: XV
Exon count:
1
Sequence:
Chromosome: XV; NC_001147.6 (671845..672411, complement)

Chromosome XV - NC_001147.6Genomic Context describing neighboring genes Neighboring gene Mpc54p Neighboring gene protein phosphatase regulator GAC1 Neighboring gene putative dodecenoyl-CoA isomerase DCI1 Neighboring gene actin-binding protein LAS17

Genomic regions, transcripts, and products

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Genomic Sequence:
NC_001147.6

Go to nucleotide: Graphics FASTA GenBank

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?
  1. Syc1 plays a more important role in snoRNA production.Syc1 is the defining subunit of a distinct APT complex, and is not part of CPF complex.
    Title: The APT complex is involved in non-coding RNA transcription and is distinct from CPF.
  2. Syc1, by mimicking the essential Brr5 C-terminus, serves as a negative regulator of mRNA 3'-end formation.
    Title: The role of the Brr5/Ysh1 C-terminal domain and its homolog Syc1 in mRNA 3'-end processing in Saccharomyces cerevisiae.
Submit: New GeneRIF Correction

Interactions

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Products Interactant Other Gene Complex Source Pubs Description

General gene information

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Homology

Gene Ontology Provided by SGD

Function Evidence Code Pubs
enables RNA binding IC
Inferred by Curator
more info
 PubMed 
Process Evidence Code Pubs
involved_in mRNA processing IEA
Inferred from Electronic Annotation
more info
  
involved_in negative regulation of mRNA 3'-end processing IMP
Inferred from Mutant Phenotype
more info
 PubMed 
Component Evidence Code Pubs
part_of mRNA cleavage and polyadenylation specificity factor complex IDA
Inferred from Direct Assay
more info
 PubMed 
located_in nucleus HDA PubMed 
located_in nucleus IEA
Inferred from Electronic Annotation
more info
  

General protein information

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Preferred Names
cleavage polyadenylation factor subunit SYC1
NP_014822.1
  • Subunit of the APT subcomplex of cleavage and polyadenylation factor; may have a role in 3' end formation of both polyadenylated and non-polyadenylated RNAs; SYC1 has a paralog, YSH1, that arose from the whole genome duplication

NCBI Reference Sequences (RefSeq)

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Genome Annotation

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference assembly

Genomic

  1. NC_001147.6 Reference assembly

    Range
    671845..672411 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. NM_001183598.1 → NP_014822.1  TPA: cleavage polyadenylation factor subunit SYC1 [Saccharomyces cerevisiae S288C]

    See identical proteins and their annotated locations for NP_014822.1

    Status: REVIEWED

    UniProtKB/Swiss-Prot
    D6W2N5, Q08553
    UniProtKB/TrEMBL
    B5VS64, C7GLR4, N1P3B5
    Conserved Domains (1) summary
    cl13209
    Location:28 → 186
    CPSF73-100_C; Pre-mRNA 3'-end-processing endonuclease polyadenylation factor C-term
Nucleotide Protein
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
Q08553.1

Gene LinkOut

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