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YVC1 Yvc1p [ Saccharomyces cerevisiae S288C ]

Gene ID: 854255, updated on 2-Nov-2024

Summary

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Official Symbol
YVC1
Official Full Name
Yvc1p
Primary source
SGD:S000005613
Locus tag
YOR087W
See related
AllianceGenome:SGD:S000005613; FungiDB:YOR087W; VEuPathDB:YOR087W
Gene type
protein coding
RefSeq status
REVIEWED
Organism
Saccharomyces cerevisiae S288C (strain: S288C)
Lineage
Eukaryota; Fungi; Dikarya; Ascomycota; Saccharomycotina; Saccharomycetes; Saccharomycetales; Saccharomycetaceae; Saccharomyces
Also known as
YOR088W
Summary
Enables monoatomic ion channel activity. Involved in calcium ion transmembrane import into cytosol and intracellular monoatomic cation homeostasis. Located in fungal-type vacuole membrane and vacuole-mitochondrion membrane contact site. Human ortholog(s) of this gene implicated in several diseases, including Charcot-Marie-Tooth disease axonal type 2C; keratosis (multiple); migraine (multiple); motor neuron disease (multiple); and osteochondrodysplasia (multiple). Orthologous to several human genes including TRPV1 (transient receptor potential cation channel subfamily V member 1); TRPV2 (transient receptor potential cation channel subfamily V member 2); and TRPV3 (transient receptor potential cation channel subfamily V member 3). [provided by Alliance of Genome Resources, Nov 2024]
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Genomic context

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See YVC1 in Genome Data Viewer
Location:
chromosome: XV
Exon count:
1
Sequence:
Chromosome: XV; NC_001147.6 (487707..489734)

Chromosome XV - NC_001147.6Genomic Context describing neighboring genes Neighboring gene tricalbin Neighboring gene tRNA-Asn Neighboring gene Rab family GTPase VPS21 Neighboring gene type 2C protein phosphatase PTC5

Genomic regions, transcripts, and products

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Genomic Sequence:
NC_001147.6

Go to nucleotide: Graphics FASTA GenBank

Bibliography

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Related articles in PubMed

  1. Cation-selective channels in the vacuolar membrane of Saccharomyces: dependence on calcium, redox state, and voltage. Bertl A, et al. Proc Natl Acad Sci U S A, 1990 Oct. PMID 1700419, Free PMC Article
  2. A TRP homolog in Saccharomyces cerevisiae forms an intracellular Ca(2+)-permeable channel in the yeast vacuolar membrane. Palmer CP, et al. Proc Natl Acad Sci U S A, 2001 Jul 3. PMID 11427713, Free PMC Article
  3. Structure of the ancient TRPY1 channel from Saccharomyces cerevisiae reveals mechanisms of modulation by lipids and calcium. Ahmed T, et al. Structure, 2022 Jan 6. PMID 34453887, Free PMC Article
  4. Heterologously expressed fungal transient receptor potential channels retain mechanosensitivity in vitro and osmotic response in vivo. Zhou XL, et al. Eur Biophys J, 2005 Jul. PMID 15711808
  5. Yeast screens show aromatic residues at the end of the sixth helix anchor transient receptor potential channel gate. Zhou X, et al. Proc Natl Acad Sci U S A, 2007 Sep 25. PMID 17878311, Free PMC Article

See all (51) citations in PubMed

GeneRIFs: Gene References Into Functions

What's a GeneRIF?
  1. Activity of the yeast vacuolar TRP channel TRPY1 is inhibited by Ca(2+)-calmodulin binding.
    Title: Activity of the yeast vacuolar TRP channel TRPY1 is inhibited by Ca(2+)-calmodulin binding.
  2. Data show that Ca(2+) on the lumen side inhibited channel activity of vacuolar cation channel TRPY1 protein (Yvc1 protein).
    Title: In vitro and in vivo characterization of modulation of the vacuolar cation channel TRPY1 from Saccharomyces cerevisiae.
  3. Yvc1p has nine cysteine residues, of which eight are located in the cytoplasmic regions and one on the transmembrane domain. We show that three of these cysteines, Cys-17, Cys-79, and Cys-191, are specifically glutathionylated.
    Title: Glutathione depletion activates the yeast vacuolar transient receptor potential channel, Yvc1p, by reversible glutathionylation of specific cysteines.
Submit: New GeneRIF Correction

Pathways from PubChem

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Interactions

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Products Interactant Other Gene Complex Source Pubs Description

General gene information

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Homology

Gene Ontology Provided by SGD

Function Evidence Code Pubs
enables calcium channel activity IBA
Inferred from Biological aspect of Ancestor
more info
  
enables calcium channel activity IDA
Inferred from Direct Assay
more info
 PubMed 
enables calcium channel activity IEA
Inferred from Electronic Annotation
more info
  
enables calcium-activated cation channel activity IDA
Inferred from Direct Assay
more info
 PubMed 
enables potassium channel activity IDA
Inferred from Direct Assay
more info
 PubMed 
enables sodium channel activity IDA
Inferred from Direct Assay
more info
 PubMed 
enables voltage-gated monoatomic ion channel activity IDA
Inferred from Direct Assay
more info
 PubMed 
Process Evidence Code Pubs
involved_in calcium ion import across plasma membrane IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in calcium ion transmembrane import into cytosol IMP
Inferred from Mutant Phenotype
more info
 PubMed 
involved_in calcium ion transmembrane transport IEA
Inferred from Electronic Annotation
more info
  
involved_in intracellular monoatomic cation homeostasis IDA
Inferred from Direct Assay
more info
 PubMed 
involved_in intracellular monoatomic cation homeostasis IMP
Inferred from Mutant Phenotype
more info
 PubMed 
involved_in potassium ion transmembrane transport IEA
Inferred from Electronic Annotation
more info
  
involved_in sodium ion transmembrane transport IEA
Inferred from Electronic Annotation
more info
  
Component Evidence Code Pubs
located_in fungal-type vacuole IDA
Inferred from Direct Assay
more info
 PubMed 
located_in fungal-type vacuole membrane HDA PubMed 
located_in fungal-type vacuole membrane IDA
Inferred from Direct Assay
more info
 PubMed 
located_in membrane IEA
Inferred from Electronic Annotation
more info
  
is_active_in plasma membrane IBA
Inferred from Biological aspect of Ancestor
more info
  
located_in vacuolar membrane IEA
Inferred from Electronic Annotation
more info
  
located_in vacuole IEA
Inferred from Electronic Annotation
more info
  
located_in vacuole-mitochondrion membrane contact site IDA
Inferred from Direct Assay
more info
 PubMed 

General protein information

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Preferred Names
Yvc1p
NP_014730.2
  • Vacuolar cation channel; mediates release of Ca(2+) from the vacuole in response to hyperosmotic shock

NCBI Reference Sequences (RefSeq)

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Genome Annotation

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference assembly

Genomic

  1. NC_001147.6 Reference assembly

    Range
    487707..489734
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. NM_001183506.1 → NP_014730.2  TPA: Yvc1p [Saccharomyces cerevisiae S288C]

    See identical proteins and their annotated locations for NP_014730.2

    Status: REVIEWED

    UniProtKB/Swiss-Prot
    D6W2E9, Q08500, Q12324, Q7LGN3
    UniProtKB/TrEMBL
    A6ZNT8, B3LJD4, B5VRY3, C7GMP6, N1NVS1
    Conserved Domains (1) summary
    pfam00520
    Location:235 → 470
    Ion_trans; Ion transport protein
Nucleotide Protein
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
Q12324.2

Gene LinkOut

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