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GCY1 glycerol 2-dehydrogenase (NADP(+)) GCY1 [ Saccharomyces cerevisiae S288C ]

Gene ID: 854287, updated on 2-Nov-2024

Summary

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Official Symbol
GCY1
Official Full Name
glycerol 2-dehydrogenase (NADP(+)) GCY1
Primary source
SGD:S000005646
Locus tag
YOR120W
See related
AllianceGenome:SGD:S000005646; FungiDB:YOR120W; VEuPathDB:YOR120W
Gene type
protein coding
RefSeq status
REVIEWED
Organism
Saccharomyces cerevisiae S288C (strain: S288C)
Lineage
Eukaryota; Fungi; Dikarya; Ascomycota; Saccharomycotina; Saccharomycetes; Saccharomycetales; Saccharomycetaceae; Saccharomyces
Summary
Enables aldose reductase (NADPH) activity; glycerol dehydrogenase [NAD(P)+] activity; and mRNA binding activity. Involved in cellular response to oxidative stress; glycerol to glycerone phosphate metabolic process; and pentose catabolic process. Located in cytoplasm and nucleus. Human ortholog(s) of this gene implicated in several diseases, including 46,XY sex reversal 8; congenital bile acid synthesis defect 2; diabetic neuropathy; leukemia (multiple); and type 2 diabetes mellitus. Orthologous to several human genes including AKR1B1 (aldo-keto reductase family 1 member B) and AKR1B10 (aldo-keto reductase family 1 member B10). [provided by Alliance of Genome Resources, Nov 2024]
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Genomic context

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See GCY1 in Genome Data Viewer
Location:
chromosome: XV
Exon count:
1
Sequence:
Chromosome: XV; NC_001147.6 (551114..552052)

Chromosome XV - NC_001147.6Genomic Context describing neighboring genes Neighboring gene Rtc5p Neighboring gene protein kinase RIO1 Neighboring gene profilin Neighboring gene Leo1p

Genomic regions, transcripts, and products

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Genomic Sequence:
NC_001147.6

Go to nucleotide: Graphics FASTA GenBank

Bibliography

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Related articles in PubMed

  1. Transcriptional control by galactose of a yeast gene encoding a protein homologous to mammalian aldo/keto reductases. Magdolen V, et al. Gene, 1990 May 31. PMID 2199324
  2. A nuclear yeast gene (GCY) encodes a polypeptide with high homology to a vertebrate eye lens protein. Oechsner U, et al. FEBS Lett, 1988 Sep 26. PMID 2901985
  3. The general regulatory factor Reb1p controls basal, but not Gal4p-mediated, transcription of the GCY1 gene in yeast. Angermayr M, et al. Mol Gen Genet, 1997 Nov. PMID 9435793
  4. Crystallization and aldo-keto reductase activity of Gcy1p from Saccharomyces cerevisiae. Hur E, et al. Acta Crystallogr D Biol Crystallogr, 2000 Jun. PMID 10818358
  5. The crystal structure of the GCY1 protein from S. cerevisiae suggests a divergent aldo-keto reductase catalytic mechanism. Hur E, et al. Chem Biol Interact, 2001 Jan 30. PMID 11306072

See all (56) citations in PubMed

GeneRIFs: Gene References Into Functions

Pathways from PubChem

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Interactions

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Products Interactant Other Gene Complex Source Pubs Description

General gene information

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Homology

Gene Ontology Provided by SGD

Function Evidence Code Pubs
enables aldo-keto reductase (NADPH) activity IDA
Inferred from Direct Assay
more info
 PubMed 
enables aldose reductase (NADPH) activity IBA
Inferred from Biological aspect of Ancestor
more info
  
enables aldose reductase (NADPH) activity IDA
Inferred from Direct Assay
more info
 PubMed 
enables aldose reductase (NADPH) activity IEA
Inferred from Electronic Annotation
more info
  
enables glycerol 2-dehydrogenase (NADP+) activity IEA
Inferred from Electronic Annotation
more info
  
enables glycerol dehydrogenase [NAD(P)+] activity IMP
Inferred from Mutant Phenotype
more info
 PubMed 
enables mRNA binding IDA
Inferred from Direct Assay
more info
 PubMed 
enables oxidoreductase activity IDA
Inferred from Direct Assay
more info
 PubMed 
enables oxidoreductase activity IEA
Inferred from Electronic Annotation
more info
  
Process Evidence Code Pubs
involved_in D-xylose catabolic process IDA
Inferred from Direct Assay
more info
 PubMed 
involved_in D-xylose catabolic process IEA
Inferred from Electronic Annotation
more info
  
involved_in arabinose catabolic process IDA
Inferred from Direct Assay
more info
 PubMed 
involved_in arabinose catabolic process IEA
Inferred from Electronic Annotation
more info
  
involved_in cellular response to oxidative stress IEA
Inferred from Electronic Annotation
more info
  
involved_in cellular response to oxidative stress IGI
Inferred from Genetic Interaction
more info
 PubMed 
involved_in glycerol metabolic process IEA
Inferred from Electronic Annotation
more info
  
involved_in glycerol to glycerone phosphate metabolic process IGI
Inferred from Genetic Interaction
more info
 PubMed 
involved_in glycerol to glycerone phosphate metabolic process IMP
Inferred from Mutant Phenotype
more info
 PubMed 
Component Evidence Code Pubs
located_in cytoplasm HDA PubMed 
located_in cytoplasm IEA
Inferred from Electronic Annotation
more info
  
is_active_in cytosol IBA
Inferred from Biological aspect of Ancestor
more info
  
located_in nucleus HDA PubMed 

General protein information

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Preferred Names
glycerol 2-dehydrogenase (NADP(+)) GCY1
NP_014763.1
  • Glycerol dehydrogenase; involved in an alternative pathway for glycerol catabolism used under microaerobic conditions; also has mRNA binding activity; member of the aldo-keto reductase (AKR) family; human homolog AKR1B1 can complement yeast null mutant; protein abundance increases in response to DNA replication stress; GCY1 has a paralog, YPR1, that arose from the whole genome duplication

NCBI Reference Sequences (RefSeq)

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Genome Annotation

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference assembly

Genomic

  1. NC_001147.6 Reference assembly

    Range
    551114..552052
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. NM_001183539.1 → NP_014763.1  TPA: glycerol 2-dehydrogenase (NADP(+)) GCY1 [Saccharomyces cerevisiae S288C]

    See identical proteins and their annotated locations for NP_014763.1

    Status: REVIEWED

    UniProtKB/Swiss-Prot
    D6W2H9, P14065
    UniProtKB/TrEMBL
    A6ZNW8, B3LJG3, B5VS12, N1NYF5
    Conserved Domains (1) summary
    cd19117
    Location:7 → 296
    AKR_AKR3A1-2; AKR3A family of aldo-keto reductase (AKR)
Nucleotide Protein
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
P14065.1

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